Interações medicamentosas em prescrições de idosos hipertensos: prevalência e significância clínica

Pinto, Natalia; Vieira, Liliana Batista; Pereira, Fernanda Maria Vieira; Reis, Adriano Max Moreira; Cassiani, Sílvia Helena De Bortoli

doi:10.12957/reuerj.2014.7111

Cited by 16 publications

(29 citation statements)

References 7 publications

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“…The association between polypharmacy and the occurrence of DI corroborates other Brazilian studies 11,33 . Thus, as DI is a constant risk, especially among elderly people who use polypharmacy, knowledge about the subject is vital in order to avoid greater risks to the health of these individuals 11 .…”

Section: Discussionsupporting

confidence: 90%

“…Similar results in relation to the severity of DI were obtained in studies of the elderly in the community in Ribeirão Preto (São Paulo) 33 , in Timóteo (Minas Gerais) 9 , and among elderly patients attending the geriatric outpatient clinic at the Hospital Universitário de Belém (Pará), in which the majority had moderate severity.…”

Section: Discussionsupporting

confidence: 81%

“…The lack of cost-effective therapeutic alternatives with a safer profile for these individuals in public health adds to this risk 27 . to the severity and prevalence of possible DI 33 . The association between the presence of possible DI and age found in the present study diverged from an investigation of elderly persons living in the community in the city of Rio de Janeiro 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Misuse of medicines in the elderly is a significant public health The frequency of potential DI did not differ from that described in scientific literature. These values can vary greatly and high prevalence is found among the elderly 9,33 .…”

Section: Discussionmentioning

confidence: 99%

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Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis ( p<0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/ partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range ( p=0.005), polypharmacy ( p<0.001) and use of potentially inappropriate medications ( p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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“…Com o avançar da idade, as pessoas acabam desenvolvendo doenças crônicas e acabam utilizando uma grande quantidade de medicamentos, os quais podem trazer benefícios quando usados corretamente pelo paciente, e podem trazer prejuízos se não utilizados adequadamente 17 . A população idosa caracteriza-se por possuir diversos problemas crônicos de saúde e utilizar vários medicamentos, sendo na sua maioria polimedicados.…”

Section: Tratamentos Realizadosunclassified

Itinerário terapêutico de idosas com lombalgia crônica

Debiasi

Zeni

Gauer

et al. 2017

RFS

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ResumoIntrodução: Nas últimas décadas o Brasil envelheceu e a maior parte dessa população carrega consigo doenças próprias do envelhecimento. Dentre as doenças crônicas que mais acometem os idosos, destaca-se a lombalgia crônica, que é um quadro de dor que gera desconforto. Objetivo: Identificar o itinerário terapêutico de idosas com lombalgia crônica. Materiais e métodos: Pesquisa qualitativa que utilizou entrevista com questões norteadoras na coleta de dados. Foi realizada análise de conteúdo temática a partir de três etapas: pré-análise, exploração de material, tratamento dos resultados e interpretação. Resultados: Foram selecionadas 4 idosas com cognitivo preservado, média de idade de 63,5 anos e 8,75 anos de diagnóstico médico de lombalgia. Após análise, emergiram 5 categorias que detalharam o processo de busca por tratamento para a dor crônica lombar, desde os sintomas até a fase atual. Considerações finais: Conhecer o itinerário terapêutico de idosas com dor crônica lombar constituiu-se numa estratégia para ampliar as informações sobre as dificuldades enfrentados na busca pelo tratamento, e como estabelecer uma ação mais eficaz para a saúde destas pessoas. Palavras-chaveDor lombar; Idosos; Terapêutica.Itinerário terapêutico de idosas com lombalgia crônica Debiasi L, Zeni JRO, Gauer APM, Ferretti F Fisi enectusAno 4, n. 1 -Jan/Jun. 2016 13Abstract Introduction: In recent decades, Brazil ages and most of this population carries with it own diseases of aging. Among chronic diseases that most affect the elderly, there is chronic low back pain, which is a painful condition that causes discomfort. Objective: The study aims to identify the therapeutic itinerary of elderly with chronic low back pain. Materials and methods: Qualitative research used the interview with guiding questions to collect data. The thematic content analysis from three pre-analysis steps, exploitation material, processing of results and interpretation. Results: 4 elderly women with preserved cognitive, mean age of 63.5 years and 8.75 years of medical diagnosis were selected. After analysis, five categories emerged that detailed the search process by treatment for chronic low back pain. Final considerations: Knowing the therapeutic itinerary of elderly with low back pain is chronic in a strategy to expand the information on difficulties experienced in the process and a way to reflect on the care offered, and how to establish a more effective action for the health of these people.

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City-wide electronic health records reveal gender and age biases in administration of known drug–drug interactions

et al. 2019

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The occurrence of drug–drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level. We present a large-scale longitudinal study (18 months) of the DDI phenomenon at the primary- and secondary-care level using electronic health records (EHR) from the city of Blumenau in Southern Brazil (pop. ≈340,000). We found that 181 distinct drug pairs known to interact were dispensed concomitantly to 12% of the patients in the city’s public health-care system. Further, 4% of the patients were dispensed drug pairs that are likely to result in major adverse drug reactions (ADR)—with costs estimated to be much larger than previously reported in smaller studies. The large-scale analysis reveals that women have a 60% increased risk of DDI as compared to men; the increase becomes 90% when considering only DDI known to lead to major ADR. Furthermore, DDI risk increases substantially with age; patients aged 70–79 years have a 34% risk of DDI when they are dispensed two or more drugs concomitantly. Interestingly, a statistical null model demonstrates that age- and female-specific risks from increased polypharmacy fail by far to explain the observed DDI risks in those populations, suggesting unknown social or biological causes. We also provide a network visualization of drugs and demographic factors that characterize the DDI phenomenon and demonstrate that accurate DDI prediction can be included in health care and public-health management, to reduce DDI-related ADR and costs.

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Interações medicamentosas em prescrições de idosos hipertensos: prevalência e significância clínica

Abstract: RESUMO: O objetivo deste estudo foi analisar a prevalência e significância clínica de interações medicamentosas identificadas nas prescrições de pacientes idosos hipertensos. Trata-se de um estudo descritivo,

Cited by 16 publications

References 7 publications

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Itinerário terapêutico de idosas com lombalgia crônica

City-wide electronic health records reveal gender and age biases in administration of known drug–drug interactions

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