Interaction between Neurotensin and Dopamine in the Brain

Potentiatin by Neurotensin of Carbachol-Induced Tension Development in .BETA.-Escin-Skinned Smooth Muscle of Guinea-Pig Ileum.

“…In the brain, NT acts as a neuromodulator, particularly on dopaminergic transmission [15,30]. It also exerts hypothermic and analgetic effects [2,3].…”

“…The muscle strip Neurotensin (NT), a tridecapeptide, is one of the gutbrain regulatory peptides, and is widely distributed in the central nervous system and the gastrointestinal tract [6,7]. In the brain, NT acts as a neuromodulator, particularly on dopaminergic transmission [15,30]. It also exerts hypothermic and analgetic effects [2,3].…”

Antagonism by SR 48692 of mechanical responses to neurotensin in rat intestine

“…NT, has a broad spectrum of biological activities. In the brain, NT displays neuromodulator actions, in particular on dopaminergic transmission in the nigro-striatal and meso-cortico-limbic system, and it exerts potent hypothermic and analgesic effects when injected in the central nervous system (Bissette et al, 1976;Kasckow & Nemeroff, 1991;Behbehani, 1992;Rostene et al, 1992). In the periphery, when injected intravenously, NT produces several cardiovascular effects, including hypotension and increased vascular permeability, attributable to its ability to stimulate secretion from mast cells (Cochrane, 1990;Prange, 1992).…”

Neurotensin as Modulator of Basal Ganglia- Thalamocortical Motor Circuit – Emerging Evidence for Neurotensin NTS1 Receptor as a Potential Target in Parkinson's Disease

“…Finally, in the globus pallidus, neurotensin receptors (NTS 1 and NTS 2 ) exist in different neurons and are located both pre-synaptically and post-synaptically (Fassio et al, 2000;Sarret et al, 2003) thus regulating (mainly NTS 1 receptors), both pallidal glutamatergic and GABAergic transmission (Chen et al, 2004;. Such distribution of NTS 1 receptors justifies the modulation that neurotensin exerts on the mesolimbic, mesocortical and nigrostriatal dopamine neurons, as well as on glutamatergic and GABAergic neurones (Deutch and Zahm, 1992;Fuxe et al, 1992 a,b;Rostene et al, 1992;Binder et al, 2001;Dobner et al, 2003;Petrie et al, 2005). Most of the central and peripheral functions controlled by NTS 1 receptors have been elucidated by the use of the non-peptide neurotensin antagonist SR48692, which preferentially binds NTS 1 receptors (Gully et al, 1993;Rostene et al, 1997).…”

“…In particular, the influence of neurotensin on nigrostriatal and mesocorticolimbic dopaminergic systems suggests that neurotensin may play a relevant role in dopamine-associated pathologies, such as some neurodegenerative disorders and neuropsychiatric diseases (Rostene et al, 1992;Lambert et al, 1995;StGelais et al, 2006). I n t h e f o l l o w i n g p a r t o f t h i s s e c t i o n , d a ta obtained from human and animal studies providing the existence of relationships between neurotensin and neurodegenerative disorders, will be shortly summarized.…”