Interacciones medicamentosas en pacientes de un servicio de medicina interna

Ibáñez, Ana Belén Pereira; Castell, María Victoria; García, J C; E, Puche

doi:10.1016/s1130-6343(08)75950-6

Cited by 16 publications

(9 citation statements)

References 12 publications

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“…In this study, the average of medications per prescription was similar to that found by Hammes and colleagues (2008) and Ibáñez (2009). The existence of multiple diseases in patients hospitalized in ICUs has contributed significantly to the increased use of polypharmacy in recent years, which favors a higher incidence of DI and therapeutic duplicity (Cruciol-Souza, Thomson, 2006;Bleich et al, 2009;Locatelli et al, 2010).…”

Section: Discussionsupporting

confidence: 87%

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

2015

J App Pharm Sci

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It is estimated there are thousands of combinations of drugs, which may generate various adverse drug events, including drug interactions (DI). To assess the contribution of pharmacist to identification and management of DI in an intensive care unit (ICU). A longitudinal study was conducted in the ICU of a private hospital in the city of Aracaju-SE, between 2008 and 2009. The prevalence and clinical relevance of DI was assessed by two clinical pharmacists. Demographic data and clinical information of patients hospitalized in the period of the study were obtained from medical records. At the end of the study 137 medical records were analyzed, with a predominance of female patients (55.4%), average age of 66 (±7.0) years. 6,085 prescriptions were collected during the study period, in which 2,455 drugs prescribed. Of these, 175 prescriptions contained clinically relevant DI, 178 of moderate severity and 35 of major severity, 213 DI in total. The clinical pharmacists prepared reports for the physicians, which enabled the reduction of 40% of all DI. Data from this study suggest that pharmacist's contribution may have reduced the incidence of DI, providing more familiarity of physicians on clinically relevant information and improving the quality of prescriptions in the ICU.

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Section: Discussionsupporting

confidence: 87%

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

2015

J App Pharm Sci

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“…In every DDI, we should distinguish between the molecule which is at the origin of an interaction (that is to say modifying the other drugs' concentration and action) and the molecule whose altered concentration, resulting from the same interaction, ultimately leads to the desired or undesired effects (in the case of a narrow therapeutic index drug) [ 2 ]. Various studies have shown that adverse drug reactions are responsible of 0.5% to 2% of consultations in ambulatory medicine and are involved in 4% to 10% of hospitalizations [ 3 , 4 ]. It has been estimated that 1/3 of the severe adverse effects are due to negligence and thus can be preventable; 20% of these side effects are caused by DDIs [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Detection and analysis of drug�drug interactions among hospitalized cardiac patients in the Mohammed V Military Teaching Hospital in Morocco

Fettah¹,

Moutaouakkil²,

Sefrioui³

et al. 2018

Pan Afr Med J

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IntroductionDrug-drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. Patients with cardiovascular disorders are at higher risk for DDIs because of the types and number of drugs they receive. The aim of the present study was to assess the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco.MethodsA prospective observational study from June 2016 to September 2016 was carried out in the cardiology department of a hospital in Morocco. Those patients who were taking at least two drugs and had a hospital stay of at least 48 hours were included in the study. The medications of the patients were analysed for possible interactions. All the prescriptions of the study population were screened for drug-drug interactions using a computerized DDI database system (Theriaque®).ResultsDuring the study period, 138 patients were included; 360 interactions were detected among 94 patients, with an average number of drugs taken of 5.2. The prevalence of DDIs was estimated at 68.11%, the most common of which concerned Kardegic/Plavix (12.22%), Kardegic/Heparin (8.33%), and Lasilix/Spironolactone (5.83%). Among the 726 prescribed drugs, (372 [51.24%]) were drugs of the cardiovascular system, followed by blood and hematopoietic organ drugs (288 [39.67%]) according to the Anatomical Therapeutic Chemical Classification codes. These interactions were categorized on the basis of level of severity: interactions with major severity accounted for 11.11% (40) of the total DDIs while those with moderate and minor severity accounted for 37.22% (134) and 51.66% (186), respectively.ConclusionThis study reports the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco. This study shows that DDIs are frequent among hospitalized cardiac patients and highlights the need to screen prescriptions of cardiovascular patients for possible DDIs, as this helps in their detection and prevention.Pan African Medical Journal – ISSN: 1937- 8688 (www.panafrican-med-journal.com)Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net)Pan African Medical Journal – ISSN: 1937- 8688 (www.panafrican-med-journal.com)Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net)

