Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience

Kang, Chun; Shi, Junxin; Gong, Yusha; Wei, Jishan; Zhang, Minli; Ding, Huisi; Wang, Kaiqiao; Yu, Yizhen; Wang, Sichao; Han, Juan

doi:10.1016/j.jad.2020.01.051

Cited by 18 publications

(10 citation statements)

References 51 publications

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“…But the prediction of tenacity and strength were not significant. Consistent with previous studies that focused on the role of resilience in emotion (Hou J. et al, 2020;Kang et al, 2020;Ran et al, 2020;Wang J. et al, 2020), this study provided further evidence that optimism was an important resource and could mitigate the negative impact of public health emergencies and stress on individual emotion. A possible explanation was that the optimism dimension of resilience emphasized a positive attitude in adverse situations (Hou J. et al, 2020).…”

Section: Discussionsupporting

confidence: 88%

Resilience Predicts the Trajectories of College Students’ Daily Emotions During COVID-19: A Latent Growth Mixture Model

et al. 2021

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The objective of this study was to examine the association between resilience and trajectories of college students’ negative and positive affect during the COVID-19 pandemic. A total of 391 college students recruited from China completed a daily online negative and positive affect scale for 1 week, and their resilience was also measured. Profiles of brief trajectories of negative and positive affect over time were identified using the latent growth mixture model, and the effect of resilience on these trajectories was further explored. Two latent profiles of negative affect were found: a constant high negative affect profile and a slowly decreasing low negative affect profile, while three latent profiles of positive affect were identified: a slowly increasing high positive affect profile, a rapidly decreasing medium positive affect profile, and a constant medium positive affect profile. The optimism dimension of resilience predicted the membership in the various profiles significantly, whereas the prediction of tenacity and strength dimensions of resilience was not significant. Activities that promote resilience, especially optimism, should be included to improve the daily emotions of college students during COVID-19.

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Section: Discussionsupporting

confidence: 88%

Resilience Predicts the Trajectories of College Students’ Daily Emotions During COVID-19: A Latent Growth Mixture Model

et al. 2021

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“…Extending previous evidence, a novel aspect of this study was that the influences of the parenting style of father/mother (reflecting more stable living background) and their interactions with FKBP5 polymorphisms on adolescent depressive symptoms were explored. In contrast, much of the previous literature on the gene-environment interactions at the FKBP5 locus in the context of depressive symptoms mainly focused on adverse or traumatic life events [ 15 , 20 ]. In this study, without adjusting for sociodemographic variables, significant interactions between FKBP5 rs7757037 and the father’s parenting style were first observed in the codominant and dominant model, even correcting for multiple testing.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study showed the heritability of 40% for depression in a young adult cohort [ 19 ], suggesting genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. Previous evidence suggests that the interactions between environmental stressors and FKBP5 rs3800373/ rs9296158/ rs1360780/ rs9470080 were statistically significant in a sample of clinically depressed adolescents [ 13 ], and the interaction effects of childhood physical abuse and FKBP5 rs3800373/ rs1360780/ rs4713916 on depressive symptoms in Chinese adolescents were significant [ 20 ]. There is evidence that DNA methylation of the FKBP5 gene is modified by external environmental factors [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

et al. 2021

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Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.

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“…Considering the FKBP5 gene plays a vital role in regulating the HPA-axis and is implicated in depressive symptoms [38], it seems appropriate to study the effect of the FKBP5 gene in the context of parenting style as an environmental stressor. Extending previous evidence, a novel aspect of this study was that the in uences of parenting style of father/mother (re ecting more stable living background) and their interactions with FKBP5 polymorphisms on adolescent depressive symptoms were explored; while much of the previous literature on the gene-environment interactions at the FKBP5 locus in the context of depressive symptoms mainly focused on adverse or traumatic life events [15,36]. In this study, without adjusting for sociodemographic variables, signi cant interactions between FKBP5 rs7757037 and the father's parenting style were rst observed in the codominant and dominant model, even correcting for multiple testing.…”

Section: Discussionmentioning

confidence: 99%

“…The inconsistency of these ndings might be explained by methodological variations, modulating environmental stressors, and the epigenetic mechanism. For instance, previous evidence suggests that the interactions between environmental stressors and FKBP5 rs3800373/ rs9296158/ rs1360780/ rs9470080 were statistically signi cant in a sample of clinically depressed adolescents [14], and the interaction effects of childhood physical abuse and FKBP5 rs3800373/ rs1360780/ rs4713916 on depressive symptoms in Chinese adolescents were signi cant [15].…”

Section: Backgroudmentioning

confidence: 99%

Associations of FKBP5 Polymorphisms and Methylation and Parenting Style With Depressive Symptoms Among Chinese Adolescents

Guo

Wang

Guo

et al. 2021

Preprint

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Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.37, 95% CI = 1.07–5.28) and dominant model (AA + AG vs. GG; AOR = 2.22, 95% CI = 1.05–4.69); rs2817032 polymorphism was associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.037) and dominant model (P = 0.038), but the gene-environment interactions were not significant after correcting for multiple testing. The main and interactive effects of FKBP5 methylation status on depressive symptoms were not observed, and no significant mediations were found in the association between FKBP5 polymorphisms and depressive symptoms through the methylation mechanism. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.

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Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience

Cited by 18 publications

References 51 publications

Resilience Predicts the Trajectories of College Students’ Daily Emotions During COVID-19: A Latent Growth Mixture Model

Resilience Predicts the Trajectories of College Students’ Daily Emotions During COVID-19: A Latent Growth Mixture Model

Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Associations of FKBP5 Polymorphisms and Methylation and Parenting Style With Depressive Symptoms Among Chinese Adolescents

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