Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains

A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport

“…Furthermore, mutant Rab8 causes cell death of transgenic Xenopus rods (Moritz et al, 2001) and depletion of Rab8 from primary neurons inhibits neurite outgrowth (Huber et al, 1995). Second, Rab8 interacts with FIP-2 (optineurin) that also modulates cell morphogenesis and links Rab8 to the huntingtin protein (Li et al, 1998;Hattula and Peränen, 2000). Interestingly, mutations in optineurin cause primary open-angle glaucoma (Rezaie et al, 2002).…”

“…Rab8 is known to interact with the germinal center kinase, a protein involved in TNF-alpha signaling (Ren et al, 1996). There is also a connection of the Rab8-interacting protein optineurin (FIP-2) to TNF-alpha-mediated signals (Li et al, 1998;Schwamborn et al, 2000). TNF-alpha is a major mediator of inflammatory responses, and it induces changes in several cellular processes, such as cell migration, differenti- Figure 7.…”

Gene delivery from the E3 region of replicating human adenovirus: evaluation of the E3B region

“…10 RID also clears other receptors from the cell surface including EGF-R. [10][11][12] The third gene in E3B encodes a protein known as 14.7 K that also protects the cell from TNF and has been shown to bind to a variety of proteins including FLICE. [13][14][15] We have previously demonstrated that therapeutic transgenes can be delivered predictably from the E3…”

Toward an integrative view of Optineurin functions

“…1 FIP-2 was subsequently renamed Optineurin ("optic neuropathy inducing") following the association of Optn gene mutations with primary open-angle glaucoma (POAG). Optn is also known by several other names, including NRP (NEMO-related protein), HIP7 (Huntingtin-interacting protein 7), HYPL (Huntingtin yeast partner L) and TFIIIA-INTP (transcription factor IIIAinteracting protein).…”