Interaction between warfarin and Chinese herbal medicines

Chua, Ying Xian; Ang, Xiang Ling; Zhong, Xi Ming; Khoo, Kei Siong

doi:10.11622/smedj.2015004

Cited by 41 publications

(29 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ginseng has been reported to interact with several drugs, yet its interaction with warfarin (blood-thinning drug) is the most documented (Yuan et al, 2004;Chua et al, 2015). A randomized, double-blind, placebo-controlled trial using 20 healthy patients concluded that a 2-week intake of American Ginseng (2 g/d; 1 g twice daily) significantly reduced peak international normalized ratio (INR) and peak plasma warfarin levels (Yuan et al, 2004).…”

Section: Safety Toxicity and Side Effects Of Ginsengmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

show abstract

Section: Safety Toxicity and Side Effects Of Ginsengmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, clove had been reported to exhibit anti-platelet activity and had potential interaction with warfarin [ 43 ]. Several traditional Chinese medicines also had interactions with warfarin [ 44 ]. In New Zealand, it was reported that over 60% of TM users did not realise that alternative medicines might interact with prescribed medications, and most of the users did not report to their health care professionals that they were using TM [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Use of traditional medicine for dental care by different ethnic groups in New Zealand

Guo

Low

et al. 2020

BMC Oral Health

View full text Add to dashboard Cite

Background There is an increasing public interest in the use of TM internationally, yet there is a paucity of research on the use of TM by the public in the dental setting. This study aimed to explore the views, use of and access to TM in dentistry among different ethnic groups residing in New Zealand. Methods Qualitative study and in-depth interviews were used. An individual semi-structured questionnaire was used to collect data. Interviews were recorded, transcribed, and analysed using an inductive approach to identify the main themes. Results Three main themes were extracted from interviews with 14 participants from diverse cultural backgrounds: [1] the perspectives of TM varied among different ethnic groups and included the involvement of spirituality, the environment, knowledge and usage of TM. [2] The TM that was used by different ethnic groups included plants, herbs, massage, and other forms of healing. Reasons for choosing traditional or western medicines generally included family tradition, access to TM, and finding a competent traditional healer. [3] The barriers in accessing TM included the paucity of traditional healers, difficulty accessing plants and cost, therefore most would look for a substitution or alternative treatment. Conclusion Even though the access to these TM in New Zealand was a challenge for the majority of the participants, they are still considered the first-line treatment for the majority. This study provided dental practitioners an insight into the different sort of TM used by the population. By understanding and acknowledging the use of TM, dental practitioners could create a supportive environment for patients to disclose their use of TM and allow them to educate patients on the use of TM.

show abstract

“…However, clove had been reported to exhibit anti-platelet activity and had potential interaction with warfarin (39). Several traditional Chinese medicines also had interactions with warfarin (40). In New Zealand, it was reported that over 60% of TM users did not realise that alternative medicines might interact with prescribed medications, and most of the users did not report to their health care professionals that they were using TM (41).…”

Section: Use Of Tm In Different Conditionsmentioning

confidence: 99%

Use of traditional medicine for dental care by different ethnic groups in New Zealand

Guo

Low

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: To explore the views, use of and access to traditional medicine (TM) among different ethnicities living in New Zealand. Methods: Qualitative study and in depth interviews were used. An individual semi-structured questionnaire was used to collect data. Interviews were recorded, transcribed, and analysed using an inductive approach to identify the main themes. Results: Three main themes were extracted from interviews with 14 participants from diverse cultural backgrounds: (1) the perspectives of TM varied among different ethnic groups, and included the involvement of spirituality, the environment, knowledge and usage of TM. (2) The TM that was used by different ethnic groups included plants, herbs, massage, and other forms of healing. Reasons for choosing traditional or western medicines generally included family tradition, access to TM, and finding a competent traditional healer. (3) The barriers in accessing TM included the paucity of traditional healers, difficulty accessing plants and cost, therefore most would look for substitution or alternative treatment. Conclusion: Even though the access to these TM in New Zealand was a challenge for the majority of the participants, they are still considered the first-line treatment for the majority. This study provided dental practitioners an insight into the different sort of TM used by the population. By understanding and acknowledging the use of TM, dental practitioners could create a supportive environment for patients to disclose their use of TM and allow them to educate patients on the use of TM.

show abstract

Interaction between warfarin and Chinese herbal medicines

Cited by 41 publications

References 87 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Use of traditional medicine for dental care by different ethnic groups in New Zealand

Use of traditional medicine for dental care by different ethnic groups in New Zealand

Contact Info

Product

Resources

About