Breathing is essential to life; therefore, alterations in breathing are threatening to one's well-being. This chapter focuses on respiratory diseases, their associations with couple factors, and the role of partner-involved treatments. The chapter begins by reviewing basic information on the etiology, mechanisms, epidemiology, and prognosis for the most common respiratory diseases: asthma, upper respiratory infections (URIs), chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), lung cancer, cystic fibrosis (CF), and tuberculosis (TB). It then reviews the association hetween respiratory illnesses and intimate relationship satisfaction and goes on to discuss assessment and treatmenr and how they relate to couples.