Change of direction (COD) ability is essential for sport performance in high level team sports such as basketball, however, the influence of asymmetries on COD ability is relatively unknown. Forty-three junior and senior level elite basketball players performed isometric hip and trunk strength testing, passive hip and trunk range of motion testing, and unilateral horizontal and vertical jumps, as well as the T-test to measure COD performance. Mean asymmetry values ranged from 0.76% for functional leg length up to 40.35% for rate of torque development during hip flexion. A six-variable regression model explained 48% (R2 = 0.48; p < 0.001) of variation in COD performance. The model included left hip internal/external rotation strength ratio, and inter-limb asymmetries in hip abduction rate of torque development, hip flexion range of motion, functional leg length, single leg triple jump distance, and peak torque during trunk lateral flexion. Results suggest that the magnitude of asymmetries is dependent of task and parameter, and using universal asymmetry thresholds, such as <10 %, is not optimal. The regression model showed the relationship between asymmetries and COD performance. None of tests were sufficient to explain a complex variable like COD performance.