2017
DOI: 10.1007/s40279-017-0680-8
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Inter-Individual Responses of Maximal Oxygen Uptake to Exercise Training: A Critical Review

Abstract: It has recently been reported how to quantify inter-individual differences in the response to an exercise intervention using the standard deviation of the change scores, as well as how to appraise these differences for clinical relevance. In a parallel-group randomised controlled trial, the key trigger for further investigation into inter-individual responses is when the standard deviation of change in the intervention sample is substantially larger than the same standard deviation derived from a suitable comp… Show more

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Cited by 77 publications
(108 citation statements)
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References 65 publications
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“…We just provided Mr Mazzolari with a reference to a recent meta‐analysis of parallel‐group controlled studies suggesting the absence of inter‐individual differences in V̇O2 max trainability to a given dose of training (Williamson et al . ), thereby complementing our findings. The submission was rejected by the responsible editor.…”
Section: Physiology Over Tangential Wordinesssupporting
confidence: 89%
See 1 more Smart Citation
“…We just provided Mr Mazzolari with a reference to a recent meta‐analysis of parallel‐group controlled studies suggesting the absence of inter‐individual differences in V̇O2 max trainability to a given dose of training (Williamson et al . ), thereby complementing our findings. The submission was rejected by the responsible editor.…”
Section: Physiology Over Tangential Wordinesssupporting
confidence: 89%
“…This was composed of identical extracts from the preceding letter, adding the reference provided (Williamson et al . ) along with a paradoxical swing of the author's opinion of our article. The Journal of Physiology also rejected this version.…”
Section: Physiology Over Tangential Wordinessmentioning
confidence: 69%
“…It has been suggested that the response to exercise may be influenced by a multitude of individual characteristics, including sex , genetics , age, and baseline status of the measured outcome . Clinically relevant inter‐individual response variation should be quantified and judged properly before the clinical relevance of these effect modifiers of response are appraised, relative to a robust minimal clinically important difference (MCID). Crucially, this quantification requires an appropriate control/comparator group, preferably within a randomized trial design.…”
Section: Introductionmentioning
confidence: 99%
“…Regrettably, substantial treatment response heterogeneity has been claimed from observations solely on the intervention group . When the comparator sample is absent or ignored, the interpretation of response heterogeneity is prone to all the philosophical issues highlighted by Stephen Senn, particularly the problem of the ‘counterfactual’ .…”
Section: Introductionmentioning
confidence: 99%
“…; Atkinson & Batterham ; Williamson et al . ) highlight the importance of a relevant comparator arm when examining inter‐individual differences in response to training (SD R ), emphasising that the results of parallel studies are meaningful only when the standard deviation (SD) of the change score(s) in the intervention group(s) (SD I ) is substantially larger than the SD of the change score in the control group (SD C ), according to the equation: SD R = √(SD I 2 – SD C 2 ). The absence of a non‐exercising comparator arm in the study of Montero and Lundby represents a strong limitation in this sense since it impedes the separation of the true inter‐individual variability in CRF response to ET from the technical error of measurement and random intra‐individual biological variation.…”
mentioning
confidence: 99%