Interaction between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and job-related stress in insomnia: a cross-sectional study in Sichuan, China

Huang, Chan; Li, Ju; Lu, Lingeng; Ren, Xiaohui; Li, Yongru; Huang, Qian; Lan, Yajia; Wang, Yongwei

doi:10.1016/j.sleep.2014.01.023

Cited by 31 publications

(31 citation statements)

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“…Some of the serotonin candidate gene studies have also examined sleep in the context of psychopathology, finding significant results [53,54]. Recent studies have focused on G×E interactions, with Huang and colleagues [55] identifying significant main effects of 5-HTTLPR (each S allele conferring a >80% increase in risk) and a significant gene-environment interaction for job-related stress, such that for individuals with the SS genotype, those with high job-related stress had higher insomnia risk and those with low job-related stress had lower risk. Further, a recent review discussing predictors of insomnia included 5-HTTLPR as a contributor to poor sleep via stress reactivity mechanisms [56].…”

Section: Measured Gene Studies Of Insomniamentioning

confidence: 99%

Genetic Pathways to Insomnia

Lind

Gehrman

2016

Brain Sciences

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This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature with regard to each of the following common methodologies: twin and family studies, candidate gene studies, and genome-wide association studies (GWAS). Next, we summarize the most recent gene identification efforts (primarily GWAS results) and propose several potential mechanisms through which identified genes may contribute to the disorder. Finally, we discuss new genetic approaches and how these may prove useful for insomnia, proposing an agenda for future insomnia genetics research.

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Section: Measured Gene Studies Of Insomniamentioning

confidence: 99%

Genetic Pathways to Insomnia

Lind

Gehrman

2016

Brain Sciences

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“…Since we have not evaluated stress level, at present we are not able to confirm these results. The effect of 5-HTTLPR on sleep is sex dependent (Deuschle et al 2010, Hartmann et al 2014, Huang et al 2014, and this possible influence was excluded since the present study included only male Croatian army soldiers, while other studies included participants of both genders (Brummett et al 2007, Deuschle et al 2010. In students with a persistent short sleep pattern, an overrepresentation of the 5-HTTLPR SS genotype was detected in groups who reported shorter sleep and higher depressed mood scores (Carskadon et al 2012).…”

Section: Discussionmentioning

confidence: 77%

“…In agreement, in our study, non-depressed veterans with PTSD had significantly higher arousal symptoms (measured with the CAPS) compared to depressed veterans with PTSD, and these symptoms are presumably associated with higher stress levels. The relationship between the S allele and stress is not simple or straight forward, since the stress level influences insomnia, and in healthy Chinese workers with low, but not high level of job stress, the S allele was protective against insomnia (Huang et al 2014). In Chinese patients with PTSD, the S allele was related to elevated stress sensitivity, and 5-HTTLPR polymorphism influenced the relationship between stress and PTSD (Zhao et al 2017).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Serotonin Transporter Polymorphism, Platelet Serotonin Concentration and Insomnia in Non-Depressed Veterans With Posttraumatic Stress Disorder

