2023
DOI: 10.3390/biom13020258
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Interaction between Butyrate and Tumor Necrosis Factor α in Primary Rat Colonocytes

Abstract: Butyrate, a short-chain fatty acid, is utilized by the gut epithelium as energy and it improves the gut epithelial barrier. More recently, it has been associated with beneficial effects on immune and cardiovascular homeostasis. Conversely, tumor necrosis factor alpha (TNFα) is a pro-inflammatory and pro-hypertensive cytokine. While butyrate and TNFα are both linked with hypertension, studies have not yet addressed their interaction in the colon. Here, we investigated the capacity of butyrate to modulate a host… Show more

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Cited by 4 publications
(2 citation statements)
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“…Furthermore, a study demonstrated that L-NAME during hypoxia prevented events leading to mitochondrial DNA fragmentation and increased Bax/Bcl2 ratio [35]. Moreover, the literature reported that TNF-α can modulate the hypoxia-mediated apoptotic response, affecting the Bax/Bcl2 ratio [36,37].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, a study demonstrated that L-NAME during hypoxia prevented events leading to mitochondrial DNA fragmentation and increased Bax/Bcl2 ratio [35]. Moreover, the literature reported that TNF-α can modulate the hypoxia-mediated apoptotic response, affecting the Bax/Bcl2 ratio [36,37].…”
Section: Discussionmentioning
confidence: 99%
“…The beneficial effects are largely attributed to the anti-inflammatory properties of SCFAs, particularly butyrate. For instance, butyrate has been shown to modulate Tregs, reduce the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, promote the differentiation of M2 macrophages, and inhibit M1 macrophages and neutrophils [ 101 , 102 , 103 , 104 ].…”
Section: Microbial Metabolites: Established Players In Intestinal Hom...mentioning
confidence: 99%