Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance

Gaur, Poonam; Singh, Avadhesh Kumar; Shukla, Nootan Kumar; Das, Srinibas

doi:10.1016/j.humimm.2014.01.011

Cited by 44 publications

(39 citation statements)

References 39 publications

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“…18,21 Similarly, a shift toward Th2-related cytokines, with an increase of IL-4, IL-10 and TGFb, and a subsequent decrease of the most important Th1 mediator, INFg, is often observed in HNSCC. 9,[22][23][24][25][26][27][28] The increase of IL-10, known as one of the strongest immune suppressive factors, is correlated with tumor staging, nodal involvement and to a worst prognostic factor. 25 Moreover, IL-10 levels markedly decrease after chemotherapeutic treatment, thus suggesting that cancer cells are the main source of this cytokine in HNSCC.…”

Section: T-helper Cells and Hnscc Development T-helper (Th) Lymphocytmentioning

confidence: 99%

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Maggioni

Garavello

2017

OncoImmunology

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Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells. HNSCC patients often have defective immune functions, thus allowing cancer immune escape and cancer spreading. Particularly important in driving immune escape during HNSCC progression are T-helper and T-regulatory cells. New insights into their mechanisms of action might support the development of effective and long-lasting immunotherapy.

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Section: T-helper Cells and Hnscc Development T-helper (Th) Lymphocytmentioning

confidence: 99%

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Maggioni

Garavello

2017

OncoImmunology

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“…These cytokines, in combination with other molecules (such as IL-21, IL-23, RORγt and Fox-P3) are involved in a complex, tightly-regulated network that controls immune function. Disruption of this network may lead to immune dysfunction, uncontrolled cell growth, chronic inflammation and ultimately carcino genesis (16). In the present study, the delicate balance between the three Figure 2.…”

Section: Discussionmentioning

confidence: 64%

“…TGFβ1, a member of the TGFβ family that is predominantly secreted by Tregs, is another multi-functional cytokine. It promotes tumor progression by inducing mesenchymal transition, tumor escape by antagonizing IL-2 functions and inducing immune suppression (16,17), tumor invasion and metastasis (18).…”

Section: Introductionmentioning

confidence: 99%

Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma

Wang

et al. 2016

Oncology Letters

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Abstract. T-helper (Th) 0 cell differentiation into Th1 or Th2 cells is dependent on a number of transcription factors that act at specific time points to regulate gene expression. Th17 cells, a subset of interleukin (IL)-17-producing T cells distinct from Th1 or Th2 cells, are considered to exhibit a critical function in inflammation and autoimmune diseases, as well as cancer development. In the present study, the expression of Th1-, Th2-and Th17-associated cytokines in laryngeal cancer and pericarcinoma tissues obtained from 57 laryngeal carcinoma patients was investigated. The association between Th1, Th2 and Th17 infiltration and tumor development was also evaluated. Reverse transcription-polymerase chain reaction and western blotting results revealed that the mRNA and protein expression of Th2 cytokines was lower, while the expression of Th1 and Th17 cytokines was higher in tumor tissues than in pericarcinoma tissues. Furthermore, the early stage cancer patients exhibited a higher level of interferon-γ, IL-2 and IL-17 mRNA expression than those at advanced stages. Cancer tissues exhibited higher Th17 cytokine expression than pericarcinoma tissues. By contrast, Th1 cytokine expression was increased in pericarcinoma tissues compared with cancer tissues. These results indicate that high expression of Th1-and Th17-associated cytokines in laryngeal carcinoma may contribute to suppression of cancer development and a relatively good prognosis.

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“…So, fresh cells are necessary for detection of Th subsets in tumor microenviroments. Most of previous studies have focused on the expression and clinical significance of helper T cells in peripheral blood of cancer patients, but the study of Th subsets in human tumor tissue infiltration is little using flow cytometry [8–11]. Tosolini et al reported that tissue infiltrating Th subsets in patient with colon cancer, but the method used is immunohistochemistry (IHC), which might be not accurate enough to quantify the levels of Th subsets compared with flow cytometry.…”

Section: Introductionmentioning

confidence: 99%

Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC

et al. 2017

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CD4+Th subsets play an important role in tumor progression but their expression characteristics and clinical significance in human tumor microenvironment remains unclear. In this study, we aim to analyze the expression and clinical significance of tissue-infiltrating Th1, Th2 and Th17 in lung cancer by flow cytometry. We found that the frequency of CD3+CD4+IFN-γ+Th1 in tumor nest was significantly lower than that in tumor boundary, adjacent normal lung tissue or corresponding lymph node tissue; the frequency of CD3+CD4+IL-4+Th2 in tumor nest was significantly higher than that in tumor boundary, adjacent normal lung tissue or corresponding lymph node tissue; the frequency of CD3+CD4+IL-17+Th17 in tumor nest was significantly lower than that in tumor boundary, but not adjacent normal tissue or corresponding lymph node tissue. Survival analysis of 2-years survival after surgery showed that Th1high group was significantly lower compared with Th1low group; Th2high and Th17low is a good prognosis index compared with the Th2low and Th17high groups respectively, but this difference failed to significance. In addition, we also found that PD-1 expression showed a high level on lung tumor tissues and adjacent non- tumor tissue infiltrating T cells, and no significant difference was found between the two groups. However PD-L1 on CD45+CD14+mononcytes/macrophages in tumor tissue show a significantly higher level compared with that in adjacent nontumor tissues. In vitro stimulation experiments showed that IFN-γ could significantly increase PD-L1 expression on monocyte. In conclusion, we for the first time found Th1high is a poor indicator for prognosis of lung cancer.

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Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance

Cited by 44 publications

References 39 publications

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma

Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC

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