Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants

Hashizume, Takumi; Shida, Rino; Suzuki, Shinichi; Kasuya, Etsuko; Kuwayama, Hideto; Suzuki, Hiroyuki; Olah, Mark E.; Nagy, György M.

doi:10.1016/j.domaniend.2007.09.002

Cited by 19 publications

(37 citation statements)

References 13 publications

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“…2008a). However, the experiments of Hashizume et al. (2008a,b) were performed on relatively young animals, not during lactation and the concentrations of administered salsolinol, especially into the IIIv, were many times higher than in our study on lactating ewes.…”

Section: Discussioncontrasting

confidence: 70%

“…The prolactin‐releasing effect of salsolinol has been shown earlier in rats, both in females during lactation and in males (Toth et al. 2001), as well as in ruminants (Hashizume et al. 2008a,b).…”

Section: Discussionmentioning

confidence: 90%

“…2001). In ruminants, a stimulating effect of salsolinol on prolactin was found in goats following intravenous injection (Hashizume et al. 2008a,b) and in 5‐month‐old calves after intracerebroventricular administration (Hashizume et al.…”

Section: Discussionmentioning

confidence: 99%

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The Possible Involvement of Salsolinol and Hypothalamic Prolactin in the Central Regulatory Processes in Ewes During Lactation

Górski¹,

Romanowicz²,

Herman

et al. 2009

Reproduction in Domestic Animals

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Salsolinol, a dopamine-related compound and prolactin-producing cells were found in the ovine hypothalamus. This study was designed to test the hypothesis that salsolinol, acting from the CNS level, is able to stimulate pituitary prolactin release as well as prolactin mRNA expression in the anterior pituitary cells (AP) and in the mediobasal hypothalamus (MBH) in lactating ewes. The intracerebroventricular infusions of salsolinol in two doses, total of 50 ng or 5 μg, were performed in a series of five 10-min infusions at 20-min intervals. All infusions were made from 12:30 to 15:00 and the pre-infusion period was from 10:00 to 12.30 h. The prolactin concentration in plasma samples, collected every 10 min, was determined by radioimmunoassay; prolactin mRNA expression in AP and MBH tissues was determined by real-time PCR. The obtained results showed that salsolinol infused at the higher dose significantly (p < 0.001) increased plasma prolactin concentration in lactating ewes, when compared with the concentration noted before the infusion and with that in lactating controls. In lactating ewes, the relative levels of prolactin mRNA expression in the AP and MBH were up to twofold and fivefold higher respectively than in non-lactating ewes (p < 0.05). In our experimental design, salsolinol did not significantly affect the ongoing process of prolactin gene expression in these tissues. We conclude that in ewes, salsolinol may be involved, at least, in the process of stimulation of prolactin release during lactation and that hypothalamic prolactin plays an important role in the central mechanisms of adaptation to lactation.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 90%

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The Possible Involvement of Salsolinol and Hypothalamic Prolactin in the Central Regulatory Processes in Ewes During Lactation

Górski¹,

Romanowicz²,

Herman

et al. 2009

Reproduction in Domestic Animals

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“…Furthermore, the mechanism(s) by which SAL releases PRL is different from the mechanism of action of TRH. In ruminants, the secretion of PRL is also under the inhibitory control of DA, and SAL does not antagonize the DA receptor's action [36,37]. These data support the assumption that this endogenous compound could have more general involvement in the regulation of pituitary PRL secretion and it is synthesized in different species also.…”

Section: Anterior Lobe (Al)supporting

confidence: 74%

Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release

Olah

Bodnár

Daniel

et al. 2011

Reprod Medicine & Biology

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(R)-Salsolinol (SAL), a dopamine (DA)-related tetrahydroisoquinoline, has been found in extracts of the neuro-intermediate lobes (NIL) of pituitary glands and in the median eminence of the hypothalamus obtained from intact male rats and from ovariectomized and lactating female rats. Moreover, analysis of SAL concentrations in NIL revealed parallel increases with plasma prolactin (PRL) in lactating rats exposed to a brief (10 min) suckling stimulus after 4-h separation. SAL is sufficiently potent in vivo to account for the massive discharge of PRL that occurs after physiological stimuli (i.e. suckling). At the same time, it was without effect on the secretion of other pituitary hormones. It has been also shown that another isoquinoline derivative, 1-methyldihydroisoquinoline (1MeDIQ), which is a structural analogue of SAL, can dose-dependently inhibit the in-vivo PRL-releasing effect of SAL. Moreover, 1MeDIQ can inhibit the elevation of plasma PRL induced by physiological stimuli, for example suckling, or in different stressful situations also. 1MeDIQ also has a psycho-stimulant action, which is fairly similar to the effect of amphetamine, i.e. it induces an increase in plasma catecholamine concentrations. It is clear from these data that this newly discovered endogenous compound could be involved in regulation of pituitary PRL secretion. It has also been observed that SAL is present in peripheral, sympathetically innervated organs, for example the atrium, spleen, liver, ovaries, vas deferens, and salivary gland. Furthermore, SAL treatment of rats results in dosedependent and time-dependent depletion of the DA content of the organs listed above without having any effect on the concentration of norepinephrine. More importantly, this effect of SAL can be completely prevented by amphetamine and by 1MeDIQ pretreatment. It is clear there is a mutual interaction between SAL, 1MeDIQ, and amphetamine or alcohol, not only on PRL release; their interaction with catecholamine ''synthesis/metabolism'' of sympathetic nerve terminals is also obvious.

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“…Interaction between TRH and dopamine in reptilian and amphibian pituitary have been reported and dopamine was demonstrated to inhibit TRH-stimulated release of prolactin, but not GH (Hall and Chadwick, 1984). Recently, this effect also was observed in cultured bovine anterior pituitary cells where dopamine inhibited the TRH-induced prolactin release in vitro (Hashizume et al, 2008).…”

Section: Discussionmentioning

confidence: 92%

Immunohistochemical localization of thyrotropin-releasing hormone in the brain of reptiles

López

Domı́nguez

González

2008

Journal of Chemical Neuroanatomy

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Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants

Cited by 19 publications

References 13 publications

The Possible Involvement of Salsolinol and Hypothalamic Prolactin in the Central Regulatory Processes in Ewes During Lactation

The Possible Involvement of Salsolinol and Hypothalamic Prolactin in the Central Regulatory Processes in Ewes During Lactation

Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release

Immunohistochemical localization of thyrotropin-releasing hormone in the brain of reptiles

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