Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods

Electrochemical investigations of unexplored anthraquinones and their DNA binding

“…The cathodic peak potential was shifted (80.3 mV) anodically while the anodic peak potential underwent a drift of 30.2 mV in the cathodic direction accompanied with the decrease in peak currents. In general the positive shift in peak potential is suggested for intercalation of the drug into the stacked base pair pockets of DNA [22], while negative shift is related to electrostatic interaction of the drug with the anionic phosphate backbone of DNA [23]. So, the obvious positive peak potential shift in the cathodic peak of CM can be attributed to the intercalation of CM into the base pair pockets of DNA.…”

Lactofen – Electrochemical Sensing and Interaction with dsDNA

“…Electrochemical techniques offer inexpensive methods for environmental analysis [1][2][3]. There are several methods for the investigation of interaction between DNA and organic compounds [4][5][6][7]. Modern electrochemical techniques represent a very useful tool for this purpose [8], and mercury [9], amalgam [2], and carbon [10] electrodes are most often applied in such experiments.…”

Preparation of ds-DNA functionalized magnetic nanobaits for screening of bioactive compounds from medicinal plant

“…Small molecules interact with DNA in many ways, including intercalation [1,2], groove binding [3,4] and electrostatic binding [5,6]. A variety of techniques have been used to study the interactions between DNA and its binders, such as DNA-footprinting [7,8], nuclear magnetic resonance (NMR) [9,10], mass spectrometry (MS) [11,12], molecular modeling techniques [13], electrochemical measurement [14][15][16][17] and some spectroscopic methods [18][19][20][21]. It has been reported that the anti-cancer drug irinotecan can attach to DNA through electrostatic binding [22]; distamycin can form a monomer or dimer and bind in the minor groove of double helix DNA [23]; and berberine can bind to double helix DNA at AT-rich sequences preferentially [24].…”