Interaction between dyslipidaemia, oxidative stress and inflammatory response in patients with angiographically proven coronary artery disease

Abstract

IntroductionCoronary artery disease (CAD) is emerging as the biggest killer of the 21st century. A number of theories have been postulated to explain the aetiology of atherosclerosis. The present study attempts to elucidate the interaction, if any, between inflammation, oxidative stress and dyslipidaemia in CAD.MethodsA total of 753 patients undergoing angiography were evaluated and 476 were included in the study. The parameters studied included complete lipid profile, and apolipoprotein B, ferritin and nitric oxide (NO) levels. Statistical analysis was carried out to determine the interrelationship between these parameters and the best predictor of CAD risk. Cut-off points were determined from the receiver operating characteristics curves, and the specificity, sensitivity, positive predictive value, negative predictive value, odds ratio and confidence intervals were calculated.ResultsThe levels of the parameters studied increased with the stenotic state and a positive correlation was observed between ferritin, NO and apolipoprotein B. NO emerged as the most reliable predictor of CAD, with an area under the curve of 0.992 and sensitivity and specificity of 97 and 98%, respectively.ConclusionEnvironmental and genetic risk factors for CAD interact in a highly complex manner to initiate the atherosclerotic process. These risk factors should be considered mutually inclusive, not exclusive when devising pharmacological interventions, as multi-factorial risk management is the cornerstone of CAD management

The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease

“…Sleep-wake disturbances are strongly associated with cardiovascular diseases, such as coronary artery disease (CAD), and cardiovascular risk factors, including hypertension, diabetes, obesity, and smoking [ 1 , 2 ]. The mechanisms underlying the relationship between sleep and cardiovascular disease are not known; oxidative stress (OS), which is increased in CAD and in healthy adults with poor sleep, may be involved [ 3 , 4 , 5 , 6 ].…”

Dynamics of glutathione reductase activity in rat liver tissues during cryodestruction of the right atrium

“…Reactive oxygen species also damage vascular endothelium and reduce nitric oxide (II) secretion, which provokes endothelial dysfunction manifested by increased vasoconstriction, hypercoagulation and proliferation of muscle cells [4]. Reactive oxygen species destroy cell membranes, which leads to the formation of a large number of free radicals, which in turn damage cardiomyocytes, and as a result myocardial contractile function deteriorates [5,6]. Free radicals also trigger cardiomyocyte apoptosis and have a direct negative inotropic effect.…”