Interaction between the Opioid Receptor OPRM1 Gene and Mother-Child Language Style Matching Prospectively Predicts Children’s Separation Anxiety Disorder Symptoms

Effects of Voluntary Running Wheel Exercise-Induced Extracellular Vesicles on Anxiety

“…Cysltr1 encodes cysteinyl leukotriene receptor 1; hippocampal knockdown prevented depressive-like behavior in mice (Yu et al, 2016 ). Oprm1 has been extensively studied in the context of single nucleotide polymorphisms (SNPs) (Mague and Blendy, 2010 ; Mura et al, 2013 ; Boparai et al, 2018 ). The gene encodes the μ opioid receptor.…”

Language Style Matching in Preschooler–Adult Dyads: Associations with Dyad Familiarity and Children’s Age

“…Studies of school-aged children and their parents suggest that higher LSM is associated with relationship quality—higher LSM is associated with greater attachment security (Borelli et al, 2016) and lower physiological stress reactivity in children (Borelli et al, 2016; Rasmussen et al, 2017). Furthermore, higher LSM predicts lower levels of separation anxiety symptoms 2 years later among children with a specific type of genetic polymorphism that may place children at risk for anxiety ( OPRM1 polymorphism A118G; Boparai et al, 2018). Thus, early evidence suggests that higher LSM is associated with relationship quality in children aged 8 years and older.…”

“…Specifically, young children have presumably already had extensive exposure to the language patterns of their primary caregivers on which to model their own language expression. Extant studies have tabulated LSM via samples of language taken from child and caregiver interactions with others (Boparai et al, 2018; Borelli et al, 2016; Rasmussen et al, 2017). However, narratives produced in the absence of the other member of the dyad may not be as strong a measure of matching as LSM derived from caregiver–child interactions.…”

Data_Sheet_1.xlsx

“…Cysltr1 encodes cysteinyl leukotriene receptor 1; hippocampal knockdown prevented depressive-like behavior in mice (Yu et al, 2016). Oprm1 has been extensively studied in the context of single nucleotide polymorphisms (SNPs) (Mague and Blendy, 2010;Mura et al, 2013;Boparai et al, 2018). The gene encodes the µ opioid receptor.…”

“…The gene encodes the µ opioid receptor. The G allele is a minor form associated with higher resting cortisol levels, blunting of the cortisol response to stress, and separation anxiety disorder (Mague and Blendy, 2010;Boparai et al, 2018). Also, the SNP affects the mRNA expression level, reducing expression by 50% compared to that of the A allele, inducing anxiety (Mura et al, 2013).…”