Inter-subject, inter-ocular and inter-session repeatability of the photopic negative response of the electroretinogram recorded using DTL and skin electrodes

Mortlock, Katharine Eirlys; Binns, Alison; Aldebasi, Yousef H.; North, R. V.

doi:10.1007/s10633-010-9239-9

Cited by 55 publications

(93 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reduction found in peak-to-peak amplitudes recorded with skin electrodes in our study is consistent with previous reports of reductions of 75% and 80% (9) , 43%-73% (10) , 50%-70% (11) , 50% (12) , 23%-62% (13) , and 42%-57% (14) . Our data showed reductions between 46% and 62% on the peak-to-peak amplitudes.…”

Section: Discussionsupporting

confidence: 93%

Full-field electroretinogram recorded with skin electrodes in normal adults

Salomão¹,

Pereira²,

Berezovsky³

2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

Approved by the following research ethics committee: Universidade Federal de São Paulo UNIFESP (#0174/04). ABSTRACT Purpose:Alternative recording methods have been tested to allow the electroretinogram (ERG) recording in uncooperative patients and/or patients with palpebral alterations, including recordings with skin electrodes. The purpose of this study was to compare ERG recorded with skin electrodes and well-established microfiber electrodes and to determine normative values of ERG parameters for recording with skin electrodes. Methods: Fifty healthy volunteers (17-26 years; mean 20.63 ± 2.01 years) participated in the study. A gold disk skin electrode was placed on the lower orbital rim of a randomly chosen eye. On the contralateral eye, a microfiber electrode was positioned in the lower conjunctival sac. Gold disc electrodes were positioned at the ipsilateral outer canthus of both eyes acting as reference electrodes for the creation of a potential difference. Two ground electrodes were placed on the lobe of each ear. ERGs were recorded according to the International Society of Clinical Electrophysiology Visual (ISCEV) protocol using the VERIS 5.1.9 system for data acquisition and analysis. Results: Both types of electrodes showed similar wave response morphologies. The implicit time of responses between the two electrodes was comparable. On peak-to-peak amplitude, skin electrode recordings showed an amplitude reduction of 61.4% for rod responses, 61.5% for maximal responses, 46.2% for oscillatory potentials, 57.4% for cone responses, and 54.4% for 30Hz-flicker responses, when compared with microfiber electrode recordings. Based on these findings, normative values for peak-to-peak amplitude and implicit time to be used as a reference for ERGs recorded with skin electrodes were determined. Conclusions: ERGs recorded with skin electrodes presented lower peak-to-peak amplitude compared with microfiber electrodes. However, using appropriate normative values, skin electrodes may be useful for specific target populations such as uncooperative infants and/or patients with ocular surface alterations.

show abstract

Section: Discussionsupporting

confidence: 93%

Full-field electroretinogram recorded with skin electrodes in normal adults

Salomão¹,

Pereira²,

Berezovsky³

2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

show abstract

“…In this present study, we show similar results using a red-on-blue stimulus. The flash luminance used in this study was adopted from a previous study in this laboratory 52 and was comparable to the flash luminance used by Miyata et al 28 This supports findings that the red-on-blue stimulus is effective for clinical evaluation of RGC function.…”

