Inter-observer reproducibility of semi-automatic tumor diameter measurement and volumetric analysis in patients with lung cancer

Dinkel, Julien; Khalilzadeh, Omid; Hintze, C.; Fabel, M.; Puderbach, Michael; Eichinger, Monika; Schlemmer, H. P.; Thorn, Matthias; Thomas, Michael; Kauczor, Hans‐Ulrich; Biederer, Jürgen

doi:10.1016/j.lungcan.2013.07.006

Cited by 44 publications

(32 citation statements)

References 27 publications

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“…These advantages permit more reliable and accurate classification of the therapeutic response and directly influence treatment decisions. These studies are limited in that they mostly focused on the relatively easy task of lung nodule [17,22,23] or lymph node segmentation in CT examinations [12,13].…”

Section: Discussionmentioning

confidence: 99%

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

Höink

Schülke

Koch

et al. 2017

Fortschr Röntgenstr

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ZUSAMMENFASSUNGZiel Vergleich von Messgenauigkeit und Interobserver-Variabilität in der computertomografischen Beurteilung von hepatozellulären Karzinomen (HCC) und Lebermetastasen vor und nach transarteriellen selektiven Therapien. Material und MethodenRetrospektive Studie an 72 Patienten mit malignen Leberläsionen (42 Metastasen, 30 HCC) vor und nach Therapie mit SIRT (n = 42) oder TACE (n = 29).Etablierte (LAD, SAD, WHO) und Vitalitäts-assoziierte Größenparameter (mRECIST, mLAD, mSAD, EASL) wurden manuell und semiautomatisch von zwei Auswertern bestimmt. Die relative Interobserverdifferenz (RID) und der Intraclass Korrelationskoeffizient (ICC) wurden berechnet.Ergebnisse Die mediane RID der Vitalitäts-assoziierten Parameter war für die semiautomatischen niedriger als für die manuellen Messverfahren, im Einzelnen: für mLAD 3,4 % gegenüber 12,5 %; für mSAD 5,7 % gegenüber 12,7 %; für This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. ABSTR AC TPurpose To compare measurement precision and interobserver variability in the evaluation of hepatocellular carcinoma (HCC) and liver metastases in MSCT before and after transarterial local ablative therapies. Materials and MethodsRetrospective study of 72 patients with malignant liver lesions (42 metastases; 30 HCCs) before and after therapy (43 SIRT procedures; 29 TACE procedures). Established (LAD; SAD; WHO) and vitality-based parameters (mRECIST; mLAD; mSAD; EASL) were assessed manually and semi-automatically by two readers. The relative interobserver difference (RID) and intraclass correlation coefficient (ICC) were calculated.Results The median RID for vitality-based parameters was lower from semi-automatic than from manual measurement of mLAD (manual 12.5 %; semi-automatic 3.4 %), mSAD (manual 12.7 %; semi-automatic 5.7 %) and EASL (manual 10.4 %; semi-automatic 1.8 %). The difference in established parameters was not statistically noticeable (p > 0.05). The ICCs of LAD (manual 0.984; semi-automatic 0.982), SAD (manual 0.975; semi-automatic 0.958) and WHO (manual 0.984; semi-automatic 0.978) are high, both in manual and semi-automatic measurements. The ICCs of manual measurements of mLAD (0.897), mSAD (0.844) and EASL (0.875) are lower. This decrease cannot be found in semi-automatic measurements of mLAD (0.997), mSAD (0.992) and EASL (0.998).Conclusion Vitality-based tumor measurements of HCC and metastases after transarterial local therapies should be performed semi-automatically due to greater measurement precision, thus increasing the reproducibility and in turn the reliability of therapeutic decisions.

