Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

Hasler, Roland; Preti, Maria Giulia; Meskaldji, Djalel Eddine; Prados, Julien; Adouan, Wafae; Rodriguez, Cristelle; Toma, Simona; Hiller, N.; Ismaili, T.; Hofmeister, Jérémy; Sinanaj, Indrit; Baud, Patrick; Haller, Sven; Giannakopoulos, Pantéleimon; Schwartz, Sophie; Perroud, Nader; Ville, Dimitri Van De

doi:10.1016/j.pscychresns.2017.09.004

Cited by 18 publications

(16 citation statements)

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“…While asymmetries most likely involve the frontoparietal, attention, and default mode networks, no study so far has precisely mapped the exact underlying connectivity asymmetries in full. Studies so far have either focused on asymmetries of connections within the left hemisphere or the right hemisphere (Tzourio-Mazoyer et al 2015 ), address specific regions of interest (Fox et al 2006 ; Xiao et al 2016 ; Hasler et al 2017 ), or have obtained condensed asymmetry metrics by quantifying the mean amount of asymmetric connections per voxel (Joliot et al 2016 ). While these approaches certainly have their merits, they do not provide a full and simultaneously assessment of any connectivity asymmetries between and within hemispheres.…”

Section: Introductionmentioning

confidence: 99%

Knowing left from right: asymmetric functional connectivity during resting state

et al. 2018

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The functional organization of left and right hemispheres is different, and hemispheric asymmetries are thought to underlie variations in brain function across individuals. In this study, we assess how differences between hemispheres are reflected in Asymmetric Functional Connectivity (AFC), which provides a full description of how the brain’s connectivity structure during resting state differs from that of the same brain mirrored over the longitudinal fissure. In addition, we assess how AFC varies across subjects. Data were provided by the Human Connectome Project, including 423 resting state and combined language task fMRI data sets, and the pattern of AFC was established for all subjects. While we could quantify the symmetry of brain connectivity at 95%, significant asymmetries were observed, consisting foremost of: (1) higher correlations between language areas in the left hemisphere than between their right hemisphere homologues. (2) Higher correlations between language homologue areas in the right hemisphere and left default mode network, than between language areas in the left hemisphere and the default mode network in the right hemisphere. The extent to which subjects exhibited this pattern correlated with language lateralization and handedness. Further exploration in intersubject variation in AFC revealed several additional patterns, one involving entire hemispheres, and another correlations with limbic areas. These results show that language is an important, but not only determinant of AFC. The additional patterns of AFC require further research to be linked to specific asymmetric neuronal states or events.Electronic supplementary materialThe online version of this article (10.1007/s00429-017-1604-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Knowing left from right: asymmetric functional connectivity during resting state

et al. 2018

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“…In ADHD patients, a study demonstrated that higher connectivity between the right hippocampus, the parietal lobe (supramarginal and angular gyrus), and the frontal lobe (superior and middle frontal gyrus) in carriers of the AG or GG variant of rs8079626 within the BAIAP2 gene (brain-specific angiogenesis inhibitor) was related to higher anger expression-out (or an unmanageable tendency to manifest anger externally) in ADHD patients [41].…”

Section: Resultsmentioning

confidence: 99%

The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review

Romero‐Martínez

González

Lila

et al. 2019

Behavioral Sciences

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Introduction: There is growing scientific interest in understanding the biological mechanisms affecting and/or underlying violent behaviors in order to develop effective treatment and prevention programs. In recent years, neuroscientific research has tried to demonstrate whether the intrinsic activity within the brain at rest in the absence of any external stimulation (resting-state functional connectivity; RSFC) could be employed as a reliable marker for several cognitive abilities and personality traits that are important in behavior regulation, particularly, proneness to violence. Aims: This review aims to highlight the association between the RSFC among specific brain structures and the predisposition to experiencing anger and/or responding to stressful and distressing situations with anger in several populations. Methods: The scientific literature was reviewed following the PRISMA quality criteria for reviews, using the following digital databases: PubMed, PsycINFO, Psicodoc, and Dialnet. Results: The identification of 181 abstracts and retrieval of 34 full texts led to the inclusion of 17 papers. The results described in our study offer a better understanding of the brain networks that might explain the tendency to experience anger. The majority of the studies highlighted that diminished RSFC between the prefrontal cortex and the amygdala might make people prone to reactive violence, but that it is also necessary to contemplate additional cortical (i.e., insula, gyrus [angular, supramarginal, temporal, fusiform, superior, and middle frontal], anterior and posterior cingulated cortex) and subcortical brain structures (i.e., hippocampus, cerebellum, ventral striatum, and nucleus centralis superior) in order to explain a phenomenon as complex as violence. Moreover, we also described the neural pathways that might underlie proactive violence and feelings of revenge, highlighting the RSFC between the OFC, ventral striatal, angular gyrus, mid-occipital cortex, and cerebellum. Conclusions. The results from this synthesis and critical analysis of RSFC findings in several populations offer guidelines for future research and for developing a more accurate model of proneness to violence, in order to create effective treatment and prevention programs.

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“…Additionally, we also observed DNA methylation alterations of BAIAP2 and OXTR in sPTB cord blood, which were related to neurodevelopmental disorders. To specify, BAIAP2 encodes brain-specific angiogenesis inhibitor - binding protein that is involved in neurodevelopmental/ neurite outgrowth network [73], and its genotype and expression were associated with autism spectrum disorders (ASD) [74] and attention-deficit/hyperactivity disorder (ADHD) [73, 75, 76]. The methylation of the oxytocin receptor ( OXTR ) was also associated with ASD [25, 77].…”

Section: Discussionmentioning

confidence: 99%

Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood

et al. 2019

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BackgroundThe etiology and mechanism of spontaneous preterm birth (sPTB) are still unclear. Accumulating evidence has documented that various environmental exposure scenarios may cause maternal and fetal epigenetic changes, which initiates the focus on whether epigenetics can contribute to the occurrence of sPTB. Therefore, we conducted the current study to examine and compare the DNA methylation changes associated with sPTB in placenta and cord blood.MethodsThis hospital-based case-control study was carried out at three Women and Children’s hospitals in South China, where 32 spontaneous preterm births and 16 term births were recruited. Genome-wide DNA methylation profiles of the placenta and cord blood from these subjects were measured using the Illumina HumanMethylation EPIC BeadChip, and sPTB-associated differential methylated CpG sites were identified using limma regression model, after controlling for major maternal and infant confounders. Further Gene Ontology analysis was performed with PANTHER in order to assess different functional enrichment of the sPTB-associated genes in placenta and cord blood.ResultsAfter controlling for potential confounding factors, one differentially methylated position (DMP) in placenta and 31 DMPs in cord blood were found significantly associated with sPTB (Bonferroni corrected p < 0.05). The sPTB-associated CpG sites in placenta were mapped to genes that showed higher enrichment on biological processes including biological regulation, multicellular organismal process, and especially response to stimulus, while those in cord blood were mapped to genes that had higher enrichment on biological processes concerning cellular process, localization, and particularly metabolic process.ConclusionFindings of this study indicated that DNA methylation alteration in both placenta and cord blood are associated with sPTB, yet the DNA methylation modification patterns may appear differently in placenta and cord blood.Electronic supplementary materialThe online version of this article (10.1186/s12920-018-0466-3) contains supplementary material, which is available to authorized users.

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Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

Cited by 18 publications

References 82 publications

Knowing left from right: asymmetric functional connectivity during resting state

Knowing left from right: asymmetric functional connectivity during resting state

The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review

Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood

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