Interaction of APOE genotype and testosterone on episodic memory in middle-aged men

Panizzon, Matthew S.; Hauger, Richard L.; Xian, Hong; Vuoksimaa, Eero; Spoon, Kelly M.; Mendoza, Sally P.; Jacobson, Kristen C.; Vasilopoulos, Terrie; Rana, Brinda K.; McKenzie, Ruth; McCaffery, Jeanne M.; Lyons, Michael J.; Kremen, William S.; Franz, Carol E.

doi:10.1016/j.neurobiolaging.2013.12.025

Cited by 28 publications

(23 citation statements)

References 101 publications

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“…These results highlight the need for additional studies of the E4 gene by environmental interactions, especially in various nonindustrial environments, and for focusing on the neurobiology of middle age in addition to older age and the need to take a life‐course perspective (55, 56). Other studies have found evidence of protective interactions between E4 alleles, cognitive function, and a host of other phenotypic characteristics, including testosterone (57), estrogen (58), and physical activity (59). Considered together, the evidence suggests that the impacts of the E4 allele are not always deleterious and may be adaptive and beneficial in some populations with a high infectious burden.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden

et al. 2016

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The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer disease (AD). The E4 allele is especially prevalent in some tropical regions with a high parasite burden. Equatorial populations also face a potential dual burden of high E4 prevalence combined with parasitic infections that can also reduce cognitive performance. We examined the interactions of E4, parasite burden, and cognitive performance in a traditional, nonindustrialized population of Amazonian forager-horticulturalists ( 372) to test whether E4 protects against cognitive decline in environments with a heavy pathogen burden. Contrary to observations in industrial populations, older adult E4 carriers with high parasite burdens either maintained or showed slight improvements in cognitive performance, whereas non-E4 carriers with a high parasite burden showed reduced cognitive performance. Being an E4 carrier is the strongest risk factor to date of AD and cognitive decline in industrial populations; it is associated with greater cognitive performance in individuals facing a high parasite and pathogen load, suggesting advantages to the E4 allele under certain environmental conditions. The current mismatch between postindustrial hygienic lifestyles and active parasite-rich environs may be critical for understanding genetic risk for cognitive aging.-Trumble, B. C., Stieglitz, J., Blackwell, A. D., Allayee, H., Beheim, B., Finch, C. E., Gurven, M., Kaplan, H. Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden.

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Section: Discussionmentioning

confidence: 99%

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden

et al. 2016

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“…There was no evidence for the APOE allele to affect thyroid status in males. On the other hand, in middle-aged men being ε4 allele carriers, the free testosterone level was positively associated with verbal episodic memory performance (story recall), whereas no association was observed in ε4 allele noncarriers [43]. Also individuals with both low free testosterone levels and at least one copy of the ε4 allele had smaller hippocampal volumes than men who had none or only one of these risk factors [44].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function, <b><i>APOE</i></b> Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Bojar¹,

Stasiak²,

Cyniak-Magierska³

et al. 2016

Dement Geriatr Cogn Disord

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Background: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). Methods: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory. Results and Conclusion: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.

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“…For example, a smaller hippocampus is evidenced in middle-aged men with lower serum testosterone levels possessing an APOE4 allele (Panizzon et al, 2010). Further, better verbal memory in middleaged men with APOE4 was found in those with higher levels of testosterone (Panizzon et al, 2014). Increased amyloid burden was associated with decreased testosterone levels in men with mild cognitive impairment (MCI) carrying at least one APOE4 allele (Verdile et al, 2014).…”

Section: Androgens and Neurogenesis: Potential Implications For Cognimentioning

confidence: 99%

Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms

Mahmoud

Wainwright

Galea

2016

Frontiers in Neuroendocrinology

169

110

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Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous factors. Here, we review the role of sex hormones in the regulation of adult hippocampal neurogenesis in males and females. The review is framed around the potential functional implications of sex hormone regulation of adult hippocampal neurogenesis, with a focus on cognitive function and mood regulation, which may be related to sex differences in incidence and severity of dementia and depression. We present findings from preclinical studies of endogenous fluctuations in sex hormones relating to reproductive function and ageing, and from studies of exogenous hormone manipulations. In addition, we discuss the modulating roles of sex, age, and reproductive history on the relationship between sex hormones and neurogenesis. Because sex hormones have diverse targets in the central nervous system, we overview potential mechanisms through which sex hormones may influence hippocampal neurogenesis. Lastly, we advocate for a more systematic consideration of sex and sex hormones in studying the functional implications of adult hippocampal neurogenesis.

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Interaction of APOE genotype and testosterone on episodic memory in middle-aged men

Cited by 28 publications

References 101 publications

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager‐horticulturalists with a high parasite burden

Cognitive Function, <b><i>APOE</i></b> Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms

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