Interaction between phytotherapy and oral anticancer agents: prospective study and literature review

Clairet, Anne-Laure; Boiteux-Jurain, M.; Curtit, Elsa; Jeannin, Marie; Gérard, B.; Nerich, Virginie; Limat, Samuel

doi:10.1007/s12032-019-1267-z

Cited by 52 publications

(40 citation statements)

References 297 publications

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“…These interactions were often highlighted by the pharmacist, as a majority of patients did not declare this practice to their hematologist/oncologist. 14 Clinical impact of interactions between phytotherapy and conventional medicines was hard to translate because of a lack of data in the literature. We thus decided to classify them as a moderate clinical impact, meaning that the PI could prevent further monitoring or treatment without leading to a hospital stay for the patient.…”

Section: Discussionmentioning

confidence: 99%

Clinical and economic impact of pharmacist interventions in an ambulatory hematology–oncology department

Grégori

Pistre

Boutet

et al. 2020

J Oncol Pharm Pract

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Objectives To evaluate clinical and financial impact of pharmacist interventions in an ambulatory adult hematology–oncology department. Methods All cancer patients receiving a first injectable immuno- and/or chemotherapy regimen were included in this prospective study over a one-year period. The clinical impact of pharmacist interventions made by two clinical pharmacists was rated using the Clinical Economic and Organizational tool. Financial impact was calculated through cost savings and cost avoidance. Main results: Five hundred and fifty-eight patients were included. A total of 1970 pharmacist interventions were performed corresponding to a mean number of 3.5 pharmacist interventions/patient. The clinical impact of pharmacist interventions was classified as negative, null, minor, moderate, major and lethal in 0, 84 (4%), 1353 (68%), 385 (20%), 148 (8%) and 0 cases, respectively. The overall cost savings were €175,563. One hundred and nine (6%) of all pharmacist interventions concerned immuno- or chemotherapy regimen for cost savings of €148,032 (84% of the total amount of cost savings). The cost avoidance was €390,480. Cost avoidance results were robust to sensitivity analyses with cost of preventable adverse drug event as main driver of the model. When the cost of employing a pharmacist was subtracted from the average yearly cost savings plus cost avoidance per pharmacist, this yielded a net benefit of €223,021. The cost–benefit ratio of the clinical pharmacist was €3.7 for every €1 invested. Principal conclusions: To have two full-time clinical pharmacists in a 55-bed ambulatory adult hematology–oncology department is both clinically and financially beneficial.

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Section: Discussionmentioning

confidence: 99%

Clinical and economic impact of pharmacist interventions in an ambulatory hematology–oncology department

Grégori

Pistre

Boutet

et al. 2020

J Oncol Pharm Pract

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“…[ 12 ] However, in a recent survey of 1,016 hematology/oncology patients, Hierl et al reported that a large majority of people were in favor of their oncologist being informed about their CTs. [ 13 ] Numerous studies have been published on specific associations, such as the pharmacokinetic interactions between plants and over-the-counter drugs with oral anticancer agents, [ 14 ] interactions between mistletoe extracts and adjuvant chemotherapy prescribed for breast cancer patients [ 15 ] and interactions between herbal medicine and chemotherapy in patients with ovarian cancer. [ 16 ]…”

Section: Discussionmentioning

confidence: 99%

Knowledge and use of complementary therapies in a tertiary care hospital in France

et al. 2020

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“…In the United States, during 2007, the most common types of CAM utilized by the US residents were natural products (17.7%) and deep breathing exercises (12.7%) [2]. e results of this study, together with the studies above, indicate the cruciality of asking patients about the use of herbal products to avoid any therapy failure due to drugherb interactions, which have been frequently documented in the literature [62][63][64][65][66][67][68][69][70][71][72][73]. Moreover, with almost 18% of subjects using CAM because of their beliefs about its usefulness ( Figure 4) which may not be substantiated by scientific evidence, patients may abandon their prescribed medications and continue using CAM, leading to worsening of their disease status.…”

Section: Discussionmentioning

confidence: 69%

The Utilization of Complementary and Alternative Medicine among Saudi Older Adults: A Population‐Based Study

Aljawadi

Khoja

Alotaibi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Complementary and alternative medicine (CAM) is an integral part of patients' therapeutic experience worldwide. Among Saudi older adults, less is known about CAM utilization. Objectives. To determine the prevalence, patterns, and factors associated with CAM utilization among SOA. Methods. In the Saudi National Survey for Elderly Health (SNSEH), subjects were asked about CAM use during the last twelve months before the interview. CAM use was defined as any use of herbal products, acupuncture, bloodletting, cauterization, medical massage, bones manual manipulation, honey, or religious rituals. Demographic characteristics included gender, age, marital status, region, educational level, and residence area. In addition, multiple comorbidities were included as possible factors that may be associated with CAM use. Multivariable logistic regression was used to explore factors associated with CAM utilization. All statistical analyses were done using STATA v.14. Results. Out of 2946 respondents, 50.4% were males, the mean age was 70.3 ± 8.3 years, and 70% were illiterate. CAM use was prevalent (62.5%). The most common CAM types were herbal products (25.4%), acupuncture (21.2%), bloodletting (12%), honey (9.5%), cauterization (7.4%), medical massage and bones manual manipulation (4%), and traditional bone setting (2.1%). In the multivariable regression, age, gender, and marital status did not have an impact on the odds of using CAM. Subjects from rural areas were 2.92 times more likely to use CAM compared with subjects in urban areas (OR = 2.92; 95%CI: 2.28‐3.75). Subjects with metabolic disorders (OR = 0.50; 95% CI: 0.42‐0.60) or kidney disease were less likely to use CAM (OR = 0.30; 95%CI: 0.14‐0.64). About pain, CAM is used more in neck pain (OR = 1.69; 95%CI: 1.30‐2.21) and also used in back pain (OR = 1.22; 95%CI: 1.03‐1.46). Conclusions. CAM use was very prevalent among SOA. Clinicians and pharmacists must ask about CAM use among older adults as many of CAM may interact with patients medications.

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Interaction between phytotherapy and oral anticancer agents: prospective study and literature review

Cited by 52 publications

References 297 publications

Clinical and economic impact of pharmacist interventions in an ambulatory hematology–oncology department

Clinical and economic impact of pharmacist interventions in an ambulatory hematology–oncology department

Knowledge and use of complementary therapies in a tertiary care hospital in France

The Utilization of Complementary and Alternative Medicine among Saudi Older Adults: A Population‐Based Study

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