Interaction Between Recovery of Motor and Language Abilities After Stroke

Ginex, Valeria; Gilardone, Giulia; Viganò, Mauro; Monti, Alessia; Judica, Elda; Passaro, Ilaria; Gilardone, Marco; Vanacore, Nicola; Corbo, Massimo

doi:10.1016/j.apmr.2020.04.010

Cited by 10 publications

(11 citation statements)

References 29 publications

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“…Previous studies have mentioned that the recovery of motor and language function is operated in parallel [20][21][22][23]. Due to the lack of data demonstrating UE motor status associated with language function, current stroke rehabilitation evaluations and therapies have treated these two symptoms separately [8,24]. Patients with PSA receiving speech-language therapy are frequently seated during treatment, with UE impassive and motionless [9].…”

Section: Discussionmentioning

confidence: 99%

“…These phenomena suggest a deep neural mechanism relationship between language function and UE motor status after stroke. Several studies [8][9][10][11] have focused on the potential relationship between UE motor status and language function. From a human evolution perspective, language was spurred by freedom of hand movement as an additional consequence of this upright posture.…”

Section: Introductionmentioning

confidence: 99%

“…A retrospective cohort study addressed the possible interaction between motor impairment and aphasia recovery after stroke. Motor responders showed better linguistic performances at the final aphasia assessment than motor nonresponders, while language responders reached a higher level of motor functioning than language nonresponders [ 8 ]. Meanwhile, a significant response in one domain was not associated with any deterioration in the other.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have focused on the difference in UE motor function status between patients with PSA and nonphasic poststroke patients. Moreover, no study provides evidence on the correlation between UE motor status and language function after stroke [ 8 , 9 ], which leads to low attention to UE-language correlation so that UE and speech-language therapies are completely separated during UE motor and (or) speech rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

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Associations between Upper Extremity Motor Function and Aphasia after Stroke: A Multicenter Cross-Sectional Study

Yan

Pan

Yang

et al. 2021

Behavioural Neurology

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Background and Purpose. Poststroke aphasia (PSA) often coexists with upper extremity (UE) motor dysfunction. However, whether the presence of PSA affects UE motor performance, and if language function associates with UE motor performance, are unclear. This study is aimed at (1) comparing the motor status of UE between patients with PSA and without PSA and (2) investigating the association between language function and UE motor status in patients with PSA. Methods. Patients with stroke were compared and correlated from overall and three periods (1-3 months, 4-6 months, and >6 months). Fugl-Meyer assessment for the upper extremity (FMA-UE) and action research and arm test (ARAT) were used to compare the UE motor status between patients with PSA and without PSA through a cross-sectional study among 435 patients. Then, the correlations between the evaluation scale scores of UE motor status and language function of patients with PSA were analyzed in various dimensions, and the language subfunction most closely related to UE motor function was analyzed by multiple linear regression analysis. Results. We found that the scores of FMA-UE and ARAT in patients with PSA were 14 points ((CI) 10 to 18, p < 0.001 ) and 11 points lower ((CI) 8 to 13, p < 0.001 ), respectively, than those without PSA. Their FMA-UE ( r = 0.70 , p < 0.001 ) and ARAT ( r = 0.62 , p < 0.001 ) scores were positively correlated with language function. Regression analysis demonstrated that spontaneous speech ability may account for UE motor function ( R 2 = 0.51 , p < 0.001 ; R 2 = 0.42 , p < 0.001 ). Consistent results were also obtained from the analyses within the three time subgroups. Conclusion. Stroke patients with PSA have worse UE motor performance. UE motor status and language function showed positive correlations, in which spontaneous speech ability significantly accounts for the associations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Associations between Upper Extremity Motor Function and Aphasia after Stroke: A Multicenter Cross-Sectional Study

Yan

Pan

Yang

et al. 2021

Behavioural Neurology

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“…Sixth, data collection was conducted in the chronic stage, mostly in the patients' homes. Possible impact of residual chronic aphasia among LHD patients and residual spatial neglect among RHD patients (Katz et al, 1999;Ginex et al, 2020) could not be assessed on the basis of formal testing at that time (however, patients were excluded if the examiner had the impression that either language or cognitive problems precluded clear understanding of the requirements of the studied tasks). Lastly, despite the fact that in both the LHD and RHD groups, age, followup imaging time, total hemispheric volume loss and the extent of damage in each atlas region did not correlate with either the FMA-LE score or the 3MWT score, it is still possible that VLSM studies analyzing these variables as covariates (such analysis cannot be conducted in the MEDx software we use) will refine the results, as suggested recently by Rajashekar et al (2020).…”

Section: Limitationsmentioning

confidence: 99%

Stroke Lesion Impact on Lower Limb Function

Frenkel‐Toledo

Ofir-Geva

Mansano

et al. 2021

Front. Hum. Neurosci.

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The impact of stroke on motor functioning is analyzed at different levels. ‘Impairment’ denotes the loss of basic characteristics of voluntary movement. ‘Activity limitation’ denotes the loss of normal capacity for independent execution of daily activities. Recovery from impairment is accomplished by ‘restitution’ and recovery from activity limitation is accomplished by the combined effect of ‘restitution’ and ‘compensation.’ We aimed to unravel the long-term effects of variation in lesion topography on motor impairment of the hemiparetic lower limb (HLL), and gait capacity as a measure of related activity limitation. Gait was assessed by the 3 m walk test (3MWT) in 67 first-event chronic stroke patients, at their homes. Enduring impairment of the HLL was assessed by the Fugl–Meyer Lower Extremity (FMA-LE) test. The impact of variation in lesion topography on HLL impairment and on walking was analyzed separately for left and right hemispheric damage (LHD, RHD) by voxel-based lesion-symptom mapping (VLSM). In the LHD group, HLL impairment tended to be affected by damage to the posterior limb of the internal capsule (PLIC). Walking capacity tended to be affected by a larger array of structures: PLIC and corona radiata, external capsule and caudate nucleus. In the RHD group, both HLL impairment and walking capacity were sensitive to damage in a much larger number of brain voxels. HLL impairment was affected by damage to the corona radiata, superior longitudinal fasciculus and insula. Walking was affected by damage to the same areas, plus the internal and external capsules, putamen, thalamus and parts of the perisylvian cortex. In both groups, voxel clusters have been found where damage affected FMA-LE and also 3MWT, along with voxels where damage affected only one of the measures (mainly 3MWT). In stroke, enduring ‘activity limitation’ is affected by damage to a much larger array of brain structures and voxels within specific structures, compared to enduring ‘impairment.’ Differences between the effects of left and right hemisphere damage are likely to reflect variation in motor-network organization and post-stroke re-organization related to hemispheric dominance. Further studies with larger sample size are required for the validation of these results.

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The value of diffusion weighted imaging in predicting the clinical progression of perforator artery cerebral infarction

Yang

Liu

et al. 2022

NeuroImage: Clinical

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Interaction Between Recovery of Motor and Language Abilities After Stroke

Cited by 10 publications

References 29 publications

Associations between Upper Extremity Motor Function and Aphasia after Stroke: A Multicenter Cross-Sectional Study

Associations between Upper Extremity Motor Function and Aphasia after Stroke: A Multicenter Cross-Sectional Study

Stroke Lesion Impact on Lower Limb Function

The value of diffusion weighted imaging in predicting the clinical progression of perforator artery cerebral infarction

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