Interaction behaviour of trimesoyl chloride derived 1st tier dendrimers determined with structural and physicochemical properties required for drug designing

Undre, Sachin B.; Singh, Man; Kale, R.K.

doi:10.1016/j.molliq.2013.03.019

Cited by 23 publications

(9 citation statements)

References 26 publications

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“…TTDMM, TTDEM and TTDPM were synthesized according to procedures reported in our previous communication [22,23]. In brief dendrimers were synthesized by TMC core and sodium dialkyl malonate salt in 1:3 molar ratio in methanol in case of TTDMM and ethanol for the rest.…”

Section: Preparation and Characterization Of Dendrimers And Drug-dendmentioning

confidence: 99%

“…Despite such extraordinary structural capabilities for MTX binding, no specific and systematic research work with TTDMM, TTDEM and TTDPM has ever been reported so far; hence our study on developing models of dendrimer-drug designing is aimed to provide an advance understanding of complexities of drug-carrier interfaces. The green method for divergent synthesis and characterization of TTDMM, TTDEM and TTDPM was reported in our previous communication [22,23]. Therefore, in this study, TTDMM, TTDEM and TTDPM with a trimesoyl chloride (TMC) core and variable dialkyl malonate esters as branching units with well-defined size were synthesized and used as drug carrier for better encapsulation of anticancer drug.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of increasing alkyl chain of 1st tier dendrimers on binding and release activities of methotrexate drug: An in vitro study

Tondwal

Singh

2015

Journal of Molecular Liquids

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Section: Preparation and Characterization Of Dendrimers And Drug-dendmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of increasing alkyl chain of 1st tier dendrimers on binding and release activities of methotrexate drug: An in vitro study

Tondwal

Singh

2015

Journal of Molecular Liquids

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“…Till date, numerous advanced research investigations have been reported through the application of this instrument and those too, in the diverse fields of organometallic chemistry, formulation validation, interaction chemistry and several others [104][105][106][107][108][109][110]. Since the instrument has a manual approach, it therefore leaves a very little scope for human error to alter or interfere with the corresponding measurement and therefore, presents a highly well-suited technique for analysis at the nanoscale.…”

Section: Risk Assessmentmentioning

confidence: 99%

Biomedical Nanotoxicology and Concerns with Environment: A Prospective Approach for Merger with Green Chemistry Enabled Physicochemical Characterization

Malik¹,

Mukherjee²,

Singh³

2015

J Microb Biochem Technol

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Of late, nanotechnology has emerged to be a very reliable bridge in trying to club salient fields of natural sciences on a common platform. Deservedly enough, nanomaterials have enabled numerous unconventional wonders to be accomplished through their incorporation, either on a singular or on complexed form. However, the rapid strides being accomplished on a tremendously high speed have sheerly ignored some ground realities in terms of ethical considerations. Bestowed with unconventional physicochemical properties and material behavior, nanomaterials are often surprise candidates in terms of their interaction with several other materials. This leads to a significant difficulty in the discard of integrated structures or individual materials carrying nanomaterials. The emerging threat of nanotoxicology from interactions thereof has attracted significant attention of environmental conservationists from the different corners of the world. In terms of physicochemical behavior, it is extremely essential to have a sound knowledge of the nanomaterial behavior and probable risk assessment. With this background, this review article sheds light on the behavioral aspects of nanomaterials with a comprehensive recalling of the case studies. The propositions of novel invention from Indian soil, Survismeter, friccohesity and tentropy have been made for further strengthening the risk assessment of nanomaterials.

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“…Dendrimers have some proven applications and numerous potential applications. Dendrimers are relatively monodispersed and highly branched macromolecules with controlled composition and architecture consisting of three components (Figure 2(a)): a central core, interior branch cells or radial symmetry, and terminal branch cell or peripheral group [23]. Dendrimers have many void spaces for their interaction of other substances Figure 2(b) [24].…”

Section: Dendrimers In Bioremediationmentioning

confidence: 99%

Ecofriendly Application of Nanomaterials: Nanobioremediation

Rizwan

Singh

Mitra

et al. 2014

Journal of Nanoparticles

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169

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Nanomaterials exhibit unique physical and chemical properties and, hence, they have received much attention from scientists and researchers in different areas of environmental sciences, specifically in bioremediation. Bioremediation provides a good clean-up strategy for some types of waste, but as it is expected, it will not be useful for all. For example, bioremediation may not provide a feasible strategy at sites with high concentrations of chemicals that are toxic to most microorganisms. These include heavy metals and salt. Further, the advancement in science and technology has increased standard of living which directly or indirectly contributes to the increase in waste and toxic material. Therefore, the remediation of contaminants by use of existing technology is not effective and efficient in cleaning up the environment. Hence, nanomaterials may be applied for bioremediation, which will not only have less toxic effect on microorganisms, but will also improve the microbial activity of the specific waste and toxic material which will reduce the overall time consumption as well as reduce the overall cost. In this paper we have briefly summarized the major types of nanomaterials that have been used so far in bioremediation of waste and toxic materials.

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Interaction behaviour of trimesoyl chloride derived 1st tier dendrimers determined with structural and physicochemical properties required for drug designing

Cited by 23 publications

References 26 publications

Effect of increasing alkyl chain of 1st tier dendrimers on binding and release activities of methotrexate drug: An in vitro study

Effect of increasing alkyl chain of 1st tier dendrimers on binding and release activities of methotrexate drug: An in vitro study

Biomedical Nanotoxicology and Concerns with Environment: A Prospective Approach for Merger with Green Chemistry Enabled Physicochemical Characterization

Ecofriendly Application of Nanomaterials: Nanobioremediation

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