Interaction effect of prenatal and postnatal exposure to ambient air pollution and temperature on childhood asthma

Lu, Chan; Zhang, Yinping; Li, Baizhan; Zhao, Zhuohui; Huang, Chen; Zhang, Xin; Qian, Hua; Wang, Juan; Liu, Wei; Sun, Yuexia; Norbäck, Dan; Deng, Qihong

doi:10.1016/j.envint.2022.107456

Cited by 67 publications

(16 citation statements)

References 80 publications

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“…The development of stroke is caused by a combination of risk factors, including abnormal metabolic factors, behavioral factors, and environmental factors ( 2 ). Global warming, heat waves, and cold waves, as well as increased air pollution, have become more frequent since the beginning of the twenty-first century, the effect of environmental factors on the incidence of stroke has become more and more significant ( 3 ). According to the findings of the Global Burden of Disease Study 2019 (GBD), the burden of disease due to non-optimal temperature and environmental particulate pollution accounts for up to 37% of disability-adjusted life years due to stroke ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Zhao

Zhang

Ying

et al. 2022

Front. Public Health

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BackgroundMost studies have focused on the relationship between ambient temperature and stroke mortality, but studies on the relationship between ambient temperature and stroke occurrence are still limited and inconsistent.ObjectiveThis study aimed to analyze the effect of ambient temperature and other environmental factors on emergency stroke visits in Beijing.MethodsOur study utilized stroke visit data from the Beijing Red Cross Emergency Medical Center during 2017–2018, and applied a generalized additive model (GAM) as well as a distributed lag non-linear model (DLNM), respectively, regarding the direct, lagged, and cumulative effects of ambient temperature alone and with correction for other environmental factors on stroke occurrence.ResultsWith a total of 26,984 emergency stroke patients in 2017–2018, both cold and hot effects were observed and weakened after correction for other environmental factors. Compared to the reference temperature, in the multi-factor model, extreme cold (−10°C) reached a maximum relative risk (RR) of 1.20 [95% Confidence Interval (CI): 1.09, 1.32] at lag 14 days, and extreme hot (30°C) had a maximum RR of 1.07 (95% CI: 1.04, 1.11) at lag 6 days. The cumulative effect of extreme cold reached a maximum of 2.02 (95% CI: 1.11, 3.67) at lag 0–14 days, whereas the cumulative effect of extreme hot temperature is greatest at lag 0–10 days, but no statistically significant effect was found. In addition, ischemic stroke patients, the elderly, and males were more susceptible to the effects of cold temperature.ConclusionsThere is a non-linear relationship between ambient temperature and stroke occurrence, with cold temperature having a greater and longer-lasting impact than hot temperature.

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Section: Introductionmentioning

confidence: 99%

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Zhao

Zhang

Ying

et al. 2022

Front. Public Health

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“…In this cross-sectional study, from June 2019 to June 2020, a questionnaire investigation was conducted in 7 major cities in China, including Wuhan, Changsha, Taiyuan, Nanjing, Shanghai, Chongqing, and Urumqi, as the second phase of the China, Children, Homes, Health (CCHH) study. 23 A standardized questionnaire was previously validated by a pilot study and was used in the CCHH study with written consent from the parents or legal guardians. 24 Ethics approval for the current study was acquired from the ethical committee of the School of Public Health, Fudan University.…”

