Interaction between bromothymol blue and antipyrine in dichloromethane

Gainza, Alberto Hernandez; Jimenez, Luisa Puerta

doi:10.1139/v87-380

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2010

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“…Bromothymol blue is the most widely used dye for the determination of amines of pharmaceutical interest by photometric method (27,29 and references therein). The BTB forms a CT-ion pair complex with codeine.…”

Section: Resultsmentioning

confidence: 99%

Cloud point extraction and spectrophotometric determination of codeine in pharmaceutical and biological samples

Mashhadizadeh¹,

Jafari²

2010

JICS

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Cloud point extraction process using non-ionic surfactant, Triton X-114, to extract codeine from aqueous solution was investigated. The method was based on the extraction of codeine and bromothymol blue from acetate buffer media to surfactantrich phase and formed a charge transfer-ion pair complex. The extracted surfactant-rich phase was diluted with ethanol and its absorbance was measured at 430 nm. The effect of different variables such as pH, Triton X-114 concentration, cloud point temperature and time was established. The calibration graph was linear in a wide range of 100 -700 ng ml -1 of codeine with r = 0.998 (n = 7). The detection limit based on three times standard deviation of the blank (3s) was 4.6 ng ml -1 and relative standard deviation (R.S.D) is 2.15% for 500 ng ml -1 codeine (n = 5). The proposed method was applied to the determination of codeine in acetaminophen codeine tablets and blood samples.

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Section: Resultsmentioning

confidence: 99%