Interaction of a synthetic peptide of the interferon α2 C‐terminal part with human blood leukocytes. II. Effect on protein tyrosine phosphorylation

Abstract

Tyrosinc phosphorylation in human blood lymphocytes was studied as a function of stimulation with concanavalin A (ConA) and treatmem of the cells with interferon a? (IFNa2) and/or an IFN-derived C-terminal synthetic pcptidc 2438 (amino acid residues 124-138). Both IFNa? and the prptide 2438 decreased the level of protein tyrosinc phosphorylation in the ConA-stimulated cells. In unstimulated cells, IFNaI) increased, and the peptide 2438 decreased the level of the tyrosinc phosphorylation. A possible correlation of these effects with stimulation of cell proliferation is discussed.