Section: Methodsmentioning

confidence: 99%

Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China

Zhang

Wei

et al. 2022

JAMA Netw Open

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ImportanceExposure to particulate matter (PM) has been associated with childhood asthma and wheeze. However, the specific associations between asthma and PM with an aerodynamic equivalent diameter of 1 μm or less (ie, PM1), which is a contributor to PM2.5 and potentially more toxic than PM2.5, remain unclear.ObjectiveTo investigate the association of early-life (prenatal and first year) exposure to size-segregated PM, including PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10, with childhood asthma and wheeze.Design, Setting, and ParticipantsThis cross-sectional study was based on a questionnaire administered between June 2019 and June 2020 to caregivers of children aged 3 to 6 years in 7 Chinese cities (Wuhan, Changsha, Taiyuan, Nanjing, Shanghai, Chongqing, and Urumqi) as the second phase of the China, Children, Homes, Health study.ExposuresExposure to PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10 during the prenatal period and first year of life.Main Outcomes and MeasuresThe main outcomes were caregiver-reported childhood asthma and wheeze. A machine learning–based space-time model was applied to estimate early-life PM1, PM2.5, and PM10 exposure at 1 × 1-km resolution. Concentrations of PM1-2.5 and PM2.5-10 were calculated by subtracting PM1 from PM2.5 and PM2.5 from PM10, respectively. Multilevel (city and child) logistic regression models were applied to assess associations.ResultsOf 29 418 children whose caregivers completed the survey (15 320 boys [52.1%]; mean [SD] age, 4.9 [0.9] years), 2524 (8.6%) ever had wheeze and 1161 (3.9%) were diagnosed with asthma. Among all children, 18 514 (62.9%) were breastfed for more than 6 months and 787 (2.7%) had parental history of atopy. A total of 22 250 children (75.6%) had a mother with an educational level of university or above. Of the 25 422 children for whom information about cigarette smoking exposure was collected, 576 (2.3%) had a mother who was a current or former smoker during pregnancy and 7525 (29.7%) had passive household cigarette smoke exposure in early life. Early-life PM1, PM2.5, and PM10 exposure were significantly associated with increased risk of childhood asthma, with higher estimates per 10-μg/m3 increase in PM1 (OR, 1.55; 95% CI, 1.27-1.89) than in PM2.5 (OR, 1.14; 95% CI, 1.03-1.26) and PM10 (OR, 1.11; 95% CI, 1.02-1.20). No association was observed between asthma and PM1-2.5 exposure, suggesting that PM1 rather than PM1-2.5 contributed to the association between PM2.5 and childhood asthma. There were significant associations between childhood wheeze and early-life PM1 exposure (OR, 1.23; 95% CI, 1.07-1.41) and PM2.5 exposure (OR, 1.08; 95% CI, 1.01-1.16) per 10-μg/m3 increase in PM1 and PM2.5, respectively.Conclusions and RelevanceIn this cross-sectional study, higher estimates were observed for the association between PM with smaller particles, such as PM1, vs PM with larger particles and childhood asthma. The results suggest that the association between PM2.5 and childhood asthma was mainly attributable to PM1.

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“…A retrospective cohort study of 39 782 children in cities throughout China found that prenatal and postnatal heat exposure was associated with greater risk of childhood asthma. Extreme heat days (in which temperatures were ≥86°F) within a child's first year of life also increased their lifetime risk for asthma diagnosis [25]. With regards to temperature, individuals living in inner-city areas are again at a disadvantage.…”

Section: Outdoor Exposuresmentioning

confidence: 99%

“…Increased PM 2.5 exposure in childhood was associated with a greater risk for developing asthma [10,24]. High environmental NO 2 levels during prenatal period and in the first year of life were associated with greater asthma prevalence in preschool children [25].…”

Section: Outdoor Exposuresmentioning

confidence: 99%

Environment and the development of severe asthma in inner city population

Lee

Phipatanakul

Gaffin

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewHigher asthma prevalence and morbidity are seen in inner-city areas, disproportionately affecting low-income families living in substandard housing. Children within these families experience more frequent asthma exacerbations, acute care and emergency department visits, and hospitalizations, thus characterizing severe asthma. In this review, we assess recent published literature focused on indoor and outdoor exposures that contribute to the development and morbidity of asthma.Recent findingsMany urban environmental exposures contribute to asthma burden, including tobacco/e-cigarette smoke, pest allergens, molds, and possibly synthetic chemicals such as phthalates and bisphenol A, radon, and volatile organic compounds. Individuals living in inner-city areas also experience higher levels of air pollutants and ambient heat, further perpetuating asthma incidence and severity.SummaryThis article summarizes the latest advances and provides direction for future research on risk factors, interventions, and public policy to help alleviate the burden of asthma due to urban environment exposures.

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Interaction effect of prenatal and postnatal exposure to ambient air pollution and temperature on childhood asthma

Cited by 67 publications

References 80 publications

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China

Environment and the development of severe asthma in inner city population

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