Interaction between <i>glutathione S‐transferase</i> variants, maternal smoking and childhood wheezing changes with age

Wu, Jiakai; Hankinson, Jenny; Kopec-Harding, Kamilla; Čustović, Adnan; Simpson, Angela

doi:10.1111/pai.12086

Cited by 18 publications

(11 citation statements)

References 28 publications

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“…To the best of our knowledge, few publications have investigated the overall effects of GST variants and ETS exposure on asthma symptoms [ 51 – 55 ], and whether such effects could be modulated by dietary antioxidant intake has not yet been explored. This was the first study to assess how ETS, low dietary vitamin A intake, and GSTP1 genotype affect asthma symptoms in children.…”

Section: Discussionmentioning

confidence: 99%

Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism : a cross -sectional study

et al. 2015

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BackgroundAsthma is characterized by airway inflammation, and bronchial airways are particularly susceptible to oxidant-induced tissue damage.ObjectiveTo investigate the effect of dietary antioxidant intake and environmental tobacco smoke (ETS) on the risk of childhood asthma according to genotypes susceptible to airway diseases.MethodsThis cross-sectional study included 1124 elementary school children aged 7–12 years old. Asthma symptoms and smoking history were measured using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Intake of vitamin A (including retinol and β-carotene), C, and E was measured by a semi-quantitative food frequency questionnaire (FFQ). GSTP1 polymorphisms were genotyped from peripheral blood samples.ResultsETS was significantly associated with presence of asthma symptoms (adjusted odds ratio [aOR], 2.48; 95 % confidence interval [CI], 1.29–4.76) and diagnosis (aOR, 1.91; 95 % CI, 1.19–3.06). Dietary antioxidant intake was not associated with asthma symptoms, although ETS plus low vitamin A intake showed a significant positive association with asthma diagnosis (aOR, 2.23; 95 % CI, 1.10–4.54). Children with AA at nucleotide 1695 in GSTP1 who had been exposed to ETS and a low vitamin A intake have an increased risk of asthma diagnosis (aOR, 4.44; 95 % CI,1.58–12.52) compared with children who had not been exposed to the two risk factors. However, ETS exposure and low vitamin A intake did not significantly increase odds of asthma diagnosis in children with AG or GG genotypes.ConclusionLow vitamin A intake and ETS exposure may increase oxidative stress and thereby risk for childhood asthma. These relationships may be modified by gene susceptibility alleles of GSTP1.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-015-0093-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism : a cross -sectional study

et al. 2015

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“…Childhood-onset asthma risk has been shown to differ by GSTM1 genotype in relation to both maternal smoking in pregnancy (55,56) and childhood ETS exposure (57), with effects largely restricted to children with GSTM1 null genotype. Results from other studies have suggested an interaction between GSTP1 rs1695 A (Ile105) is a risk allele for childhood wheeze illness in relation to maternal smoking in early life, with an effect most clearly seen in children who are exposed to maternal smoking (59,60). Most of the studies looking at interactions with GSTM1 and GSTP1 genetic variants have shown a positive finding, but not always in the same direction for GSTP1 (58).…”

Section: Tobacco Smoking Exposurementioning

confidence: 99%

Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma

Morales

Duffy

2019

Front. Pediatr.

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Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset and adult-onset asthma as different entities, each with a different pathophysiology, trajectory, and outcome. This review provides an overview about the role of genetics and gene-environment interactions in these two conditions. Looking at the genetic overlap between childhood and adult onset disease gives one window into whether there is a correlation, as well as to mechanism. A second window is offered by the genetics of the relationship between each type of asthma and other phenotypes e.g., obesity, chronic obstructive pulmonary disease (COPD), atopy, vitamin D levels, and inflammatory and immune status; and third, the genetic-specific responses to the many environmental exposures that influence risk throughout life, and particularly those that occur during early-life development. These represent a large number of possible combinations of genetic and environmental factors, at least 150 known genetic loci vs. tobacco smoke, outdoor air pollutants, indoor exposures, farming environment, and microbial exposures. Considering time of asthma onset extends the two-dimensional problem of gene-environment interactions to a three-dimensional problem, since identified gene-environment interactions seldom replicate for childhood and adult asthma, which suggests that asthma susceptibility to environmental exposures may biologically differ from early life to adulthood as a result of different pathways and mechanisms of the disease.

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“…G (Gene) x ETS interaction underlying susceptibility to asthma and asthma-related phenotypes have been first evidenced in the context of genome-wide linkage scans [5][6][7] and by association studies with candidate genes including ADRB2 (β2-adrenergic receptor) [8], GSTM1 (Glutathione S-Transferase M1) [9], GSTT1 (Glutathione S-Transferase T1) [9] and GSTP1 (Glutathione S-Transferase P1) [10]. Genetic variants at the 17q21 locus that were detected by a GWAS of childhood asthma [11] were shown to confer an increased risk of early-onset asthma in subjects exposed to early-life ETS first in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) study [12] and, subsequently, in other studies [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Interaction between theDNAH9gene and early smoke exposure in bronchial hyperresponsiveness

et al. 2016

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A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a gene×early-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was to conduct fine-scale mapping of 17p11 to identify single nucleotide polymorphisms (SNPs) interacting with ETS that influence BHR.Analyses were performed in 388 French EGEA asthmatic families, using a two-step strategy: 1) selection of SNPs displaying family-based association test (FBAT) association signals (p≤0.01) with BHR in unexposed siblings, and 2) a FBAT homogeneity test between exposed and unexposed siblings plus a robust log-linear interaction test.A single SNP reached the threshold (p≤3×10−3) for significant interaction with ETS using both interaction tests, after accounting for multiple testing. Results were replicated in 253 French-Canadian families, but not in 341 UK families, probably due in part to differences in phenotypic features between datasets.The SNP showing significant interaction with ETS belongs to DNAH9 (dynein, axonemal, heavy chain 9), a promising candidate gene involved in respiratory cilia mobility and associated with primary ciliary dyskinesia, a disease associated with abnormalities of pulmonary function.

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Interaction between glutathione S‐transferase variants, maternal smoking and childhood wheezing changes with age

Abstract: Children with AA genotype for GSTP1 are at increased risk of early-life wheezing if their mothers smoke, but the effect of maternal smoking on wheezing diminishes with time.

Cited by 18 publications

References 28 publications

Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism : a cross -sectional study

Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism : a cross -sectional study

Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma

Interaction between theDNAH9gene and early smoke exposure in bronchial hyperresponsiveness

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