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Section: Discussionmentioning

confidence: 99%

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

Höink

Schülke

Koch

et al. 2017

Fortschr Röntgenstr

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“…The reliability of semi-automatic volumetric analysis is subject to ongoing research. Studies comparing the interobserver and/or intraobserver variability between semi-automatic and manual volume measurements have shown comparable results, namely, a superiority of semi-automatic measurements, depending on entity and used modality (14)(15)(16)(17). Also, this method depends on detection of lesions following Gd-EOB-DTPA enhancement.…”

Section: Discussionmentioning

confidence: 99%

Semi-automatic 3D-volumetry of liver metastases from neuroendocrine tumors to improve combination therapy with 177Lu-DOTATOC and 90Y-DOTATOC

Cieciera

Kratochwil

Moltz

et al. 2016

Diagn Interv Radiol

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PURPOSE Patients with neuroendocrine tumors (NET) often present with disseminated liver metastases and can be treated with a number of different nuclides or nuclide combinations in peptide receptor radionuclide therapy (PRRT) depending on tumor load and lesion diameter. For quantification of disseminated liver lesions, semi-automatic lesion detection is helpful to determine tumor burden and tumor diameter in a time efficient manner. Here, we aimed to evaluate semi-automated measurement of total metastatic burden for therapy stratification. METHODS Nineteen patients with liver metastasized NET underwent contrast-enhanced 1.5 T MRI using gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid. Liver metastases (n=1537) were segmented using Fraunhofer MEVIS Software for three-dimensional (3D) segmentation. All lesions were stratified according to longest 3D diameter >20 mm or <= 20 mm and relative contribution to tumor load was used for therapy stratification. RESULTS Mean count of lesions <= 20 mm was 67.5 and mean count of lesions > 20 mm was 13.4. However, mean contribution to total tumor volume of lesions <= 20 mm was 24%, while contribution of lesions > 20 mm was 76%. CONCLUSION Semi-automatic lesion analysis provides useful information about lesion distribution in predominantly liver metastasized NET patients prior to PRRT. As conventional manual lesion measurements are laborious, our study shows this new approach is more efficient and less operator-dependent and may prove to be useful in the decision making process selecting the best combination PRRT in each patient

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“…Variation among physicians is well documented (e.g., van Herk 2004; Louie et al 2010;Fotina et al 2012;Dinkel et al 2013;Whitfield et al 2013). However, there is a lack of consensus on which measures to use for judging the variability (Fotina et al 2012).…”

Section: Inter-observer Variation Among Outcomesmentioning

confidence: 99%

The influence of automation on tumor contouring

et al. 2017

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Fully or semi-automatic contouring tools are increasingly being used in the tumor contouring task for radiotherapy. While the fully automatic contouring tools have not reached sufficient efficiency, the semi-automatic contouring tools balance more effectively between the human interaction and automation. This study evaluates the influences of a semi-automation contouring tool, called between-slice interpolation, on the resulting contours and the contouring process. The tumor contouring study was conducted on three patient cases with five physicians in a naturalistic setting. The contouring task consisted of initiating the 2D contour manually or with the interpolation tool and correcting that initial contour. The similarity of the resulting contours was pairwise measured within the manual or the interpolated category. Interactions with the software were recorded, and variations in the contouring workflows steps were compared. Results indicated that using the between-slice interpolation tool for creating the initial contour, instead of initiating it manually, influenced both the contouring process and outcomes. First, it was identified that contours initiated by the interpolation tool showed an increased similarity among themselves compared to the manually initiated contours. At the same time, influences to the resulting contours were below clinical relevance, and toward the desired direction-improved consistency of contours. Second, when interpolation was used, in two cases out of three, the average contouring time also decreased significantly. Therefore, the use of such an automation tool can be encouraged.

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Inter-observer reproducibility of semi-automatic tumor diameter measurement and volumetric analysis in patients with lung cancer

Cited by 44 publications

References 27 publications

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

Semi-automatic 3D-volumetry of liver metastases from neuroendocrine tumors to improve combination therapy with 177Lu-DOTATOC and 90Y-DOTATOC

The influence of automation on tumor contouring

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