Interaction of Biomechanics with Extracellular Matrix Components in Abdominal Aortic Aneurysm Wall

Tanios, F.; Gee, Michael W.; Pelisek, Jaroslav; Kehl, S.; Biehler, Jonas; Grabher-Meier, V.; Wall, Wolfgang A.; Eckstein, Hans‐Henning; Reeps, Christian

doi:10.1016/j.ejvs.2015.03.021

Cited by 26 publications

(20 citation statements)

References 38 publications

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“…24 Reduced elastin is associated with increasing AAA diameter, and the increased collagen content is correlated with high local wall stresses. 169 Because of this loss of load bearing fibrillar proteins, specifically elastin, the aortic wall undergoes progressive remodeling leading to increased level of collagen turnover along with high collagen content of the affected tissue. 99 This altered ECM is unable to withstand the resulting high wall stress and altered blood flow patterns.…”

Section: Pgg As a Potential Therapeutic Option For Aaa Patientsmentioning

confidence: 99%

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

et al. 2018

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Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.

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Section: Pgg As a Potential Therapeutic Option For Aaa Patientsmentioning

confidence: 99%

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

et al. 2018

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“…Our in vitro study has several limitations and does not completely replicate the periadventitial [17,18,19] or intraluminal routes [22] of PGG administration, so a direct comparison with known elastase AAA models is not possible. Further, the simulated aneurysmal matrix (group E) is not an exact replica of the complex ECM degradation observed in human AAA [7,34,61]. The shear components of deformation were considered negligible during the biaxial tensile experiments, similar to a previous study of the human abdominal aorta by Vande Geest et al [37] Nevertheless, shear calculations from planar biaxial testing of soft tissues are a complex and controversial topic [38,62,63,64].…”

Section: Discussionmentioning

confidence: 99%

“…Increased elastase activity leads to disorganized and tortuous elastin fibers [5], which represents a compromised organization of load bearing proteins, resulting in reduced aortic elasticity [4,6], and further weakening of the aortic wall. With the deficiency in elastin, collagen dominates the ECM [7]. Disease progression is characterized by an increase in matrixmetalloproteinase (MMP) activity, which subsequently yields elevated wall stress and concomitantly higher wall stress to strength ratios [4,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…With the deficiency in elastin, collagen dominates the ECM [7]. Disease progression is characterized by an increase in matrixmetalloproteinase (MMP) activity, which subsequently yields elevated wall stress and concomitantly higher wall stress to strength ratios [4,6,7,8]. In addition, most aneurysms exhibit an intraluminal thrombus (ILT), which is also a source of proteolytic activity [9], increased wall weakening [10], and a preferential site for rupture [11].…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical Restoration Potential of Pentagalloyl Glucose after Arterial Extracellular Matrix Degeneration

et al. 2019

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The objective of this study was to quantify pentagalloyl glucose (PGG) mediated biomechanical restoration of degenerated extracellular matrix (ECM). Planar biaxial tensile testing was performed for native (N), enzyme-treated (collagenase and elastase) (E), and PGG (P) treated porcine abdominal aorta specimens (n = 6 per group). An Ogden material model was fitted to the stress–strain data and finite element computational analyses of simulated native aorta and aneurysmal abdominal aorta were performed. The maximum tensile stress of the N group was higher than that in both E and P groups for both circumferential (43.78 ± 14.18 kPa vs. 10.03 ± 2.68 kPa vs. 13.85 ± 3.02 kPa; p = 0.0226) and longitudinal directions (33.89 ± 8.98 kPa vs. 9.04 ± 2.68 kPa vs. 14.69 ± 5.88 kPa; p = 0.0441). Tensile moduli in the circumferential direction was found to be in descending order as N > P > E (195.6 ± 58.72 kPa > 81.8 ± 22.76 kPa > 46.51 ± 15.04 kPa; p = 0.0314), whereas no significant differences were found in the longitudinal direction (p = 0.1607). PGG binds to the hydrophobic core of arterial tissues and the crosslinking of ECM fibers is one of the possible explanations for the recovery of biomechanical properties observed in this study. PGG is a beneficial polyphenol that can be potentially translated to clinical practice for preventing rupture of the aneurysmal arterial wall.

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“…Dp-ucMGP is associated with progression of CKD, that being later stage CKD patients have higher circulating dp-ucMGP levels (94)(95)(96)(97). Vitamin K2 supplementation has been shown to improve renal artery function and prevent further development of renal artery calcification (62,98). This has an overall benefit to renal function.…”

Section: Vitamin K2: Chronic Kidney Diseasementioning

confidence: 99%

Role of vascular remodeling in atherosclerosis and aortic aneurysm

Petsophonsakul

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Interaction of Biomechanics with Extracellular Matrix Components in Abdominal Aortic Aneurysm Wall

Cited by 26 publications

References 38 publications

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

Biomechanical Restoration Potential of Pentagalloyl Glucose after Arterial Extracellular Matrix Degeneration

Role of vascular remodeling in atherosclerosis and aortic aneurysm

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