2015
DOI: 10.1007/s10895-015-1601-6
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Interaction of Anthracycline 3′-azido-epirubicin with Calf Thymus DNA via Spectral and Molecular Modeling Techniques

Abstract: Anthracycline antibiotics are extensively applied to clinical antitumor therapy. The binding mode and mechanism of a new anthracycline 3'-azido-epirubicin (AEPI) with calf thymus deoxyribonucleic acid (ctDNA) were investigated employing multiple spectroscopy techniques in Tris-HCl buffer solution (pH 7.4). Effect of pH on the interaction was provided to determine the proper environment for whole research. Iodide quenching studies and fluorescence polarization measurement indicated that ctDNA quenched the fluor… Show more

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Cited by 3 publications
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“…The constant k q was also used to characterize the quenching mechanism. When k q is less than 2.0 × 10 10 M −1 s −1 , the quenching is preferentially dynamic, whereas static quenching is expected for higher k q values ( Cui et al, 2015 ). The k q values range from 0.75 to 2.80 × 10 12 M −1 s −1 , being higher than the limiting diffusional constant.…”
Section: Resultsmentioning
confidence: 99%
“…The constant k q was also used to characterize the quenching mechanism. When k q is less than 2.0 × 10 10 M −1 s −1 , the quenching is preferentially dynamic, whereas static quenching is expected for higher k q values ( Cui et al, 2015 ). The k q values range from 0.75 to 2.80 × 10 12 M −1 s −1 , being higher than the limiting diffusional constant.…”
Section: Resultsmentioning
confidence: 99%