Inter-tablet coating variability: Tablet residence time variability

Kalbag, Arjun; Wassgren, Carl

doi:10.1016/j.ces.2009.02.037

Cited by 75 publications

(63 citation statements)

References 20 publications

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“…These results were consistent with previous examinations on the sensitivity of DEM simulations which showed that variations in Young's modulus and shear modulus, respectively, did not impact the dynamic angle of repose (12,22). In contrast, an influence of the CoF on the dynamic angle of repose was seen (19,21).…”

Section: Dem Simulationsupporting

confidence: 82%

“…Ketterhagen demonstrated that an increase in shear moduli by the factor of 100 had no impact on the results of the simulation (12). For the DEM simulation of a coating process of biconvex tablets, the coefficient of sliding friction had a distinct effect on the inter-tablet coating variability as well as on the qualitative appearance of the bed behavior (going from slumping to rolling with increasing friction) (21). In an investigation on the formation of glass bead "sand piles," the angle of repose was significantly sensitive to variations on the friction, while it was not sensitive to elasticity parameters in both experiment and simulation (22).…”

Section: Introductionmentioning

confidence: 99%

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Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

et al. 2013

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Abstract. Coating of solid dosage forms is an important unit operation in the pharmaceutical industry. In recent years, numerical simulations of drug manufacturing processes have been gaining interest as process analytical technology tools. The discrete element method (DEM) in particular is suitable to model tabletcoating processes. For the development of accurate simulations, information on the material properties of the tablets is required. In this study, the mechanical parameters Young's modulus, coefficient of restitution (CoR), and coefficients of friction (CoF) of gastrointestinal therapeutic systems (GITS) and of activecoated GITS were measured experimentally. The dynamic angle of repose of these tablets in a drum coater was investigated to revise the CoF. The resulting values were used as input data in DEM simulations to compare simulation and experiment. A mean value of Young's modulus of 31.9 MPa was determined by the uniaxial compression test. The CoR was found to be 0.78. For both tablet-steel and tablet-tablet friction, active-coated GITS showed a higher CoF compared with GITS. According to the values of the dynamic angle of repose, the CoF was adjusted to obtain consistent tablet motion in the simulation and in the experiment. On the basis of this experimental characterization, mechanical parameters are integrated into DEM simulation programs to perform numerical analysis of coating processes.

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Section: Dem Simulationsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

et al. 2013

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“…More recently, it has been used to address the coating uniformity of pharmaceutical tablet coating in pan coaters [2][3][4][5][6][7][8][9][10]. There are two critical parameters for the analysis of the coating variability: inter-and intra-particle coating variability.…”

Section: Introductionmentioning

confidence: 99%

“…There are two critical parameters for the analysis of the coating variability: inter-and intra-particle coating variability. The former is the variation in the average coating mass from a granule to another, whilst the latter is the distribution of coating liquid on the surfaces of individual granules, both of which can be quantified using the coefficient of variation [3].…”

Section: Introductionmentioning

confidence: 99%

Distinct element analysis of inter-particle coating variability in a batch seed coater

et al. 2017

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Abstract. Coating of particulate solids by a thin film layer is of interest in many industrial applications such as seed and tablet coating. In seed processing, seeds are commonly coated with a protective coating layer consisting of fertilisers and crop protection products. Rotary drum batch coaters are typically used for this purpose. The coater consists of a cylindrical vessel with a rotating spray disk in the centre, onto which the coating liquid is fed. The seeds are driven around the vessel by its rotating base, and are mixed by two baffles; one on either side of the vessel. In the present study, DEM simulations are used to analyse the seed coating process. Corn seed is used as a model material and its shape is captured using X-Ray microtomography (XRT). The shape is incorporated into the simulations by the clumping multiple spheres to form a particle assembly. The coating uniformity of the seeds is predicted by implementing a coating model, whereby the coating mechanism is represented in the DEM by considering that once a droplet contacts a corn seed, it is removed from the simulation and its mass is attributed to the coating mass of the corn seed. The distribution of mass of sprayed spheres on the corn seeds and the coefficient of variation are evaluated for a range of process conditions, such as spinning disk rotational speed, droplets size and baffle arrangement and designs. In addition to evaluation of coating uniformity of particles, the scale-up rules for rotary drum batch coaters are investigated and reported. The outcome provides guidelines on scale-up rules and improvement of coating uniformity for rotary batch seed coaters.

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“…Inter-and intra particle coating variability are the two parameters for assessing the coating variability. The former is the variation in the average coating mass from a granule to another, whilst the latter is the distribution of coating liquid on the surfaces of individual granules, in which both M a n u s c r i p t factors can be quantied using the coecient of variation [6]. Inter particle coating variability is dened as the coecient of variation of the coating mass amongst the particles.…”

Section: Introductionmentioning

confidence: 99%

Inter-particle coating variability in a rotary batch seed coater

Pasha¹,

Hare²,

Ghadiri³

et al. 2017

Chemical Engineering Research and Design

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A c c e p t e d M a n u s c r i p t  The coating uniformity of corn seeds in a batch seed coater is evaluated by DEM  Discrete drop coating model is used to evaluate the coating uniformity of the seeds  Effect of process parameters on coating uniformity of the seeds is investigated  The atomiser disk position is strongly influencing the coating uniformity  Optimum process parameters for rotary batch seed coaters are reported Research HighlightsPage 3 of 42

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Inter-tablet coating variability: Tablet residence time variability

Cited by 75 publications

References 20 publications

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

Distinct element analysis of inter-particle coating variability in a batch seed coater

Inter-particle coating variability in a rotary batch seed coater

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