Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people

Colovati, Mileny Esbravatti Stephano; Novais, Iane de Paiva; Zampol, M.; Mendes, Gustavo Duarte; Cernach, Mirlene Cecília Soares Pinho; Zanesco, Angelina

doi:10.1590/1414-431x202010098

Cited by 11 publications

(9 citation statements)

References 55 publications

(62 reference statements)

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“…Importantly, the epigenetic regulation of gene expression mediated by histone deacetylases (HDACs), which act by removing acetyl groups from histones, resulting in gene silencing, has been demonstrated to play a substantial role in AD pathophysiology. , HDACs are critically involved in the regulation of the expression of genes involved in lipid metabolism and long-term potentiation, and HDAC inhibitors (HDACi’s) represent a promising therapeutic approach against AD . In this regard, pan class I HDACi’s were recently indicated to increase astrocytic APOE expression and secretion .…”

Section: Apolipoprotein E: Structure Isoforms Normal Function and Dis...mentioning

confidence: 99%

“…A higher physical exercise level has been associated with improved cognitive function in healthy individuals . A systematic review indicated that physical exercise reduced the risk of AD by ∼50% .…”

Section: Apoe and Ad: Potential Gene–environment Interactionsmentioning

confidence: 99%

“…It has been shown that compared with APOE4 noncarriers, APOE4 carriers are more susceptible to the beneficial impact of physical exercise on cognition. , Physically active APOE4 carriers displayed less cognitive decline and hippocampal atrophy compared with APOE4 carriers who were physically inactive, suggesting that greater physical activity may protect against AD-related neurodegeneration in APOE4 carriers . Long-term physical activity that is initiated during middle life has been associated with reduced amyloid-beta burden, in particular, in APOE4 carriers .…”

Section: Apoe and Ad: Potential Gene–environment Interactionsmentioning

confidence: 99%

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APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors

Angelopoulou

Paudel

Papageorgiou

et al. 2021

ACS Chem. Neurosci.

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder with obscure pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that develops from the complex interplay of genetic factors and environmental exposures. The E4 allele of the gene encoding apolipoprotein E (APOE) is the most common genetic risk factor for AD, whereas the E2 allele acts in a protective manner. A growing amount of epidemiological evidence suggests that several lifestyle habits and environmental factors may interact with APOE alleles to synergistically affect the risk of AD development. Among them, physical exercise, dietary habits including fat intake and ketogenic diet, higher education, traumatic brain injury, cigarette smoking, coffee consumption, alcohol intake, and exposure to pesticides and sunlight have gained increasing attention. Although the current evidence is inconsistent, it seems that younger APOE4 carriers in preclinical stages may benefit mostly from preventive lifestyle interventions, whereas older APOE4 noncarriers with dementia may show the most pronounced effects. The large discrepancies between the epidemiological studies may be attributed to differences in the sample sizes, the demographic characteristics of the participants, including age and sex, the methodological design, and potential related exposures and comorbidities as possible cofounding factors. In this Review, we aim to discuss available evidence of the prominent APOE genotype–environment interactions in regard to cognitive decline with a focus on AD, providing an overview of the current landscape in this field and suggesting future directions.

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Section: Apolipoprotein E: Structure Isoforms Normal Function and Dis...mentioning

confidence: 99%

Section: Apoe and Ad: Potential Gene–environment Interactionsmentioning

confidence: 99%

Section: Apoe and Ad: Potential Gene–environment Interactionsmentioning

confidence: 99%

See 1 more Smart Citation

APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors

Angelopoulou

Paudel

Papageorgiou

et al. 2021

ACS Chem. Neurosci.

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“…Physical exercise has been described as a protective factor against cognitive decline and AD. The effects of physical exercise can be modulated by genetic factors, as suggested in AD patients, where APOE4 allele carriers were more responsive to the beneficial effects of physical activity compared to non-carriers [ 84 ].…”

Section: Physical Activity and Nddsmentioning

confidence: 99%

Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

Barati

Fabrizio

Strafella

et al. 2022

Genes

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In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact of genetic and epigenetic factors, nutrients, and lifestyle will be presented, with particular emphasis on Alzheimer’s disease (AD) and Parkinson’s disease (PD). Metabolism, dietary habits, physical exercise and microbiota are part of a complex network that is crucial for brain function and preservation. This complex equilibrium can be disrupted by genetic, epigenetic, and environmental factors causing perturbations in central nervous system homeostasis, contributing thereby to neuroinflammation and neurodegeneration. Diet and physical activity can directly act on epigenetic modifications, which, in turn, alter the expression of specific genes involved in NDDs onset and progression. On this subject, the introduction of nutrigenomics shed light on the main molecular players involved in the modulation of health and disease status. In particular, the review presents data concerning the impact of ADH1B, CYP1A2, and MTHFR on the susceptibility and progression of NDDs (especially AD and PD) and how they may be exploited for developing precision medicine strategies for the disease treatment and management.

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“…Regular physical activity also improved executive function, working memory, and cognitive flexibility [19]. However, such advantages of physical activity on cognition in people with AD were not universal across studies (reviewed in [20]), probably owing to heterogeneous samples and methodologies, and the lack of standardized protocols.…”

Section: Physical Activitymentioning

confidence: 99%

Personalized treatment interventions: nonpharmacological and natural treatment strategies in Alzheimer’s disease

Šagud

Tudor

Pivac

2021

Expert Review of Neurotherapeutics

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Introduction: Alzheimer's disease (AD) is a slow, irreversible, progressive, complex, and fatal neurodegenerative disorder. Available pharmacological treatment, known for almost two decades, does not cure the disease, but only alleviates the symptoms, with various efficacy and different side effects. Therefore, there is an unmet need to find other person-centered or personalized approaches to treat AD. Areas covered: This article describes the application of precision medicine-like approaches utilizing nonpharmacological treatment strategies and the use of natural products in personalized care for patients with AD. Expert opinion: Due to the heterogeneity of disease symptoms, somatic conditions, and patient preferences, there is definitely no "one size fits all" intervention. Therefore, individualized treatment choice is based on dementia stage, medical and psychiatric comorbidity, leading symptoms, patient preferences, and remaining capacity of the patient. In the absence of disease-modifying agents, a patient-centered, multidisciplinary team approach appears to be the best option to alleviate the heavy symptomatic burden in this unfortunate population. Hence, appropriate interventions can be offered along the AD continuum, while a better understanding of personal characteristics might help in establishing optimal individualized treatment, as well as its duration and intensity, to deliver interventions in the most effective ways.

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Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people

Cited by 11 publications

References 55 publications

APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors

APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors

Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

Personalized treatment interventions: nonpharmacological and natural treatment strategies in Alzheimer’s disease

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