Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

Sasaki, Seiko; Limpar, Mariko; Sata, Fumihiro; Kobayashi, Sumitaka; Kishi, Reiko

doi:10.1038/pr.2017.70

Cited by 34 publications

(43 citation statements)

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“…Coffee drinking is beneficial when we drink in moderation 2-4 cup per day it has a negative effect on our health when we drink more than considerable range [1]. Also, Nonsmokers who rapidly metabolize caffeine may be at increased risk for having infants with decreased birth size when consuming ≥ 300 mg of caffeine per day [74].…”

Section: Health Risks Of Coffee Consumptionmentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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Coffee is the world's beloved drink that is the most regularly consumed caffeine-containing beverage next to water and tea. It contains a multipart combination of chemicals constituents, which associated with health benefits, most consumers, begin their day with a minimum a cup of coffee after eating food, and end their workday with coffee. It is considered as a significant part of modern daily life because it has an alerting outcome on the human brain. Opposing this, various groups report experiencing uneven health risks thus hesitant to drink coffee, this suggests individual disparity to coffee intolerance. The aim of this review was to in brief summarize health benefits and risks coffee consumption. Most of the informative reports suggested that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among these it is used to boosts our physical performance, burn fat, reduces risk of stroke, liver, prostate and colorectal cancer by 20%, risk of Parkinson's disease by 25%, lower risk of Type II diabetes, reduces risk of dementia and protects our mind, brightens our mood, helps us to fight depression and minimize risk of suicide by 50%. In addition, coffee consumers have less risk of heart disease, with strongly integrated DNA. Also reports that coffee drinking has also naturally extended sleep latency, minimizes total sleep time and its effectiveness, and worsened supposed sleep feature.However, from positive health prospect of coffee consumption, a recent study finds coffee consumption does not always provide protective benefits because overdrinking is associated with negative impact or risk on our health. Some negative impact of coffee consumption on our health; it reduces appetite levels for food, impact on pregnant women, on people with cholesterol, cause insomnia and restlessness, breast tissue cysts in women, incontinence digestive disorders, and risk of headaches. In addition, decrease fertility probability in female and male, cause allergies and miscarriage, forceful heart contractions, anxiety, depression and the need for anxiety medication, inhibits collagen production in the skin of human being, less hearing loss improvement, does not help with extended sleep deprivation interferes with ossification and could also lead to greater risk of bone fracture. Finally, the most recent studies reported that coffee consumption is beneficial for our health when it is optimum range approximately four cups on average. The supplementary research will be crucial to make clear that both the health benefits and risk of coffee consumption.

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Section: Health Risks Of Coffee Consumptionmentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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“…Nehlig Japanese study (Sasaki et al, 2017). This association might help understanding the inconsistent effects observed on the fetus after caffeine consumption.…”

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confidence: 95%

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption

2018

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Most individuals adjust their caffeine intake according to the objective and subjective effects induced by the methylxanthine. However, to reach the desired effects, the quantity of caffeine consumed varies largely among individuals. It has been known for decades that the metabolism, clearance, and pharmacokinetics of caffeine is affected by many factors such as age, sex and hormones, liver disease, obesity, smoking, and diet. Caffeine also interacts with many medications. All these factors will be reviewed in the present document and discussed in light of the most recent data concerning the genetic variability affecting caffeine levels and effects at the pharmacokinetic and pharmacodynamic levels that both critically drive the level of caffeine consumption. The pharmacokinetics of caffeine are highly variable among individuals due to a polymorphism at the level of the CYP1A2 isoform of cytochrome P450, which metabolizes 95% of the caffeine ingested. Moreover there is a polymorphism at the level of another critical enzyme, -acetyltransferase 2. At the pharmacodynamic level, there are several polymorphisms at the main brain target of caffeine, the adenosine A2A receptor or ADORA2. Genetic studies, including genome-wide association studies, identified several loci critically involved in caffeine consumption and its consequences on sleep, anxiety, and potentially in neurodegenerative and psychiatric diseases. We start reaching a better picture on how a multiplicity of biologic mechanisms seems to drive the levels of caffeine consumption, although much more knowledge is still required to understand caffeine consumption and effects on body functions.

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“…Notably, caffeine's effects on pregnancy outcomes have been shown to be highly variable between individuals in both rodents [35,38] and humans [5,8,9,45,46] (Figure 2A). Substantial interindividual phenotypic variation and the underling mechanism(s) in complex traits and diseases have become an area of significant scientific interest over the past two decades.…”

Section: Interindividual Variation In Caffeine Responsementioning

confidence: 99%

“…in caffeine metabolism, represents a well-studied example ( Figure 2B and Box 1). Epidemiological studies have found that when exposed to the same dosages of caffeine, women with higher CYP1A2 enzyme activity (rapid caffeine metabolism) have an increased risk of pregnancy disorders compared to those with lower CYP1A2 enzyme activity [5,8,9,45,46]. Human CYP1A2 mRNA levels represent more than 40-fold interindividual differences, and the in vivo activity of the CYP1A2 enzyme varies up to 60-fold, as probed by the 3-demethylation of caffeine [49].…”

Section: Interindividual Variation In Caffeine Responsementioning

confidence: 99%

“…Postulated models underpinning the highly variable individual response to caffeine exposure. (A) Women showed different responses to caffeine exposure during pregnancy[5,8,9,45,46]. (B) The effects of caffeine might be regulated by multiple factors in vivo, including the ability to metabolize caffeine (determined by the ratelimiting enzyme CYP1A2) and cellular targets (mainly through ADORA1/A2A), or regulated through modulators associated with pregnancy and fetal development, all of which modify the outcome of pregnancy for individual women after caffeine exposure.…”

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confidence: 99%

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