Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging

Okugawa, Gaku; Takase, Katsunori; Nobuhara, Kenji; Yoshida, Terufumi; Minami, Toyohiko; Tamagaki, Chiharu; Magnotta, Vincent A.; Andreasen, Nancy C.; Kinoshita, Toshihiko

doi:10.1007/s00406-003-0444-3

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…The data sets were then segmented into grey matter, white matter and cerebral spinal fluid using a multispectral data analysis method based on automated training class selection [15] . The reproducibility and reliability of the segmentation procedure were previously confirmed [16,17] . The intracranial volume was measured by the BRAINS program.…”

Section: Mri Scansmentioning

confidence: 96%

Cerebellar Posterior Superior Vermis and Cognitive Cluster Scores in Drug-Naive Patients with First-Episode Schizophrenia

Okugawa¹,

Nobuhara²,

Takase³

et al. 2007

Neuropsychobiology

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Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present study, MRI scans were acquired from 14 drug-naive patients with first-episode schizophrenia and 16 healthy subjects, and used to measure the volumes of their cerebellar subregions. Positive symptom, negative symptom and cognitive cluster scores were attained using the Positive and Negative Syndrome Scale. Patients with first-episode schizophrenia had reduced volumes of the anterior vermis and posterior superior vermis compared with healthy subjects. We confirmed that there was a volume reduction of the cerebellar vermis in drug-naive patients with first-episode schizophrenia. Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia.

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Section: Mri Scansmentioning

confidence: 96%

Cerebellar Posterior Superior Vermis and Cognitive Cluster Scores in Drug-Naive Patients with First-Episode Schizophrenia

Okugawa¹,

Nobuhara²,

Takase³

et al. 2007

Neuropsychobiology

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“…Detailed information on the segmentation procedure and an evaluation of validity have been given by Harris et al (24). Reproducibility and reliability of the segmentation procedure have also been ascertained previously by our research group (25,26).…”

Section: Tissue Segmentationmentioning

confidence: 99%

Altered White Matter/Gray Matter Proportions in the Striatum of Patients With Schizophrenia: A Volumetric MRI Study

Tamagaki¹,

Sedvall²,

Jönsson³

et al. 2005

AJP

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“…Reproducibility and reliability of the tissue class volume measures resulting from the segmentation procedure have been ascertained previously [Harris et al, 1999;Agartz et al, 2001;Okugawa et al, 2003b]. Briefly, two independent operators blinded to subject diagnosis and identity performed the automatic segmentation as well as the manual tracing.…”

Section: Reliability Of Volume Measurementsmentioning

confidence: 99%

BDNF gene variants and brain morphology in schizophrenia

Agartz

Sedvall

Terenius

et al. 2006

American J of Med Genetics Pt B

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The objective was to investigate putative associations between brain-derived neurotrophic factor gene (BDNF) polymorphisms and brain morphology in patients with schizophrenia and healthy control subjects. Four BDNF polymorphisms were genotyped and analyzed versus 39 brain volume measures in 96 patients with schizophrenia or schizoaffective disorder and 104 healthy subjects. In all subjects, quantitative data on segmented gray, white, and cerebrospinal fluid (CSF) tissue class volumes of total brain and major cerebral lobes including ventricular CSF were obtained using magnetic resonance imaging (MRI). In a randomly selected subset of this population (n = 101-122), MR volumes from cerebellar tonsil, hemispheres, and vermis subregions, striatal structures, hippocampus, and corpus callosum were also measured. The BDNF 11757 G/C polymorphism was highly significantly associated with frontal gray matter volume variation in patients alone and in patients and control subjects combined. In patients only, the 270 C/T polymorphism was associated with total caudate volume. Significant associations were demonstrated between the BDNF 11757 G/C and Val66Met polymorphisms and a global haplotype estimate of four BDNF polymorphisms and the posterior superior cerebellar vermis volume in the controls as well as in the combined group, but not in the patients. The 11757 G/C polymorphism was associated with cerebellar hemisphere white and gray matter volumes in the combined group. The BDNF -633 T/A polymorphism was associated with gray matter of the putamen in the controls. Trends for associations between several polymorphisms/haplotype estimates and MRI volumes were found. BDNF gene variation may influence brain morphology. The effects may be different in patients with schizophrenia and healthy subjects.

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Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging

Cited by 17 publications

References 10 publications

Cerebellar Posterior Superior Vermis and Cognitive Cluster Scores in Drug-Naive Patients with First-Episode Schizophrenia

Cerebellar Posterior Superior Vermis and Cognitive Cluster Scores in Drug-Naive Patients with First-Episode Schizophrenia

Altered White Matter/Gray Matter Proportions in the Striatum of Patients With Schizophrenia: A Volumetric MRI Study

BDNF gene variants and brain morphology in schizophrenia

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