Interaction between periodontitis and liver diseases

Han, Pengyu; Sun, Dongdong; Yang, Ju Hye

doi:10.3892/br.2016.718

Cited by 60 publications

(64 citation statements)

References 148 publications

(128 reference statements)

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“…In the current literature, the association between periodontal disease and liver injury has been lately reported . Several papers have demonstrated that the presence of hepatic inflammation after ligature induced periodontitis around molars .…”

Section: Discussionmentioning

confidence: 99%

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Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Meşter

Ciobanu

Taulescu

et al. 2019

Journal of Periodontology

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Background The aim was to assess the effects of periodontal disease in promoting liver fibrosis in a rat model of ligature‐induced periodontitis. Methods Twenty‐four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), at day 14 (PER14), at day 21 (PER21). Experimental periodontitis was induced by the placement of a silk ligature around mandibular incisors. The following parameters were assessed: gingival index, tooth mobility; liver status, and portal vein caliber by ultrasound examination; bone retraction, bone mineral density (BMD), bone volume/tissue volume (BV/TV) by micro‐CT analysis; aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT); oxidative stress (malondialdehyde [MDA], reduced glutathione/oxidative glutathione ratio [GSH/GSSG]), and matrix metalloproteinase‐8 (MMP‐8) levels; and histopathological evaluation of periodontal and liver tissues. Results Periodontal parameters showed the development of periodontitis in experimental groups. Micro‐CT results indicates an increase of bone retraction and BMD values and a decrease of BV/TV value in PER groups. Liver fibrosis could not be diagnosed with ultrasound examination in any of the groups. Elevated levels of ASAT and ALAT in PER groups compared with CTRL group were found. MDA have indicated elevated levels and a decrease of GSH/GSSG ratio in PER group compared with the CTRL group. Levels of MMP‐8 have indicated high values in PER21 compared with the other groups. Histological analysis of the periodontal and liver tissues sustains the link between periodontal and hepatic injury. Conclusion This study demonstrates a positive correlation between periodontal lesions and liver disease. Periodontitis may be an independent risk factor for liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

“…The link between periodontal disease and liver injury has been mentioned in the review of Han et al . Periodontal structures produce inflammatory cytokines and periodontal bacteria, which are translocated via bloodstream to the liver.…”

Section: Discussionmentioning

confidence: 99%

Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Meşter

Ciobanu

Taulescu

et al. 2019

Journal of Periodontology

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“…Epidemiological studies have found associations between periodontitis and systemic disease, including cardiovascular disease, kidney disease, obesity and adverse pregnancy outcomes . Emerging evidence also suggests a link to liver disease …”

Section: Introductionmentioning

confidence: 99%

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Helenius‐Hietala

Suominen

Ruokonen

et al. 2018

Liver International

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Background & Aims Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors may benefit subjects at risk. Few studies have analyzed periodontitis as a risk factor for liver complications. We studied whether periodontitis is associated with incident severe liver disease. Methods The study comprised 6165 individuals without baseline liver disease who participated in the Finnish population‐based Health 2000 Survey (BRIF8901) during 2000‐2001, a nationally representative cohort. Follow‐up was until 2013 for liver‐related admissions, liver cancer and mortality from National Hospital Discharge, Finnish Cancer Registry and Causes of Death Register, Statistics Finland. Mild to moderate periodontitis was defined as ≥1 tooth with periodontal pocket ≥4 mm deep, and advanced periodontitis as ≥5 teeth with such pockets. Multiple confounders were considered. Results A total of 79 subjects experienced a severe liver event during follow‐up. When adjusted for age, sex and number of teeth, hazards ratios by Cox regression regarding incident severe liver disease were, for mild to moderate periodontitis, 2.12 (95% CI 0.98‐4.58), and, for advanced periodontitis, 3.69 (95% CI 1.79‐7.60). These risk estimates remained stable after additionally adjusting for alcohol use, smoking, metabolic risk, serum gamma‐glutamyltransferase, dental‐care habits, lifestyle and socioeconomic status. Periodontal disease‐associated liver risk was accentuated among subjects with non‐alcoholic fatty liver disease or heavy alcohol use at baseline. Conclusions Periodontitis was associated with incident liver disease in the general population independently of various confounders. As a preventable disease, periodontal disease might present a modifiable risk factor for chronic liver disease.

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“…It is routine clinical practice to treat periodontitis prior to liver transplant in order to eliminate all potential infectious foci and reduce the risk of postsurgical complications (76). In addition to potentially affecting transplant outcomes, periodontitis is associated clinically with liver diseases such as precirrhotic NAFLD, cirrhosis, and hepatocellular carcinoma (77). While the studies are still limited and a link between periodontal and liver diseases is not as well established as associations between periodontitis and other systemic conditions, such as diabetes and cardiovascular disease (78), it is likely that similar factors related to the oral microbiota and inflammation connect oral and liver disease, as well.…”

Section: Ahluwalia Et Al 2016 (56)mentioning

confidence: 99%