Interaction of acetylcholine and endothelin-1 in the modulation of pulmonary arterial pressure

Schmeck, Joachim; Konrad, Christoph; Schöffel, Susanne; Wendel-Wellner, Martina; Gluth, Heidi; Koch, Thea; Krafft, Peter

doi:10.1097/00003246-200012000-00022

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…In ALI and endotoxemia, ET-1 participates in several pathophysiological mechanisms apart from being a marker of vascular injury. Studies in animals and humans demonstrate that ET-1 causes pulmonary hypertension (10,11). Moreover, ET-1 increases pulmonary microvascular permeability, promoting lung edema (12,13).…”

mentioning

confidence: 99%

Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep

Kuklin

Киров

Evgenov

et al. 2004

Critical Care Medicine

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mentioning

confidence: 99%

Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep

Kuklin

Киров

Evgenov

et al. 2004

Critical Care Medicine

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“…Additionally, ACh’s cardioprotective actions have been associated with anti-inflammatory responses, revealing an unrecognized beneficial function of ACh in the cardiovascular system [ 5 ]. The effects of ACh on pulmonary circulation have been investigated by previous works [ 12 – 14 ]. α7 nicotinic acetylcholine receptor (α7 nAChR) plays an essential role in the execution of biological functions of acetylcholine.…”

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confidence: 99%

Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension

Yang,

Xu,

Shu

et al. 2024

BMC Pulm Med

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Background An increased acetylcholine (ACh) level in the right ventricle tissue of pulmonary hypertension (PH) was revealed, which indicated the important role of ACh in disease pathogenesis. However, the relationship between plasma ACh levels and disease conditions and patients’ prognosis has not been investigated. We aimed to explore the association between plasma ACh levels and the prognosis of patients with PH. We also discussed the feasibility of plasma ACh as a biomarker, which may contribute to the management of PH patients in the future. Methods Patients with confirmed PH in Fuwai Hospital from April 2019 to August 2020 were enrolled. The primary clinical outcome in this study was defined as a composite outcome, including death/lung transplantation, heart failure, and worsening of symptoms. Fasting plasma was collected to detect the ACh levels. The association between ACh levels and patients’ prognosis was explored. Results Finally, four hundred and eight patients with PH were enrolled and followed for a mean period of 2.5 years. Patients in the high ACh group had worse World Health Organization Functional Class (WHO-FC), lower 6-minute walk distance (6 MWD), and higher N-terminal pro-brain natriuretic peptide (NT-proBNP). Notably, echocardiographic and hemodynamic parameters in the high metabolite group also suggested a worse disease condition compared with the low ACh group. After adjusting for confounders, compared with low ACh patients, those with high metabolite levels still have worse prognoses characterized as elevated risk of mortality, heart failure, and symptoms worsening. Conclusion High circulating ACh levels were associated with severe PH conditions and poor prognosis, which might serve as a potential biomarker in PH.

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Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors

et al. 2021

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Interaction of acetylcholine and endothelin-1 in the modulation of pulmonary arterial pressure

Cited by 4 publications

References 27 publications

Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep

Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep

Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension

Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors

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