The second law of thermodynamics points to the existence of an 'arrow of time', along which entropy only increases. This arises despite the time-reversal symmetry (TRS) of the microscopic laws of nature. Within quantum theory, TRS underpins many interesting phenomena, most notably topological insulators [1][2][3][4] and the Haldane phase of quantum magnets [5,6]. Here, we demonstrate that such TRS-protected effects are fundamentally unstable against coupling to an environment. Irrespective of the microscopic symmetries, interactions between a quantum system and its surroundings facilitate processes which would be forbidden by TRS in an isolated system. This leads not only to entanglement entropy production and the emergence of macroscopic irreversibility [7,8], but also to the demise of TRS-protected phenomena, including those associated with certain symmetry-protected topological phases. Our results highlight the enigmatic nature of TRS in quantum mechanics, and elucidate potential challenges in utilising topological systems for quantum technologies.Many isolated systems possess features that rely on symmetries of their Hamiltonian. Most strikingly, in many-body systems the presence of symmetries leads to new phases of matter, including symmetry-protected topological phases (SPTs) [9,10]. SPTs exhibit many remarkable features, such as the emergence of topological bound states (e.g. Majorana zero modes [11]), which have potential applications in quantum information processing [12,13].An important practical question, which we address in this Letter, is whether symmetry-protected phenomena such as these can persist in realistic scenarios where the system is weakly coupled to an environment. Previous studies of topology in open systems begin with an approximate equation of motion for the system (e.g. non-Hermitian Hamiltonian [14] or Lindblad master equation [15][16][17]). Instead, our starting point is the full systemenvironment Hamiltonian