Inter-centre reliability in embryo grading across several IVF clinics is limited: implications for embryo selection

Morphometric assessment of blastocysts: relationship with the ongoing pregnancy rate

“…The strengths of morphometric assessment of blastocysts are noninvasiveness and cost-effectiveness, as it is performed using digital images taken in routine static embryo observations. Furthermore, the interobserver agreements of the 3 morphometric variables obtained in the current study were surprisingly high compared with the conventional morphological grades in previous studies ( 12 , 19 ). Therefore, the morphometric approach may improve the predictive ability of blastocyst morphology for pregnancy success.…”

Correlation between an annotation-free embryo scoring system based on deep learning and live birth/neonatal outcomes after single vitrified-warmed blastocyst transfer: a single-centre, large-cohort retrospective study

“…A previous study suggested that miscarriage could be predicted based on the trophectoderm grade and embryo morphokinetic [ 10 , 39 ]. However, evaluation of trophectoderm and direct cleavage is subjective and affected by both inter- and intra-observer variations [ 40 ]. A potentially more consistent and generalizable estimation of TM can thus be obtained by using iDAScore.…”

“…Potential side effects can occur if traits are indirectly correlated with high likelihood of implantation. For example, embryo developmental speed, morphokinetic parameters, and blastocyst grade [ 21 , 40 , 46 , 47 ] have been reported to correlate with both sex ratio and implantation likelihood. In a study on iDAScore, it was shown that scores correlate with both time to blastocyst and blastocyst grades [ 30 ].…”

Biophysical models of early mammalian embryogenesis

“…For example, in the case of IVF, modeling could be useful in determining which physical processes are often implicated in blastocyst failure, allowing laboratories to improve their embryo profile grading system. Since most clinics employ static morphological assessments of embryos, modeling could also investigate the effect of relative cell numbers in the ICM and trophectoderm or the relative cell diameters on blastocyst failure rates ( Cimadomo et al., 2022 ).…”