Inter-species investigation of the mechano-regulation of bone healing: Comparison of secondary bone healing in sheep and rat

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

“…Similar observations have been reported before in a bone chamber study where no significant difference was found between the bone ingrowth rate in rats and goats [26]. In a recent study, a contradictory result has been reported where it has been proposed that bone healing process is probably different between rat and sheep [27]. While this species dependency of the parameters is not by itself a limitation of the proposed model, generalization of identified parameters between species should be verified by experimental data.…”

Is the callus shape an optimal response to a mechanobiological stimulus?

“…Specifically, the computational results reported in the literature are usually smaller in length and width compared to in vivo sizes. In fact, in silico dimensions are at best, 30% [36] and 19% [1] smaller than in vivo lengths and widths, respectively. In our study, the calluses are wider and lengthier and are thus more similar to in vivo dimensions.…”

A new intramedullary sustained dynamic compression nail for the treatment of long bone fractures: a biomechanical study

“…In previous experimental studies 300 N, 500 N, 700 N and one and half times of body weight compressive loading have been suggested for bone healing. [26][27][28][29][30] In our study, it was possible to use 400 N compressive loading. In addition to this, 750 N loading was used to represent body weight and total load was equal to approximately one and half times of body weight.…”