Inter-chromosomal variation in aberration frequencies in human lymphocytes exposed to charged particles of LET between 0.5 and 55 keV/μm

Abstract

In lymphocytes of donors studied in this work chromosome 2 appears to be consistently less sensitive to protons and heavy ions than chromosomes 8 and 14. Complex aberrations appear to be a potential marker of radiation quality.

Individual variations in the micronucleus assay for biological dosimetry after high dose exposure

“…One method to circumvent the problem of proliferation inhibition is the induction of premature chromosome condensation (PCC) [2,6,7] and this technique has been successfully applied to detect the doses absorbed during the Tokaimura radiation accident [8]. However, PCC is not widely established, perhaps due to the high skill required for the analysis of aberrations.…”

Monte Carlo Modeling of DNA Lesions and Chromosomal Aberrations Induced by Mixed Beams of Alpha Particles and X-Rays

“…Staaf et al [12] presented aberration frequencies scored in chromosomes 2, 8, and 14. For comparing the observed frequencies with those generated by MC simulations, wholegenome frequencies of aberrations were calculated as described by Lucas et al [23], assuming that the fraction of the male human whole-genome DNA represented by chromosomes 2, 8, and 14 is 0.0803, 0.0488, and 0.0338, respectively [24]. The envelopes of additivity [25] were constructed based on dose-response curves for CA induced by X-rays and alpha radiation.…”