Section: Comparison Of Focal and Full-field Phnrssupporting

confidence: 84%

Electrophysiological ON and OFF Responses in Autosomal Dominant Optic Atrophy

Morny

Margrain

Binns

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

METHODS. Twelve participants from six families with OPA1 ADOA and 16 age-matched controls were recruited. Electrophysiological assessment involved pattern ERGs (PERGs), focal (208) and full-field long-duration (250 ms) flash ERGs using a red light-emitting diode flash on a rod-saturating blue background, and full-field brief (300 ls) xenon flash ERGs using a red filter over a continuous rod saturating blue background. Amplitudes and implicit times of the ERG components were analyzed and the diagnostic potential of each electrophysiological technique was determined by generating receiver operating characteristic (ROC) curves.RESULTS. Mean amplitudes of the N95 and all PhNRs, except the full-field PhNR ON , were significantly reduced in participants with ADOA (P < 0.01). Subtraction of the group-averaged focal ERG of ADOA participants from that of controls showed an equal loss in the focal PhNR ON and PhNR OFF components, whereas in the full-field ERG the loss in the PhNR OFF was greater than that in the PhNR ON component. The areas under the ROC curve (AUC) for the focal PhNR ON (0.92), focal PhNR OFF (0.95), and full-field PhNR OFF (0.83), were not significantly different from that of the PERG N95 (0.99).CONCLUSIONS. In patients with ADOA, the PhNR ON and PhNR OFF components are nearly symmetrically reduced in the long-duration ERG, suggesting that ON-and OFF-RGC pathways may be equally affected.

show abstract

“…The implicit time of the PhNR in the group-averaged traces was used for fixed time-point measurements of individual traces, even if this did not coincide with the exact trough of the PhNR on visual inspection. The mean implicit time of all their PhNR data for our age range (50-72 years) was 72 ms. Mortlock et al, 33 who also averaged their PhNR data, obtained a mean implicit time of 72 ms as well. Further analysis was based on amplitude at 72 ms as PhNR and also the PhNR/b-wave ratio.…”

Section: Phnrmentioning

confidence: 99%

Photopic Negative Response versus Pattern Electroretinogram in Early Glaucoma

Preiser¹,

Lagrèze

Bach³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

110

103

View full text Add to dashboard Cite

PURPOSE. Photopic negative response (PhNR) and pattern electroretinogram (PERG) are electrophysiological markers of retinal ganglion cell function; both are reduced in glaucoma. We compared PhNR and PERG in different stages of the disease.METHODS. Eleven eyes with preperimetric glaucoma (glaucomatous optic disc with normal field); 18 with manifest glaucoma; and 26 normals were included. We obtained PhNR (flash strength from 0.1-4 cdÁs/m 2 ) and steady-state PERG and analyzed PhNR amplitude (baseline to 72 ms trough); PhNR/ b-wave ratio; PERG amplitude; and PERG ratio (0.88/168).RESULTS. Identification of PhNR structure was only reliable ‡1 cdÁs/m 2 flash strength; amplitude and receiver operating characteristics (ROC) area under curve (AUC) changed little from 1 to 4 cdÁs/m 2 . Both PhNR and PERG (amplitude and ratio) were reduced in preperimetric and more so in manifest glaucoma. AUCs based on PhNR/PERG amplitudes were not significantly different from chance in preperimetric glaucoma (AUCs 0.61/0.59), but were significant in manifest glaucoma (0.78/0.76); ratios were significant in both glaucoma groups (0.80/0.73 and 0.80/0.79). In spite of that, PhNR ratio and PERG ratio were not significantly correlated (r ¼ 0.22 across all groups); an ROC based on a combination of both reached AUCs of 0.85/0.90 for preperimetric/manifest glaucoma.CONCLUSIONS. Both PhNR and PERG performed similarly to detect glaucoma; for both, ratios performed better than amplitudes. The PhNR has the advantage of not requiring clear optics and refractive correction; the PERG has the advantage of being recorded with natural pupils. (Invest Ophthalmol Vis Sci.

show abstract

Inter-subject, inter-ocular and inter-session repeatability of the photopic negative response of the electroretinogram recorded using DTL and skin electrodes

Cited by 55 publications

References 37 publications

Full-field electroretinogram recorded with skin electrodes in normal adults

Full-field electroretinogram recorded with skin electrodes in normal adults

Electrophysiological ON and OFF Responses in Autosomal Dominant Optic Atrophy

Photopic Negative Response versus Pattern Electroretinogram in Early Glaucoma

Contact Info

Product

Resources

About