Inter-tablet coating variability: Residence times in a horizontal pan coater

Kalbag, Arjun; Wassgren, Carl; Penumetcha, Sai Sumana; Pérez-Ramos, José D.

doi:10.1016/j.ces.2008.03.009

Cited by 74 publications

(35 citation statements)

References 24 publications

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“…On the process side, imaging techniques have been employed to study the dynamic characteristics of the tablets in a rotary coating pan [10]. Inter-tablet coating variability within the spray zone in a coating pan has been studied using both experimental and discrete element modeling-based numerical methods [11]. A number of modeling techniques have been employed to study, predict, and improve content uniformity among tablets [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

et al. 2011

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A laser-induced breakdown spectroscopy-based analytical methodology is developed to study tablet coating variability in pharmaceutical tablets. The method quantifies the amount of coating on a tablet by assigning an average coating thickness score to it. When tested using samples with different amounts of coating, the coating thickness scores showed direct correlation to the weight gain of the tablet, hence validating the analytical method. The relative significance of the processing parameters and the components of variability were computed using statistical techniques. The sampling frequency of laser shots was found to have no significant effect. The effect of the position of the laser pulse on the tablet surface was found to be significant; however, it was determined that this effect was due to the tablet curvature, which resulted in the laser optical path to intersect the coating diagonally. The variability between batches (lots) manufactured under the same processing conditions was not significant. The largest avoidable source of variability was the tablet-to-tablet component, possibly indicating the inadequate mixing performance of the coating device.

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Section: Introductionmentioning

confidence: 99%

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

et al. 2011

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“…With an increasing CoF, mixing and the dimensionless appearance frequency increased (31). The impact of the CoF on the dynamic angle of repose was also investigated.…”

Section: Coefficient Of Frictionmentioning

confidence: 99%

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

et al. 2013

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Abstract. Coating of solid dosage forms is an important unit operation in the pharmaceutical industry. In recent years, numerical simulations of drug manufacturing processes have been gaining interest as process analytical technology tools. The discrete element method (DEM) in particular is suitable to model tabletcoating processes. For the development of accurate simulations, information on the material properties of the tablets is required. In this study, the mechanical parameters Young's modulus, coefficient of restitution (CoR), and coefficients of friction (CoF) of gastrointestinal therapeutic systems (GITS) and of activecoated GITS were measured experimentally. The dynamic angle of repose of these tablets in a drum coater was investigated to revise the CoF. The resulting values were used as input data in DEM simulations to compare simulation and experiment. A mean value of Young's modulus of 31.9 MPa was determined by the uniaxial compression test. The CoR was found to be 0.78. For both tablet-steel and tablet-tablet friction, active-coated GITS showed a higher CoF compared with GITS. According to the values of the dynamic angle of repose, the CoF was adjusted to obtain consistent tablet motion in the simulation and in the experiment. On the basis of this experimental characterization, mechanical parameters are integrated into DEM simulation programs to perform numerical analysis of coating processes.

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“…Additional studies using DEM simulations to analyze tablet coating processes were performed by Pandey et al [130], Kalbag et al [131], Kalbag and Wassgren [132], Sahni and Chaudhuri [133], and Sahni et al [134]. Pandey et al [135] reviewed applications of DEM and other modeling techniques for pancoating processes.…”

Section: Tablet Coatingmentioning

confidence: 97%

Discrete Element Modeling of Solid Dosage Manufacturing Processes

Barrasso

Ramachandran

2016

Methods in Pharmacology and Toxicology

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Solid dosage manufacturing primarily involves powder process operations, such as mixing, granulation, and compaction. A model-based approach can be used to develop a better scientific understanding of these processes and implement Quality by Design. These models must predict the critical quality attributes of the product based on process parameters, equipment geometry, and material properties. Discrete element modeling (DEM) is often used to capture mechanistic, particle-scale information, such as velocity and force profiles. In this chapter, recent literature studies that use the DEM to model solid dosage manufacturing processes will be presented and discussed.

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Inter-tablet coating variability: Residence times in a horizontal pan coater

Cited by 74 publications

References 24 publications

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

Discrete Element Modeling of Solid Dosage Manufacturing Processes

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