Interaction between Anesthetics and the Sodium-Hydrogen Exchange Inhibitor HOE 642 (Cariporide) in Ischemic and Reperfused Rat Hearts

Mathur, Sanjiv; Karmazyn, Morris

doi:10.1097/00000542-199712000-00025

Cited by 36 publications

(6 citation statements)

References 29 publications

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“…Our present results are well coincident with previous studies by using inhaled anaesthetics in CABG or paediatric cardiac surgery [1, 2, 4, 20, 26, 27]. Studies have reported that the cardioprotection mechanism of inhaled anesthetics such as, volatile anesthetics open intracellular K ATP channels, activate adenosine receptors, and inhibit Na + /K + pump [1, 8, 28, 29]. Studies have also reported that the cardioprotection mechanism of propofol is related to its anti-inflammatory, immunomodulatory and antioxidant properties [21, 30, 31].…”

Section: Discussionsupporting

confidence: 91%

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Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

et al. 2017

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BackgroundThis study aimed to compare myocardial protective effects of anaesthesia with intravenous infusion of propofol versus inhalation of sevoflurane in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.MethodsSeventy-six patients undergoing valve replacement with cardiopulmonary bypass were randomly assigned to propofol or sevoflurane anesthesia during the surgery, respectively. For assessing myocardial injury, cardiac troponin I (cTnI) and creatine kinase isozyme (CK-MB) were determined before induction (T0), 0.5 h (T1) and 3 h (T2) after aortic unclamping, and 24 h (T3) and 48 h (T4) after surgery. The concentrations of interleukin (IL)-6 and IL-10 as the systemic inflammatory and anti-inflammatory markers were also measured at above time points.ResultsIn the sevoflurane group, the plasma concentrations of cTnI and CK-MB from Tl to T4 and the levels of IL-6 and IL-10 from T1 to T2 were lower than those in the propofol group. Moreover, a higher ratio of automatic heart beat recovery and a shorter length of intensive care unit or hospital stay were found in the sevoflurane group comparing with the propofol group.ConclusionSevoflurane anaesthesia produced more prominent myocardial protection and attenuated inflammatory response than propofol anaesthesia in patients with valve replacement surgery under cardiopulmonary bypass, resulting in shorter ICU and in-hospital stay.Retrospective clinical trial registrationIdentified as ChiCTR-IOR-16009979 at http://www.chictr.org.cn/.

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Section: Discussionsupporting

confidence: 91%

“…It is well-known that CPB and operative procedure often evoke a nonseptic systemic inflammatory reaction, with the potential risk of postoperative cardiac dysfunction [29, 30, 35]. The anti-inflammatory potential of sevoflurane has been reported in lots of CABG surgeries under CPB [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

et al. 2017

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“…Conversely, in an isolated perfused rat heart model, sufentanil did not improve post-ischaemic recovery, but produced an increase in left ventricular end-diastolic pressure during reperfusion. 63 The clinical relevance of opioid-induced cardioprotection is not yet clear. This topic will be discussed in Part II of this review.…”

Section: Opioidsmentioning

confidence: 99%

Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms

Zaugg

Lucchinetti

Uecker

et al. 2003

British Journal of Anaesthesia

229

142

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Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischaemic damage. Major milestones regarding the elucidation of this phenomenon have been passed in the last two decades. The signalling and amplification cascades from the preconditioning stimulus, be it ischaemic or pharmacological, to the putative end-effectors, including the mechanisms involved in cellular protection, are discussed in this review. Volatile anaesthetics and opioids effectively elicit pharmacological preconditioning. Anaesthetic-induced preconditioning and ischaemic preconditioning share many fundamental steps, including activation of G-protein-coupled receptors, multiple protein kinases and ATP-sensitive potassium channels (K(ATP) channels). Volatile anaesthetics prime the activation of the sarcolemmal and mitochondrial K(ATP) channels, the putative end-effectors of preconditioning, by stimulation of adenosine receptors and subsequent activation of protein kinase C (PKC) and by increased formation of nitric oxide and free oxygen radicals. In the case of desflurane, stimulation of alpha- and beta-adrenergic receptors may also be of importance. Similarly, opioids activate delta- and kappa-opioid receptors, and this also leads to PKC activation. Activated PKC acts as an amplifier of the preconditioning stimulus and stabilizes, by phosphorylation, the open state of the mitochondrial K(ATP) channel (the main end-effector in anaesthetic preconditioning) and the sarcolemmal K(ATP) channel. The opening of K(ATP) channels ultimately elicits cytoprotection by decreasing cytosolic and mitochondrial Ca(2+) overload.

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“…1,3,4 Conversely, inhibition of the exchanger by ca- riporide during ischemia will attenuate intracellular accumulation of Na ϩ and Ca ϩ in cardiomyocytes and diminish rigor contracture during ischemia and reperfusion. 4 The beneficial effects of cariporide during regional ischemia include reduction of infarct size, 4,21 improved postmyocardial infarction LV function, 22 reduced apoptosis, 23 reduced ATP preservation, 24 and reduced auricular and ventricular arrhythmias during reperfusion by reducing the refractory period. 6,7 In the surgical setting cariporide increases tolerance to global ischemia and reperfusion, 21 can be given before ischemia, and might become more efficient than ischemic preconditioning.…”

Section: Discussionmentioning

confidence: 99%

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange

Castellà

Tan

Ignarro

2002

The Journal of Thoracic and Cardiovascular Surgery

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These observations show that adjunctive pretreatment with cariporide delays myocardial and endothelial injury during ischemia and reperfusion, limits oxygen-derived radical injury, restores function, reduces edema, and preserves endothelin and nitric oxide balance at normal values. The myeloperoxidase changes show that less white blood cell adherence supports reduced reperfusion endothelial damage.

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Interaction between Anesthetics and the Sodium-Hydrogen Exchange Inhibitor HOE 642 (Cariporide) in Ischemic and Reperfused Rat Hearts

Cited by 36 publications

References 29 publications

Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange

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