Petrović

Erjavec²,

Perković³

et al. 2019

Psychiat Danub

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Background: The role of serotonin transporter and its functional gene polymorphism (5-HTTLPR, serotonin transporter linked polymorphic region) was investigated in sleep disturbances in various mental disorders, with conflicting findings. Here, the association of particular sleep disturbances with 5-HTTLPR genotypes and platelet serotonin (5-HT) concentration was determined simultaneously in veterans with posttraumatic stress disorder (PTSD), who were subdivided into those with or without comorbid depression. Subjects and methods: Croatian male, medication-free war veterans with PTSD (N=325), subdivided into those with or without comorbid depression, and subdivided further according to the various sleep disturbances, were evaluated using the Structured Clinical Interview, the Hamilton Rating Scale for Depression and the Clinician Administered PTSD Scale. Genotyping and platelet 5-HT concentration measurements were conducted using PCR and spectrofluorimetric methods, respectively. Results: Nominally higher frequency of the 5-HTTLPR LL genotype compared to S carriers (p=0.026; ² test) and significantly higher platelet 5-HT concentration (p=0.001; one-way ANOVA) were detected in non-depressed veterans with PTSD with early insomnia, compared to matched veterans without early insomnia. Conclusions: Over-representation of the LL genotype of the 5-HTTLPR and higher platelet 5-HT concentrations were detected in veterans with PTSD who did not develop comorbid depression but had severe early insomnia. These results suggest that 5-HTTLPR genotypes and platelet 5-HT concentration are associated with early insomnia in non-depressed veterans with PTSD. Limitations of the study were the cross-sectional nature of the study, biallelic assessment of the 5-HTTLPR, and a lack of use of the specific sleep measurement scales. These results should be replicated in larger samples, validated on different populations, using specific sleep measurement scales and triallelic 5-HTTLPR assessment.

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“…When new employees with potentially high susceptibility to occupational stress are identified at an early stage, it is easier to safeguard them from stressors and potentially stressful situations. Intrinsic, pre-employment factors are known to play an important role in stress in addition to extrinsic, work-related factors [ 8 – 10 ], suggesting occupational stress forms a distinct part of an individual’s stress burden. Accordingly, methods to evaluate individual susceptibility to occupational stress are clearly beneficial for formulating strategies to reduce employee turnover.…”

Section: Introductionmentioning

confidence: 99%

“…Specific predictions of susceptibility to occupational stress based on the data enable supervisors and managers to make more effective interventions. Any such predictive analysis needs to take account of differences in intrinsic, pre-employment factors, because occupational stress levels are known to differ among individuals with similar workplace conditions and workloads [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Potential predictors of susceptibility to occupational stress in Japanese novice nurses - a pilot study

Okita

Daitoku

Abe

et al. 2017

Environ Health Prev Med

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BackgroundOccupational stress is a known factor behind employee resignations; thus, early identification of individuals prone to such stress is important. Accordingly, in this pilot study we evaluated potential predictors of susceptibility to occupational stress in Japanese novice nurses.MethodsForty-two female novice nurses at Kagoshima University Hospital were recruited for the study population. Each underwent physical health and urinary examinations, and completed a lifestyle questionnaire at the time of job entry. Each also completed a Brief Job Stress Questionnaire (BJSQ), related to mental health status, at job entry and 5 months post-entry. Psychological stress, somatic symptoms, and combined BJSQ scores were determined for each time point.ResultsAll three stress condition scores had significantly decreased at 5 months post-entry, suggesting occupational stress. Systolic blood pressure (r = −0.324, p < 0.05) and urinary sodium (r = −0.313, p < 0.05) were significantly negatively correlated with combined BJSQ score at 5 months post-entry. Post-entry stress condition scores were significantly low in subjects reporting substantial 1-year body weight change (≤ ± 3 kg) and short times between dinner and bedtimes (≤2 h), though baseline stress condition scores were not. Urinary sodium concentration, 1-year body weight change, and pre-sleep evening meals were then targeted for multivariate analysis, and confirmed as independent explanatory variables for post-entry stress condition scores.ConclusionsOne-year body weight change, times between dinner and bedtimes, and urinary sodium concentration are promising potential predictors of susceptibility to occupational stress, and should be further investigated in future research.Trial registrationISRCTN ISRCTN17516023. Retrospectively registered 7 December 2016.

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Interaction between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and job-related stress in insomnia: a cross-sectional study in Sichuan, China

Cited by 31 publications

References 51 publications

Genetic Pathways to Insomnia

Genetic Pathways to Insomnia

The Association Between Serotonin Transporter Polymorphism, Platelet Serotonin Concentration and Insomnia in Non-Depressed Veterans With Posttraumatic Stress Disorder

Potential predictors of susceptibility to occupational stress in Japanese novice nurses - a pilot study

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