Interaction between saquinavir and antimycotic drugs on C. albicans and C. neoformans strains

HIV aspartyl protease inhibitors as promising compounds againstCandida albicansAndré Luis Souza dos Santos

“…In this context, the combination of antimycotic agents and saquinavir both at sub-inhibitory concentrations was effectively demonstrated against strains of C. albicans isolated from HIVseropositive patients. The results described by Casolari et al [101] showed that the interaction between saquinavir and amphotericin B, 5-fluorocytosine, miconazole or fluconazole did not result in antagonism, and fluconazole acted in a more synergistic way. The advantage of the synergic effect of this combination was to attenuate the resistance and accompanying toxic phenomena, particularly and most importantly, in the event of long-term therapy as a result of the use of low dosages of both HIV PIs and anti-fungal drugs.…”

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury

“…In vivo experiments showed that CYP2J2 overexpression attenuates production of VCAM, E-selectin, IL-1 ␤ , and IL-6 while enhancing production of the anti-infl ammatory cytokine IL-10. In addition, CYP2J2 gene delivery via intravenous injection signifi cantly increased CYP2J2 expression in vivo in most organs, mainly aorta, heart, liver, and kidney ( 3,5,6,36,37 ), which may also explain some effects of heart protection. These results support the view that CYP2J2-derived EETs protect the heart via their antiinfl ammatory, antiapoptotic, and prosurvival effects.…”

In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species

“…Candida glabrata shows less susceptibility than other Candida species, and the development of resistance to fl uconazole among the clinical strains of C. albicans, C. parapsilosis and Candida tropicalis, hampers the treatment of these infections 13 . The activity against C. neoformans is of particular importance, as this yeast is the major cause of meningitis in AIDS patients and has been identifi ed as the fourth most common cause of life-threatening infection in AIDS patients 14 .…”