Interaction between Chlorhexidine Digluconate and EDTA

Rasimick, Brian J.; Nekich, Michelle; Hladek, Megan M.; Musikant, Barry Lee; Deutsch, Allan S.

doi:10.1016/j.joen.2008.08.039

Cited by 78 publications

(81 citation statements)

References 25 publications

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“…Do Prado et al (7) It is important to emphasize that in the present study final irrigation of the root canals was performed with CHX just after using EDTA. Rasimick et al (24) observed that the interaction between chlorhexidine digluconate and EDTA forms a precipitate. However those authors did not evaluate the morphology of this precipitate.…”

Section: Strategies To Prevent Chemical Sl Formationmentioning

confidence: 99%

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

et al. 2017

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This study compared the effect of intermediate flush with distilled water delivered by conventional irrigation, EndoVac microcannula or Self-Adjusting File (SAF) system in the prevention of chemical smear layer (CSL) formation. Thirty human premolars were used. Canals were prepared with Reciproc system and 5.25% NaOCl. After chemomechanical preparation, samples were divided in 3 groups (n=10) according to the intermediate irrigation protocol with distilled water using: conventional irrigation, EndoVac microcannula or SAF. A final flush with 2% chlorhexidine solution was used and scanning electron microscopy was performed to assess protocol effectiveness. Two calibrated evaluators attributed scores according the presence or absence of CSL on the surface of the root canal walls at the coronal, middle and apical thirds, as follows: (1) no CSL; (2) small amounts of CSL; (3) moderate CSL; and (4) heavy CSL. Differences between protocols were analyzed with Kruskal-Wallis and Mann-Whitney U tests. Friedman and Wilcoxon signed rank tests were used for comparison between each root canal third. SAF resulted in less formation of CSL when compared with the conventional irrigation and EndoVac microcannula (p<0.05). When root canal thirds were analyzed, conventional irrigation and EndoVac groups showed less CSL formation at coronal and middle thirds in comparison to the apical third (p<0.05). In SAF group, there was no difference among the thirds (p>0.05). It may be concluded that an intermediate flush of distilled water, delivered by the SAF system resulted in a better reduction of CSL formation during chemomechanical preparation.

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Section: Strategies To Prevent Chemical Sl Formationmentioning

confidence: 99%

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

et al. 2017

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“…28 The NYS nanosystem was expected to show the same prolonged release profile as C3, but did not present any initial inhibition, formation of the degradation product p-chloroaniline and its subsequent precipitation. 29,30 No precipitation or incompatibility was observed between CHX and formulation excipients 48 hours after formulation preparation with pure CHX. Mouthwash formulations were produced with pure CHX and the inclusion complexes using 0.12% w/v CHX content.…”

Section: Development Of Inclusion Complexes In Oral Solutions and Stamentioning

confidence: 96%

Preparation and evaluation of antimicrobial activity of nanosystems for the control of oral pathogens Streptococcus mutans and Candida albicans

Cg¹,

Villardi²,

Cr³

et al. 2011

IJN

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Background Diseases that affect the buccal cavity are a public health concern nowadays. Chlorhexidine and nystatin are the most commonly used drugs for the control of buccal affections. In the search for more effective antimicrobials, nanotechnology can be successfully used to improve the physical chemical properties of drugs whilst avoiding the undesirable side effects associated with its use. Herein described are studies using nystatin and chlorhexidine with sodium montmorillonite (MMTNa), and chlorhexidine with β-cyclodextrin and two derivatives methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the development of antimicrobial nanosystems. Methods The nanosystems were prepared by kneading and solubilization followed by freeze-drying technique. The nanosystems were characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Nanosystem antimicrobial activity against Streptococcus mutans and Candida albicans strains was evaluated with inhibition halo analysis. Results The nanocarriers MMTNa and cyclodextrins showed good yields. XRPD, FTIR, and DSC analysis confirmed the proposed nanosystems formation and the suitability of the production methods. The nanosystems that showed best antimicrobial effect were chlorhexidine gluconate (CHX) and cyclodextrin inclusion complexes and CHX:MMTNa 60% cation exchange capacity – 24 hours. Conclusion The nanosystem formulations present higher stability for all chlorhexidine inclusion complexes compared with pure chlorhexidine. The nystatin nanosystems have the potential to mask the bitter taste, justifying subsequent in-vivo studies. For these reasons, further studies are being carried out to evaluate their application in professional formulations.

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“…Earlier studies have demonstrated the interactions between irrigating solutions like EDTA/CHX, EDTA/NaOCl, and NaOCl/CHX and their associated problems (7)(8)(9)(10). When EDTA and CHX were combined, there was formation of a precipitate (7).…”

Section: Sucess Of Endodontic Therapy Depends Upon Mechanical Instrummentioning

confidence: 99%

Chemical interaction of 7 % MA with 2 % CHX and 5 % Naocl – an in vitro study.

Chandak¹

2013

IOSR-JDMS

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Interaction between Chlorhexidine Digluconate and EDTA

Cited by 78 publications

References 25 publications

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

Preparation and evaluation of antimicrobial activity of nanosystems for the control of oral pathogens Streptococcus mutans and Candida albicans

Chemical interaction of 7 % MA with 2 % CHX and 5 % Naocl – an in vitro study.

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