Inter-observer variation and diagnostic efficacy of apparent diffusion coefficient (ADC) measurements obtained by diffusion-weighted imaging (DWI) in small renal masses

Abstract

ADC measurements of SRM at 3 T show a high reproducibility and differentiate papillary from non-papillary carcinoma subtypes. However, measurement variability may limit the application of fixed ADC thresholds for lesion diagnosis.

Diagnostic Accuracy of MRI for Detection of Papillary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

“…The flow and timing of patients through the study was also unclear in nine studies [4, 16–19, 21, 22, 25, 26]; these studies either did not mention the mean time between MRI and tissue sampling or did not specify the time interval between MRI and tissue sampling in the inclusion criteria [4, 16–19, 21, 22, 25, 26]. Concerns of the applicability of the index test arose as unclear in four studies [16, 18, 19, 27], two of which involved ADC measurements on 3-T scanners instead of 1.5-T scanners [18, 27] and one in which the scans were obtained on a mix of 3- and 1.5-T scanners with application of a numeric threshold for test positivity [16]. In the fourth study [19], the enhancement of the renal mass was measured on whichever sequence the interpreter determined maximum enhancement was shown; there was no standardized timed sequence to measure enhancement to enable direct comparison and reproducibility [19].…”

Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis

“…DWI is an imaging technique used to analyze diseases at cellular and molecular levels, and is the only non-invasive inspection method capable of in vivo determination of water molecular diffusion motion in the tissues (6). Application of DWI in cerebral schistosomiasis has not been reported.…”

“…Diffusion-weighted imaging (DWI) has received broad attention since its introduction into clinical application in the early 1990s, primarily in the detection of acute ischemic stroke, being widely used in clinical practice in recent years. As a functional imaging method, DWI is sensitive to the microscopic motion of the water molecules and can provide quantitative analysis through ADC value measurement (6). Since cerebral schistosomiasis is an inflammatory lesion, it is reasonable to assume that the movement of water molecules through it is different with respect to their movement in brain tumors.…”

With 3 Types of Respiratory Acquisition: 3.0 T Respiratory Triggered Acquisition Can Obtain Higher Quality DWI Images of the Upper Abdomen

“…Without increasing the total scanning time [ 5 ], routine MRI sequences have enrolled DWI [ 6 ], and currently, DWI is commonly adopted for quantitative and qualitative analyses of organs in the upper abdomen [ 7 ]. DWI techniques include respiratory-triggered, breath-holding, and free-breathing acquisitions [ 4 ]. The breath-holding technique sacrifices the signal-to-noise ratio (SNR), so the scanning time is relatively short.…”

“…Diffusion-weighted imaging (DWI), which is widely adopted in clinical practice, is a diagnostic technology that uses water molecule diffusion motion characteristics for imaging [1][2][3][4]. Without increasing the total scanning time [5], routine MRI sequences have enrolled DWI [6], and currently, DWI is commonly adopted for quantitative and qualitative analyses of organs in the upper abdomen [7].…”