Interaction between curcumin and mimetic biomembrane

Chen, Guifang; Chen, Yangyang; Yang, Nana; Zhu, Xuejun; Sun, Lizhou; Li, Genxi

doi:10.1007/s11427-012-4317-8

Cited by 34 publications

(31 citation statements)

References 22 publications

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“…The anodic current drop for a curcumin-loaded microemulsion in the highest curcumin concentration might be explained by other processes involved apart from curcumin diffusion (e.g., interaction with surfactants and oils). This observation is consistent with other works [55]. …”

Section: Resultssupporting

confidence: 94%

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Greenwald

Frušić-Zlotkin

Soroka

et al. 2017

Oxidative Medicine and Cellular Longevity

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Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system. Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure. We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin. A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion. Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.

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Section: Resultssupporting

confidence: 94%

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Greenwald

Frušić-Zlotkin

Soroka

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…The unsaturated ketone of curcumin undergoes a nucleophilic addition reaction as an acceptor, together with A-OH, A-SH, and A-SeH that sustain its interaction with multiple molecules [10]. Curcumin has also been suggested to change the properties of cell membranes in which its inserts and indirectly affect membrane-bound proteins [12,13]. The interaction of curcumin with artificial membrane (DOPC-based membranes) shows that it thinned the bilayer and weakened its elasticity modulus [14,15].…”

Section: Introductionmentioning

confidence: 99%

Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization

Oyanguren

Rainey

Moustapha

et al. 2020

Cells

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Curcumin, a major active component of turmeric (Curcuma longa, L.), is known to have various effects on both healthy and cancerous tissues. In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but the mechanism underlying the anticancer effect of curcumin is still unclear. Since there is a recent consensus about endoplasmic reticulum (ER) stress being involved in the cytotoxicity of natural compounds, we have investigated using Image flow cytometry the mechanistic aspects of curcumin’s destabilization of the ER, but also the status of the lysosomal compartment. Curcumin induces ER stress, thereby causing an unfolded protein response and calcium release, which destabilizes the mitochondrial compartment and induce apoptosis. These events are also associated with secondary lysosomal membrane permeabilization that occurs later together with an activation of caspase-8, mediated by cathepsins and calpains that ended in the disruption of mitochondrial homeostasis. These two pathways of different intensities and momentum converge towards an amplification of cell death. In the present study, curcumin-induced autophagy failed to rescue all cells that underwent type II cell death following initial autophagic processes. However, a small number of cells were rescued (successful autophagy) to give rise to a novel proliferation phase.

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“…It has a broad spectrum of antioxidant, anti-carcinogenic, anti-mutagenic and anti-inflammatory properties [2,4]. …”

Section: Introductionmentioning

confidence: 99%

Curcumin protection activities against γ-Rays-induced molecular and biochemical lesions

2013

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BackgroundCurcumin is a yellow-pigment phenolic compound used as a food spice and has a broad spectrum of antioxidant, anti-carcinogenic, anti-mutagenic and anti-inflammatory properties.MethodsRadio-protective efficacy of curcumin; diferuloylmethane (C21H20O6) was evaluated using molecular and biochemical assays in male mice after exposure to 3 Gy γ-rays. Curcumin was given at a dose of 400 μmol/ kg body weight via gastric tubes for 5 following days either pre-, post- or both pre- and post-exposure.ResultsThe incidence of aberrant cells and aberration types (mostly chromatids, breaks and fragments) was reduced with curcumin dosage as compared to irradiated group. Thiobarbituric acid reactive substances (TBARS), hydroperoxide (HP), xanthine oxidase (XO) and apoptotic markers (DNA- fragmentation and caspase-3 activation) were increased significantly, whereas levels of glutathione (GSH) and the enzymatic antioxidants [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] were significantly depleted in γ-irradiated mice. Curcumin treatments of mice groups including the 5 days pre-irradiation treated group (protected), the 5 days post-irradiation treated group (treated), and the curcumin treated group 5 days pre- and post-irradiation (protracted), have attenuated the liver toxic effects of γ-rays as manifested by reducing the levels of TBARS, HP, XO and DNA fragmentation. Curcumin has also rescued the depletion of GSH and the enzymatic-antioxidant status.ConclusionsCurcumin has significant radio-protective and radio-recovery activities in γ-irradiated mice. It has antioxidant potential against γ-rays-induced cytogenetic, molecular and biochemical lesions in mice.

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Interaction between curcumin and mimetic biomembrane

Cited by 34 publications

References 22 publications

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization

Curcumin protection activities against γ-Rays-induced molecular and biochemical lesions

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