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“…Acetylsalicylic acid (Aspirin) decreases diuretic action and increases the risk of digitalis poisoning, me- tamizole decreases hypoglycemic effects, while some antihypertensive and anti-emetic agents, as well as concurrent use of inhibitors of angiotensin converting enzyme with potassium-sparing, increase the risk of hyperkalemia (Ibáñez et al, 2008;José et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Drug use by elderly inpatients of a philanthropic hospital

Santos

Sette

Belém

2011

Braz. J. Pharm. Sci.

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The high incidence of chronic diseases in the elderly leads to increased intermittent drug therapies. The presence of concomitant diseases and prescriptions made out by various health professionals facilitate the practice of polypharmacy, the emergence of iatrogenic diseases, and therapeutic regimens that are inconvenient for patients. The present study was carried out among elderly patients hospitalized at the Hospital Care Foundation of Paraiba, Campina Grande, with the objectives of studying the consumption of drugs by these patients, noting the possible adverse drug reactions (ADR), drug interactions and the presence of high-risk drugs prescribed to this age group. The study had a descriptive and cross-sectional quantitative design and involved a sample of 65 patients accompanied by the Pharmacovigilance Centre of the hospital, from August 2009 to July 2010. Over 90% of the patients were on polypharmacy, and the possible ADR found were related to the gastrointestinal tract where the most frequent interactions were with cardiovascular drugs. Within the context of pharmacoepidemiology, pharmacists can contribute by improving the quality of life of patients and preventing unnecessary expense with erroneous and poorly evaluated treatments. Uniterms:Elderly patients/drugs use. Polypharmacy. Drugs/adverse reactions. Drug interactions.A elevada incidência de doenças crônicas na terceira idade induz ao aumento de terapias medicamentosas intermitentes. A presença de patologias concomitantes e prescrições elaboradas por diversos profissionais de saúde facilitam a prática da polifarmácia, surgimento de doenças iatrogênicas e esquemas terapêuticos pouco cômodos para o paciente. O estudo foi realizado junto aos pacientes idosos internados no Hospital da Fundação Assistencial da Paraíba (FAP), Campina Grande, com objetivo de estudar o consumo de medicamentos por estes pacientes, observando as possíveis reações adversas a medicamentos (RAM), interações medicamentosas apresentadas e a presença de medicamentos de alto risco prescritos para este grupo etário. A pesquisa foi descritiva e transversal, com abordagem quantitativa, constituída por uma amostra de 65 pacientes, acompanhados através do Centro de Farmacovigilância do hospital, no período de agosto de 2009 a julho de 2010. Mais de 90% dos pacientes estavam sob polifarmácia, as possíveis RAM encontradas estavam mais relacionadas ao trato gastrintestinal e as interações foram mais frequentes com os medicamentos de ação cardiovascular. Dentro do contexto da farmacoepidemiologia, o profissional farmacêutico pode contribuir para a melhoria da qualidade de vida dos pacientes e evitar gastos desnecessários devido à terapêuticas errôneas e mal avaliadas.Unitermos: Terceira Idade/uso de medicamentos. Polifarmácia. Medicamentos/reação adversa. Interação medicamentosa.

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Interacciones medicamentosas en pacientes de un servicio de medicina interna

Abstract: Drug interaction is a serious clinical problem which requires the availability of more in depth information and medical attention.

Cited by 16 publications

References 12 publications

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

Pharmaceutical intervention assessment in the identification and management of drug interactions in an intensive care unit

Detection and analysis of drug�drug interactions among hospitalized cardiac patients in the Mohammed V Military Teaching Hospital in Morocco

Drug use by elderly inpatients of a philanthropic hospital

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