Interaction of amylin species with transition metals and membranes

His18 promotes reactive oxidative stress production in copper-ion mediated human islet amyloid polypeptide aggregation

“…The aggregation process of hIAPP has been proved to be modulated by many factors including pH value, metal ions, small chemical molecules, etc. [11][12][13][14][15] Copper ions are believed to be closely associated with T2D as clinical ndings show that the serum copper ions levels are higher in diabetic patients than in healthy people. 16,17 Recently, the particular role of copper ions in diseases associated with hIAPP aggregation has been studied extensively.…”

Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations

“…42,43 In addition, their ability to modulate the proteolytic activity of hIAPP-degrading enzymes has been extensively studied. 14,[44][45][46] It was reported that, Zn 2+ plays an important role in glycemic regulation, which is re-ected in their high concentrations in the interior of dense granule cores ranging from 10 to 20 mM, conrming their physiological importance. [47][48][49][50] The effect of concentrations of Zn 2+ on hIAPP aggregation has been studied in detail.…”

“…During the nal stages of aggregation (when the amylin brils are formed), ber formation is inhibited at low concentrations of Zn 2+ and accelerated at higher concentrations. 14,53 These ndings have been supplemented by a study on the effect of Al 3+ , Fe 3+ , Zn 2+ and Cu 2+ at near physiological concentrations (10 mM, i.e., in stoichiometric excess) on amylin at 0.4 and 2 mM (see Fig. 2).…”

“…11 Here, we review a number of biomolecules whose aggregation rates are dependent on their concentration and metal ion coordination properties. The biomolecules reviewed are the following: islet amyloid polypeptide (IAPP), which contributes to glycemic control and has implications for Type II diabetes, 13,14 Ab peptide and Tau protein, which are the main components of amyloid deposits found within the neuronal cells of patients with Alzheimer's disease (AD). 15,16 a-Synuclein, which is strongly associated with Parkinson's disease (PD).…”

Using NMR spectroscopy to investigate the role played by copper in prion diseases

“…The enzyme superoxide dismutase 1 (SOD1) is present in almost all eukaryotic cells and a few prokaryotic cells that contain both copper and zinc [40][41][42]215]. SOD1 catalyzes the dismutation of the superoxide radical to hydrogen peroxide and oxygen [43][44][45][46][47][48][49].…”