Interaction between Eudragit® E100 and anionic drugs: Addition of anionic polyelectrolytes and their influence on drug release performance

Indomethacin-containing interpolyelectrolyte complexes based on Eudragit® E PO/S 100 copolymers as a novel drug delivery system

“…According to the chemical structure of IND we can expect IND-EPO interactions, which will influence the drug 372 release rate (Kindermann et al, 2011(Kindermann et al, , 2012Quinteros et al, 2011aQuinteros et al, , 2011bGusman et al, 2012).…”

Ocular Delivery of Flurbiprofen Based on Eudragit® E-Flurbiprofen Complex Dispersed in Aqueous Solution: Preparation, Characterization, In Vitro Corneal Penetration, and Ocular Irritation

“…After the remaining basic groups of the polymer were neutralized with 1.0 N HCl, the solvent was evaporated under vacuum at room temperature. In the notation EU–FBH 50 Cl 50 , “50” indicates the percentage of basic groups of EU neutralized by FBH and Cl . Two EU–FBH 50 –Cl 50 aqueous dispersions having 0.1% FB were prepared by adding either dextrose [EU–FBH 50 –Cl 50 (Dex)] or 0.9% NaCl solution [EU–FBH 50 –HCl 50 (NaCl)], respectively.…”

“…In the notation EU-FBH 50 Cl 50 , "50" indicates the percentage of basic groups of EU neutralized by FBH and Cl. 13,19 Two EU-FBH 50 -Cl 50 aqueous dispersions having 0.1% FB were prepared by adding either dextrose [EU-FBH 50 -Cl 50 (Dex)] or 0.9% NaCl solution [EU-FBH 50 -HCl 50 (NaCl)], respectively. A marketed formulation (Tolerane R , 0.1% FB), whose design was based on complexation of FB with $-cyclodextrin ($-CD), [20][21][22] was comparatively assayed.…”

Mechanistic insight into the dramatic improvement of probucol dissolution in neutral solutions by solid dispersion in Eudragit E PO with saccharin

“…The RL, RS and E grades of Eudragit contain amino alkyl side chains as well as carbonyl‐containing methacrylate groups. Therefore, they can interact intermolecularly with acidic drugs and have been investigated as efficient drug carriers [19,20]. We previously reported the use of cryogenic‐grinding to prepare a solid dispersion of the acidic drug, mefenamic acid (MFA), in Eudragit E PO (EPO) [21].…”

“…Therefore, they can interact intermolecularly with acidic drugs and have been investigated as efficient drug carriers. [19,20] We previously reported the use of cryogenic-grinding to prepare a solid dispersion of the acidic drug, mefenamic acid (MFA), in Eudragit E PO (EPO). [21] This solid dispersion had quite high stability in the solid state, and MFA remained in an amorphous state for over 10 months at 25°C and 75% relative humidity (RH).…”