Interaction Between Topographic/Tomographic Parameters and Dry Eye Disease in Keratoconus Patients

Zemova, Elena; Eppig, Timo; Seitz, Berthold; Toropygin, S.G.; Arnold, Stefan; Langenbucher, Achim; Gräber, Stefan; Szentmáry, Nóra

doi:10.3109/02713683.2013.798667

Cited by 24 publications

(23 citation statements)

References 16 publications

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“…Moreover, we found TBUT values to be reduced in 73% of KC group patients and, although they were not statistically significant, these results coincide with those of Dogru et al 3 One possible explanation for this is the irregular corneal surface, which would does not permit formation of an adequate tear film. Zemova et al, 35 however, found a relationship between dry eye parameters and corneal irregularity. Additional study is necessary to clarify this point.…”

Section: Discussionmentioning

confidence: 96%

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

Carracedo

Recchioni

Alejandre-Alba

et al. 2014

Current Eye Research

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Section: Discussionmentioning

confidence: 96%

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

Carracedo

Recchioni

Alejandre-Alba

et al. 2014

Current Eye Research

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“…Present-day computerized Placido topography systems offer direct digital analysis of the image scene of the Placido mires projected onto the cornea and thus provide a valid and effective tool for detection of corneal irregularities. 1 In addition to axial and tangential curvature maps, 2 several other parameters (eg, corneal surface irregularity indices and Fourier and Zernike aberrations) 3 are available and might increase the sensitivity and specificity when evaluating refractive surgery patients. 4 Detailed topography data are customarily used in surgical planning, 5 especially in topography-guided treatments.…”

Section: Discussionmentioning

confidence: 99%

Digital pupillometry and centroid shift changes after cataract surgery

Kanellopoulos¹,

Asimellis²,

Georgiadou³

2015

Journal of Cataract and Refractive Surgery

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“…A correlation between ocular surface disease and KC stage has also been verified [25]. Although some of the KC screening indices are also sensitive to dry eye syndrome [26], no interaction between measures of dry eye syndrome and topographic/tomographic changes in KC patients could be shown [27].…”

Section: Introductionmentioning

confidence: 89%

“…A total OSDI score, vision-related subscore (derived from questions about vision and task performance), and discomfort-related subscore (derived from questions about ocular surface discomfort) were calculated for each participant as described by Mathews et al [29]. Score ranges were designated as normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), or severe (33-100) ocular surface disease.…”

Section: Methodsmentioning

confidence: 99%

Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients

Németh

Langenbucher

Eppig

et al. 2020

Journal of Ophthalmology

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Purpose. Keratoconus (KC) has been defined as a “noninflammatory” corneal disease, but recent studies have noted a potential inflammatory origin. We analysed the Ocular Surface Disease Index (OSDI) and ocular surface temperature (OST) in KC patients compared to controls. Patients and Methods. A total of 179 eyes in 90 patients with KC (topographic keratoconus classification 0-1 to 4, age 36.1 ± 12.5 years, 65.9% males) and 82 eyes in 41 controls (age 36.4 ± 12.8 years, 47.6% males) were examined. The participants completed the OSDI questionnaire and underwent corneal topography, tomography, and thermography. Additional outcome measures were vision- and discomfort-related OSDI subscores and mean OST at the corneal centre during 10 seconds of sustained eye opening after blinking. Results. The OSDI score (31.4 ± 22.4 vs. 17.5 ± 17.9) and vision- (17.7 ± 14.6 vs. 10.5 ± 13.2) and discomfort-related (14.3 ± 10.7 vs. 9.4 ± 10.5) OSDI subscores were significantly higher in KC patients than in controls (p<0.001). We found no significant difference in the central corneal OST (34.2 ± 0.6°C vs. 34.2 ± 0.7°C; p=0.41) between the two groups (p≥0.22). The OSDI score and subscores poorly to fairly correlated with the surface asymmetry index (SAI) and surface regularity index (SRI; r > 0.174, p<0.005), but did not correlate with the central corneal OST (r < 0.001). OST also did not correlate with the SAI, SRI, and central corneal thickness (r ≥ −0.086). Conclusion. KC patients had increased OSDI scores and vision- and discomfort-related OSDI subscores without an increase in the OST compared to a normal population. OSDI score/subscores weakly correlate with SAI and SRI but do not correlate with OST in KC patients or controls. Vision- and discomfort-related symptoms of KC have to be managed in parallel in ophthalmological practice, but the necessity of anti-inflammatory treatment cannot be verified through ocular thermography.

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Interaction Between Topographic/Tomographic Parameters and Dry Eye Disease in Keratoconus Patients

Abstract: There is no interaction between DES and topographic/tomographic changes in KC-patients.

Cited by 24 publications

References 16 publications

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

Digital pupillometry and centroid shift changes after cataract surgery

Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients

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