Interaction of acridine-calix[4]arene with DNA at the electrified liquid|liquid interface

Kivlehan, Francine; Lefoix, Myriam; Moynihan, Humphrey A.; Thompson, Damien; Ogurtsov, Vladimir I.; Herzog, Grégoire; Arrigan, Damien W. M.

doi:10.1016/j.electacta.2010.01.042

Cited by 27 publications

(22 citation statements)

References 30 publications

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“…Calixarene-facilitated IT was diminished by the complexation with DNA, providing the basis for DNA hybridization detection at ITIES. (152) Interactions of chitosan with picrate and eosin were recently characterized at ITIES, (153) and extraction of heparin molecules (molecular weights up to 20 kDa) facilitated by a carefully designed ionophore has been demonstrated, aiming into a development of amperometric heparin sensor. (154) These recent developments demonstrate that electrochemistry at ITIES has many potential applications for electroanalytical macromolecule sensing, and they offer a new approach for characterization of macromolecules.…”

Section: Macromolecule Sensingmentioning

confidence: 99%

Liquid/Liquid Interfaces, Electrochemistry atUpdate based on the original article by Frédéric Reymond, Hubert H. Girault,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Peljo

Girault

2012

Encyclopedia of Analytical Chemistry

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This article outlines the electrochemical methodology at the interface between two immiscible electrolyte solutions (ITIES). The fundamental concepts of the thermodynamics in biphasic systems are presented in order to show how ions are distributed between the two adjacent phases and hence, how a Galvani potential difference is established at an ITIES. Polarizable and nonpolarizable ITIES are then characterized, and it is further evidenced that the classical electroanalytical methodology at a solid electrode can be directly transposed to the ITIES, thereby allowing reversible charge‐transfer reactions to be easily monitored and interpreted. This theoretical approach is completed by a review of the analytical methods used at ITIES, namely cyclic voltammetry (CV), hydrodynamic methods, spectroscopic techniques, and micro‐ and nanointerfaces (which are the biphasic analogs of micro‐ and nanoelectrodes). The last part deals with the practical applications that electrochemistry at ITIES has attracted during the past decades in the development of amperometric and coulometric ion sensors and detectors, detection of macromolecules, extraction of metal ions by interfacial formation of a complex, and assessment of the properties and lipophilicity of ionizable drugs.

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Section: Macromolecule Sensingmentioning

confidence: 99%

Liquid/Liquid Interfaces, Electrochemistry atUpdate based on the original article by Frédéric Reymond, Hubert H. Girault,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Peljo

Girault

2012

Encyclopedia of Analytical Chemistry

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“…In recent years there have been many reports on the behaviour and detection of biomolecules at the ITIES. The detection of a range of biomolecules including amino acids [19], heparin [20,21], protamine [22,23], haemoglobin [24,25], lysozyme [26,27], insulin [28], dopamine [29][30][31], noradrenaline [31] and DNA [32] have been reported at the ITIES.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

O'Sullivan

Arrigan

2012

Electrochimica Acta

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Electrochemistry at liquid-liquid interfaces, or at interfaces between two immiscible electrolyte solutions (ITIES), provides a basis for the non-redox detection of biological molecules, based on iontransfer or adsorption processes. The electroactivity of myoglobin at an array of micron-sized liquidorganogel interfaces was investigated. The µITIES array was patterned with a silicon membrane consisting of an array of eight pores with radii of ~12.8 µm and a pore to pore separation of ~400 µm.Using cyclic voltammetry at the ITIES, the protein was shown to adsorb at the interface and facilitate the transfer of the organic phase electrolyte anions to the aqueous side of the interface. The electrochemical current response was linear with concentration in the range of 1 -6 µM, with corresponding surface coverage of 10 -50 pmol cm -2 . The reverse peak currents was found to be proportional to the voltammetric scan rate, indicating a desorption process. The detection of the protein was only possibly when the pH of the aqueous phase solution was below the pI of the protein. The steady-state simple ion transfer behaviour of tetraethylammonium cation was decreased on the forward sweep, providing a qualitative indication of the presence of adsorbed protein at the interface.Increasing the ionic strength of the aqueous phase resulted in enhanced peak currents, possibly due to aggregation of protein precipitates in the aqueous solution. UV/Vis absorbance spectroscopy was used 1 ISE Member.2 | P a g e to investigate the effects of various aqueous electrolyte solutions on the structure of the protein, and it was shown that at low pH the protein is at least partially denatured. These results provide the basis for label-free detection of myoglobin at the ITIES.

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“…O'Sullivan and Arrigan [107c] showed that w/PVC-DCH interfaces modified with AOT -showed an increase of the faradaic current (6-fold) and interfacial coverage (17-fold) for the detection of myoglobin which confirmed the ability of protein-surfactant complexes to enhance the electrochemical signal. On the other hand, cationic surfactants were reported to bind DNA [22,114] although little additional work has been carried out in this direction.…”

Section: Detection Of (Bio)macromoleculesmentioning

confidence: 99%

“…1) have been widely used for the characterisation of ions or ionisable compounds such as drugs, [19] amino acids, [20] proteins, [21] and DNA. [22] The use of electrochemical methods at the macro-ITIES has been shown to be powerful for exploration of electrocatalysis [23] and the basis of spectrochemical analysis, [24] as well as investigation of the behaviours of inorganic ions and biomolecules at liquid−liquid interfaces. [7,25] For example, Hartvig et al [21a] studied the interaction between lysozyme and two lipophilic ions at the oil−water interface using cyclic voltammetry and electrochemical impedance spectroscopy at such a macro-ITIES.…”

Section: Experimental Systemsmentioning

confidence: 99%

Electroanalytical Opportunities Derived from Ion Transfer at Interfaces between Immiscible Electrolyte Solutions

Arrigan¹,

Eulate²,

Liu³

2016

Aust. J. Chem.

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SummaryThis review presents an introduction to electrochemistry at interfaces between immiscible electrolyte solutions and surveys recent studies of this form of electrochemistry in electroanalytical strategies. Simple ion and facilitated ion transfers across interfaces varying from millimetre scale to nanometre scales are considered. Target detection strategies for a range of ions, inorganic, organic and biological, including macromolecules, are discussed.

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Interaction of acridine-calix[4]arene with DNA at the electrified liquid|liquid interface

Cited by 27 publications

References 30 publications

Liquid/Liquid Interfaces, Electrochemistry atUpdate based on the original article by Frédéric Reymond, Hubert H. Girault,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Liquid/Liquid Interfaces, Electrochemistry atUpdate based on the original article by Frédéric Reymond, Hubert H. Girault,Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

Electroanalytical Opportunities Derived from Ion Transfer at Interfaces between Immiscible Electrolyte Solutions

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