2019
DOI: 10.3389/fmicb.2019.01602
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Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening?

Abstract: With the aging of population, the number of indications for total joint replacement is continuously increasing. However, prosthesis loosening can happen and is related to two major mechanisms: (1) aseptic loosening due to prosthesis micromotion and/or corrosion and release of wear particles from the different components of the implanted material and (2) septic loosening due to chronic prosthetic joint infection (PJI). The “aseptic” character of prosthesis loosening has been challenged over the years, especiall… Show more

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Cited by 59 publications
(60 citation statements)
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“…Several studies demonstrate that debris-induced inflammation is more rapid when endotoxin or other proteins specific for bacteria were added to the prosthetic particles [10,17,45]. In addition, some evidence interrelates formation of biofilm on the implant surface with aseptic loosening via chronic inflammation [46]. Some studies suggest that antibiotics could attenuate PPOL and AL [47,48].…”
Section: Stimuli Of Periprosthetic Inflammationmentioning
confidence: 99%
“…Several studies demonstrate that debris-induced inflammation is more rapid when endotoxin or other proteins specific for bacteria were added to the prosthetic particles [10,17,45]. In addition, some evidence interrelates formation of biofilm on the implant surface with aseptic loosening via chronic inflammation [46]. Some studies suggest that antibiotics could attenuate PPOL and AL [47,48].…”
Section: Stimuli Of Periprosthetic Inflammationmentioning
confidence: 99%
“…In the case of infection, the presence of a prosthesis allows bacteria to adhere to it, develop a biofilm, and trigger an infection of the surrounding tissues. PJIs then lead to prosthesis loosening, amputation, or even the death of patients in the worst scenario, and represent high costs for society [ 26 , 29 ].…”
Section: Role Of Bacterial Biofilm In Prosthetic Joint Infectionsmentioning
confidence: 99%
“…Indeed, after surgery and during infection establishment, the immune system reacts not only to bacterial presence but also to the implant surface. This phenomenon is called foreign body response and leads to an inflammatory response involving the coagulation cascade, complement system, platelets, and immune cells, particularly neutrophils [ 4 , 29 , 40 ]. This inflammation, which occurs during surgery, can normally lead to physiological bone healing, but can also induce bone resorption accentuated during bone infections [ 41 ].…”
Section: Role Of Bacterial Biofilm In Prosthetic Joint Infectionsmentioning
confidence: 99%
“…Very few numbers of microbes are needed to infect the prosthesis. Such organisms firstly adhere to the prosthesis surface at the bone-implant interface (stem) and/or into the joint cavity [30]. In the latter, microbes frequently replicate themselves as planktonic bacteria, that are bacteria in "optimal" environmental conditions to growth (i.e., with a lot of nutriments), leading to recruitment of polymorphonuclear cells (PMNs), and clinical signs of septic arthritis ( Figure 2).…”
Section: The Pathophysiology Of Chronic Pjimentioning
confidence: 99%
“…Different types of biofilm exist, which form themselves at different speed, depending on the pathogen involved in the PJI. Bacteria can persist for decades in biofilm, and the interaction between the surface of the biofilm and the host cells could lead to prosthesis loosening, by persistent local activation of immune cells [30,31,33].…”
Section: The Pathophysiology Of Chronic Pjimentioning
confidence: 99%